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The map label for this gene is pccB [H]

Identifier: 197104740

GI number: 197104740

Start: 1450195

End: 1451733

Strand: Direct

Name: pccB [H]

Synonym: PHZ_c1274

Alternate gene names: 197104740

Gene position: 1450195-1451733 (Clockwise)

Preceding gene: 197104734

Following gene: 197104741

Centisome position: 36.29

GC content: 67.25

Gene sequence:

>1539_bases
TTGTTCGTGAAGCACATCCTGGAAGAGCTCGAGAAGCGCCGCGCCGAAGCCCGGCTGGGCGGGGGCGAGAAGCGGATCGC
CGCGCAGCACGCCAAGGGCAAGCTGACCGCGCGCGAGCGGATCGACCTCCTGCTCGACGAGGGCTCGTTCGAGGAGTTCG
ACATGTTCGTCGAGCACCGCGTCACCGAGTTCGGGATGGAGAAGCAGCGGATCCCCGGCGACGGCGTCGTCACCGGCTGG
GGGACCATCAACGGCCGCGTCGTCTACGTCTTCTCCAAGGACTTCACGGTATTCGGCGGCTCGCTGTCGAGCGCCCACGC
CGAGAAGATCCTCAAGGTCCAGCGCCAGGCGCTTAAGGTCGGCGCGCCGATCATCGGCCTGTTCGACGCCGGCGGCGCCC
GCATCCAGGAGGGCGTGGCGGCCCTGGGCGGCTACGCCGACATCTTCCTCGAGAACACCCTGGCCTCGGGCGTCATCCCG
CAGATCAGCGTGATCATGGGCCCCTGCGCCGGCGGCGACGTCTATTCGCCGGCGATCACCGACTTCATCTTCATGGTGAA
GGACACCTCGTACATGTACGTGACCGGTCCCGACGTGGTGAAGACGGTCACCCACGAGGAGGTCAGCCACGAGGAGCTGG
GCGGCTACCGCGTCCACGCCCTGAAGTCCGGCGTCGCCGACGGCGCGTTCGAGAACGACCTCGAGGCGCTGACCCAGGTG
CGCCGCCTGGTGGACTTCCTGCCGCTGTCCAACCGCGAGAAGCCGCCGGTCCGCACGAGCTTCGACGATCCCGAGCGCGA
GGAGGCCTCGCTCGACACCCTCGTGCCGGCCAATCCGAACAAGCCCTACGACATGAAGGAGCTGATCCTGAAGGTCGTGG
ACGAGGCCGACTTCTTCGAGATCAGCCCGGACTTCGCCAAGAACATCGTCGTCGGCTTCGCGCGCATGGACGGCCAGACG
GTGGGGATCGTGGCCAACCAGCCCCAGACGCTGGCGGGCGTGCTCGATATCGACGCCAGCCGCAAGGGCGCGCGCTTCGT
CCGCTTCTGCGACGCCTTCGAGATCCCGATCGTCACCTTCGTCGACGTGCCGGGCTTCATGCCGGGCACCAAGCAGGAGC
AGGGCGGCCTGATCCGTCACGGCGCCAAGCTGCTGTTCGCCTACGCCGAGGCCACGGTGCCGAAGATCACCCTGATCACC
CGTAAGGCCTACGGCGGCGCCTACGACGTGATGAGCTCCAAGCACATCCGCGGCGACGTGAACTACGCCTGGCCGACCGC
CGAGATCGCGGTCATGGGCTCGAAGGGGGCGGTGGAGATCATCTTCCGCGCCGAGATTGGCGACCCCGACGCCATCGCCG
CGCGGGAGGCCGAGTACAAGGCCCGTTTCGCCAATCCGTTCGTCGCCGCCTCGCGGGGCTACATCGACGACGTGATCATG
CCCCACGGCACCCGCCGGCGGATCGTGCGGGCGCTCAAGAGCTTGAAGGGCAAGCAGCTCCAGAACCCCTGGAAGAAGCA
CGACAACATTCCGCTCTGA

Upstream 100 bases:

>100_bases
CGGATCAGCGCCTTCGCCTGAACCCCGCCCGCGGCTCACCCCGCGTGAGCTTGCGTGGGCGGATGGTCCCGACTACGCCT
TCCCCCACTTAGGTGAGGGG

Downstream 100 bases:

>100_bases
GACGCGGAACGACCGTCGCCGTCCCTTGTTCTGCCAATGAGGCGGGCGCGCGCCCGCAGGCCCTGCAGAACAGGAGGATT
CCCCATGCCCGACCGGTGGA

Product: propionyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MFVKHILEELEKRRAEARLGGGEKRIAAQHAKGKLTARERIDLLLDEGSFEEFDMFVEHRVTEFGMEKQRIPGDGVVTGW
GTINGRVVYVFSKDFTVFGGSLSSAHAEKILKVQRQALKVGAPIIGLFDAGGARIQEGVAALGGYADIFLENTLASGVIP
QISVIMGPCAGGDVYSPAITDFIFMVKDTSYMYVTGPDVVKTVTHEEVSHEELGGYRVHALKSGVADGAFENDLEALTQV
RRLVDFLPLSNREKPPVRTSFDDPEREEASLDTLVPANPNKPYDMKELILKVVDEADFFEISPDFAKNIVVGFARMDGQT
VGIVANQPQTLAGVLDIDASRKGARFVRFCDAFEIPIVTFVDVPGFMPGTKQEQGGLIRHGAKLLFAYAEATVPKITLIT
RKAYGGAYDVMSSKHIRGDVNYAWPTAEIAVMGSKGAVEIIFRAEIGDPDAIAAREAEYKARFANPFVAASRGYIDDVIM
PHGTRRRIVRALKSLKGKQLQNPWKKHDNIPL

Sequences:

>Translated_512_residues
MFVKHILEELEKRRAEARLGGGEKRIAAQHAKGKLTARERIDLLLDEGSFEEFDMFVEHRVTEFGMEKQRIPGDGVVTGW
GTINGRVVYVFSKDFTVFGGSLSSAHAEKILKVQRQALKVGAPIIGLFDAGGARIQEGVAALGGYADIFLENTLASGVIP
QISVIMGPCAGGDVYSPAITDFIFMVKDTSYMYVTGPDVVKTVTHEEVSHEELGGYRVHALKSGVADGAFENDLEALTQV
RRLVDFLPLSNREKPPVRTSFDDPEREEASLDTLVPANPNKPYDMKELILKVVDEADFFEISPDFAKNIVVGFARMDGQT
VGIVANQPQTLAGVLDIDASRKGARFVRFCDAFEIPIVTFVDVPGFMPGTKQEQGGLIRHGAKLLFAYAEATVPKITLIT
RKAYGGAYDVMSSKHIRGDVNYAWPTAEIAVMGSKGAVEIIFRAEIGDPDAIAAREAEYKARFANPFVAASRGYIDDVIM
PHGTRRRIVRALKSLKGKQLQNPWKKHDNIPL
>Mature_512_residues
MFVKHILEELEKRRAEARLGGGEKRIAAQHAKGKLTARERIDLLLDEGSFEEFDMFVEHRVTEFGMEKQRIPGDGVVTGW
GTINGRVVYVFSKDFTVFGGSLSSAHAEKILKVQRQALKVGAPIIGLFDAGGARIQEGVAALGGYADIFLENTLASGVIP
QISVIMGPCAGGDVYSPAITDFIFMVKDTSYMYVTGPDVVKTVTHEEVSHEELGGYRVHALKSGVADGAFENDLEALTQV
RRLVDFLPLSNREKPPVRTSFDDPEREEASLDTLVPANPNKPYDMKELILKVVDEADFFEISPDFAKNIVVGFARMDGQT
VGIVANQPQTLAGVLDIDASRKGARFVRFCDAFEIPIVTFVDVPGFMPGTKQEQGGLIRHGAKLLFAYAEATVPKITLIT
RKAYGGAYDVMSSKHIRGDVNYAWPTAEIAVMGSKGAVEIIFRAEIGDPDAIAAREAEYKARFANPFVAASRGYIDDVIM
PHGTRRRIVRALKSLKGKQLQNPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=65.8777120315582, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=63.3776091081594, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=508, Percent_Identity=33.6614173228346, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679974, Length=391, Percent_Identity=25.5754475703325, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679971, Length=391, Percent_Identity=25.5754475703325, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679960, Length=391, Percent_Identity=25.5754475703325, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679977, Length=391, Percent_Identity=25.5754475703325, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=391, Percent_Identity=25.5754475703325, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI134142062, Length=396, Percent_Identity=23.989898989899, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=64.4970414201183, Blast_Score=706, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=64.4970414201183, Blast_Score=705, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=525, Percent_Identity=33.3333333333333, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71997163, Length=325, Percent_Identity=26.1538461538462, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=33.2688588007737, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56187; Mature: 56187

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVKHILEELEKRRAEARLGGGEKRIAAQHAKGKLTARERIDLLLDEGSFEEFDMFVEHR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHH
VTEFGMEKQRIPGDGVVTGWGTINGRVVYVFSKDFTVFGGSLSSAHAEKILKVQRQALKV
HHHHCCHHHCCCCCCEEEEEECCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHH
GAPIIGLFDAGGARIQEGVAALGGYADIFLENTLASGVIPQISVIMGPCAGGDVYSPAIT
CCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHH
DFIFMVKDTSYMYVTGPDVVKTVTHEEVSHEELGGYRVHALKSGVADGAFENDLEALTQV
HEEEEEECCCEEEEECCHHHHHHHHHHCCHHHCCCEEEEEHHCCCCCCCHHHHHHHHHHH
RRLVDFLPLSNREKPPVRTSFDDPEREEASLDTLVPANPNKPYDMKELILKVVDEADFFE
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCEECCCCCCCCCCHHHHHHHHHCCCCCEE
ISPDFAKNIVVGFARMDGQTVGIVANQPQTLAGVLDIDASRKGARFVRFCDAFEIPIVTF
ECHHHHHHHEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEE
VDVPGFMPGTKQEQGGLIRHGAKLLFAYAEATVPKITLITRKAYGGAYDVMSSKHIRGDV
EECCCCCCCCCCCCCCHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCC
NYAWPTAEIAVMGSKGAVEIIFRAEIGDPDAIAAREAEYKARFANPFVAASRGYIDDVIM
CEECCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHCC
PHGTRRRIVRALKSLKGKQLQNPWKKHDNIPL
CCCHHHHHHHHHHHHCCCHHCCHHHHCCCCCC
>Mature Secondary Structure
MFVKHILEELEKRRAEARLGGGEKRIAAQHAKGKLTARERIDLLLDEGSFEEFDMFVEHR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHH
VTEFGMEKQRIPGDGVVTGWGTINGRVVYVFSKDFTVFGGSLSSAHAEKILKVQRQALKV
HHHHCCHHHCCCCCCEEEEEECCCCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHH
GAPIIGLFDAGGARIQEGVAALGGYADIFLENTLASGVIPQISVIMGPCAGGDVYSPAIT
CCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHH
DFIFMVKDTSYMYVTGPDVVKTVTHEEVSHEELGGYRVHALKSGVADGAFENDLEALTQV
HEEEEEECCCEEEEECCHHHHHHHHHHCCHHHCCCEEEEEHHCCCCCCCHHHHHHHHHHH
RRLVDFLPLSNREKPPVRTSFDDPEREEASLDTLVPANPNKPYDMKELILKVVDEADFFE
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCEECCCCCCCCCCHHHHHHHHHCCCCCEE
ISPDFAKNIVVGFARMDGQTVGIVANQPQTLAGVLDIDASRKGARFVRFCDAFEIPIVTF
ECHHHHHHHEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEE
VDVPGFMPGTKQEQGGLIRHGAKLLFAYAEATVPKITLITRKAYGGAYDVMSSKHIRGDV
EECCCCCCCCCCCCCCHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCC
NYAWPTAEIAVMGSKGAVEIIFRAEIGDPDAIAAREAEYKARFANPFVAASRGYIDDVIM
CEECCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHCC
PHGTRRRIVRALKSLKGKQLQNPWKKHDNIPL
CCCHHHHHHHHHHHHCCCHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]