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The map label for this gene is guaA

Identifier: 197104883

GI number: 197104883

Start: 1605928

End: 1607490

Strand: Direct

Name: guaA

Synonym: PHZ_c1417

Alternate gene names: 197104883

Gene position: 1605928-1607490 (Clockwise)

Preceding gene: 197104882

Following gene: 197104884

Centisome position: 40.19

GC content: 68.59

Gene sequence:

>1563_bases
ATGACCGACACCGCCGACCACGAGCACGTCCTGATCGTCGACTTCGGGAGTCAGGTGACCCAGCTCATCGCCCGGCGCCT
GCGGGAGAGCGGCGTCTATTGCGAGATCCACCCCTACGACAAGGTGGACGCGGTCCTCGACAGCTTCCGGCCCAAGGCGG
TAATCCTCTCGGGCGGGCCGGCCAGCGTGCACGAGGCCGAGAGTCCGGCGGCCTCGAAGCGCCTGTTCGAGCTGGACGTG
CCGGTCCTGGGCATCTGTTACGGCGAACAGACGATGTGCGACGTGCTCGGCGGCAAGGTCGAGCCGGGGACTACTCGCGA
GTTCGGCCGGGCCGAGATCGAGATCGTGCGCGAAAGCCCGCTGCTGGACGGCCTGGGCGGCGCCGGCCACTTCGAACCGG
TATGGATGAGCCACGGCGACAAGGTCACGGCCCTGCCCATGGGTTTCGAGACGGTGGCCGTCTCGGAGGGCAGCCCCTTC
GCCGTCATCGCCGACGAAGGCCGACGGTTCTACGGCATCCAGTTCCACCCCGAGGTCGCTCACACCCCGCGCGGGGCGCT
GATCCTGCGCAACTTCACCCACAAGATCGCGGGCCTGAAGGGCGACTGGACCATGAAGGCCTTCCGCGAGGAGGCCATCG
CCCGCATCCGCGACCAGGTCGGCGACGGCCGGATCATCTGCGGCCTCTCCGGCGGCGTGGACTCGTCCGTGGCCGCCGTG
CTGATCCACGAGGCGATCGGCGACCAGCTCACCTGCGTCTTCGTCGATCACGGCCTGCTGCGCCTGAACGAGGCAGAGCA
GGTCGTGACCATGTTCCGGGATCACTACAACATCCCGCTGGTCCACGTTGATGCGGCTGAGGAATTCCTCGGCGCGCTGG
CGGGCGTCACCGATCCGGAGACCAAGCGCAAGACCATCGGTCGGCTGTTCGTCGAGGTGTTCGACCGCGAGGCGGCGAAG
ATCGAGGGCGCGGCGTTCCTGGCCCAGGGCACGCTCTATCCGGACGTGATCGAGAGCGTCTCGGCCCGCGGCGGCCCCTC
GGCGGTGATCAAGAGCCACCACAACGTCGGCGGGCTGCCGGACTACATGAAGCTCAAGCTGGTCGAGCCCCTGCGCGAGC
TGTTCAAGGACGAGGTTCGCGCGCTCGGCGTGGAGCTGGGCCTGCCGCCGCAGTTCGTCGGCCGCCACCCGTTCCCCGGC
CCGGGCCTCGCCATCCGCATCCCCGGCGAAGTCACGCCCGAGCGGGTCGCTATCCTGCAGAAAGCCGACGCCATCTACCT
GGACGAAATCCGCAAGGCCGGCCTCTACGACTCCATCTGGCAGGCCTTCGCCGTCCTGCTGCCGGTCCGCACCGTCGGCG
TGATGGGCGATGCGCGCACCTACGACGAGGTCTGCGCCCTGCGCGCCGTGACCTCGACCGACGGCATGACCGCCGACTTC
TTCGAGTTCCCCTGGGAGGTCCTCAGCCGGGCCGCCACGCGGATCATCAACGAGGTGCGCGGCATCAACCGCGTCGTCTA
CGACGTGACGTCGAAGCCGCCCGGCACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
CTACCTCACGCCTGCCGGCGATCTGCGCCTTTCTCCCCGCACCTCCGGCACCGACGGCTTTTTCGTCGCGGTGCTGGAGA
AAGCCCGCTAACGGAGCCCC

Downstream 100 bases:

>100_bases
TCCGATAGCCGTCCGAGGCTATCGCAGAAGCCCGGAAAGCACGCGTAAGTCATTGAACAAAAACGTGATTGCCGCCGCCA
CCTATCGGCATCTATCGGGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTDTADHEHVLIVDFGSQVTQLIARRLRESGVYCEIHPYDKVDAVLDSFRPKAVILSGGPASVHEAESPAASKRLFELDV
PVLGICYGEQTMCDVLGGKVEPGTTREFGRAEIEIVRESPLLDGLGGAGHFEPVWMSHGDKVTALPMGFETVAVSEGSPF
AVIADEGRRFYGIQFHPEVAHTPRGALILRNFTHKIAGLKGDWTMKAFREEAIARIRDQVGDGRIICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDHGLLRLNEAEQVVTMFRDHYNIPLVHVDAAEEFLGALAGVTDPETKRKTIGRLFVEVFDREAAK
IEGAAFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLPPQFVGRHPFPG
PGLAIRIPGEVTPERVAILQKADAIYLDEIRKAGLYDSIWQAFAVLLPVRTVGVMGDARTYDEVCALRAVTSTDGMTADF
FEFPWEVLSRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MTDTADHEHVLIVDFGSQVTQLIARRLRESGVYCEIHPYDKVDAVLDSFRPKAVILSGGPASVHEAESPAASKRLFELDV
PVLGICYGEQTMCDVLGGKVEPGTTREFGRAEIEIVRESPLLDGLGGAGHFEPVWMSHGDKVTALPMGFETVAVSEGSPF
AVIADEGRRFYGIQFHPEVAHTPRGALILRNFTHKIAGLKGDWTMKAFREEAIARIRDQVGDGRIICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDHGLLRLNEAEQVVTMFRDHYNIPLVHVDAAEEFLGALAGVTDPETKRKTIGRLFVEVFDREAAK
IEGAAFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLPPQFVGRHPFPG
PGLAIRIPGEVTPERVAILQKADAIYLDEIRKAGLYDSIWQAFAVLLPVRTVGVMGDARTYDEVCALRAVTSTDGMTADF
FEFPWEVLSRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_519_residues
TDTADHEHVLIVDFGSQVTQLIARRLRESGVYCEIHPYDKVDAVLDSFRPKAVILSGGPASVHEAESPAASKRLFELDVP
VLGICYGEQTMCDVLGGKVEPGTTREFGRAEIEIVRESPLLDGLGGAGHFEPVWMSHGDKVTALPMGFETVAVSEGSPFA
VIADEGRRFYGIQFHPEVAHTPRGALILRNFTHKIAGLKGDWTMKAFREEAIARIRDQVGDGRIICGLSGGVDSSVAAVL
IHEAIGDQLTCVFVDHGLLRLNEAEQVVTMFRDHYNIPLVHVDAAEEFLGALAGVTDPETKRKTIGRLFVEVFDREAAKI
EGAAFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLPPQFVGRHPFPGP
GLAIRIPGEVTPERVAILQKADAIYLDEIRKAGLYDSIWQAFAVLLPVRTVGVMGDARTYDEVCALRAVTSTDGMTADFF
EFPWEVLSRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=557, Percent_Identity=35.9066427289048, Blast_Score=291, Evalue=7e-79,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=58.0952380952381, Blast_Score=618, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=35.6140350877193, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=35.6140350877193, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=35.6140350877193, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=53.8610038610039, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=35.8181818181818, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_PHEZH (B4R9R7)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130260.1
- ProteinModelPortal:   B4R9R7
- GeneID:   6790924
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1417
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56795; Mature: 56663

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTADHEHVLIVDFGSQVTQLIARRLRESGVYCEIHPYDKVDAVLDSFRPKAVILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEECCC
ASVHEAESPAASKRLFELDVPVLGICYGEQTMCDVLGGKVEPGTTREFGRAEIEIVRESP
CCCCCCCCCHHHCEEEEECCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
LLDGLGGAGHFEPVWMSHGDKVTALPMGFETVAVSEGSPFAVIADEGRRFYGIQFHPEVA
CCCCCCCCCCCCCCEECCCCEEEEEECCCEEEEECCCCCEEEEECCCCEEEEEEECCCCC
HTPRGALILRNFTHKIAGLKGDWTMKAFREEAIARIRDQVGDGRIICGLSGGVDSSVAAV
CCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLTCVFVDHGLLRLNEAEQVVTMFRDHYNIPLVHVDAAEEFLGALAGVTDPE
HHHHHHCCCEEEEEECCCCEEECHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCH
TKRKTIGRLFVEVFDREAAKIEGAAFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DYMKLKLVEPLRELFKDEVRALGVELGLPPQFVGRHPFPGPGLAIRIPGEVTPERVAILQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
KADAIYLDEIRKAGLYDSIWQAFAVLLPVRTVGVMGDARTYDEVCALRAVTSTDGMTADF
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHH
FEFPWEVLSRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TDTADHEHVLIVDFGSQVTQLIARRLRESGVYCEIHPYDKVDAVLDSFRPKAVILSGGP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEECCC
ASVHEAESPAASKRLFELDVPVLGICYGEQTMCDVLGGKVEPGTTREFGRAEIEIVRESP
CCCCCCCCCHHHCEEEEECCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
LLDGLGGAGHFEPVWMSHGDKVTALPMGFETVAVSEGSPFAVIADEGRRFYGIQFHPEVA
CCCCCCCCCCCCCCEECCCCEEEEEECCCEEEEECCCCCEEEEECCCCEEEEEEECCCCC
HTPRGALILRNFTHKIAGLKGDWTMKAFREEAIARIRDQVGDGRIICGLSGGVDSSVAAV
CCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLTCVFVDHGLLRLNEAEQVVTMFRDHYNIPLVHVDAAEEFLGALAGVTDPE
HHHHHHCCCEEEEEECCCCEEECHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCH
TKRKTIGRLFVEVFDREAAKIEGAAFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DYMKLKLVEPLRELFKDEVRALGVELGLPPQFVGRHPFPGPGLAIRIPGEVTPERVAILQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
KADAIYLDEIRKAGLYDSIWQAFAVLLPVRTVGVMGDARTYDEVCALRAVTSTDGMTADF
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEECCCCCCHHH
FEFPWEVLSRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA