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The map label for this gene is tetA [H]

Identifier: 197104726

GI number: 197104726

Start: 1436299

End: 1437552

Strand: Direct

Name: tetA [H]

Synonym: PHZ_c1260

Alternate gene names: 197104726

Gene position: 1436299-1437552 (Clockwise)

Preceding gene: 197104725

Following gene: 197104727

Centisome position: 35.94

GC content: 70.97

Gene sequence:

>1254_bases
ATGTCCAACCTGACCACGCCGCCCGGGCCGAAGGCGCGGCGGGCCGGCTTCGGGTTCATCTTCGCGCTGGCGCTGATGAA
CTCGATCTCGTTCGGGATCATGATCCCGATCCTGCCGAACCTCATCAAGGAGTTCGCCGGCGGCGACACCGCGGCGGCGT
CGGAATGGAACCTGCTCTTCGCCAGCGCCTGGGGCCTGATGCAGTTCTTCACCGGCCCGATCCTCGGGCTGATGTCGGAC
CGCTGGGGCCGCAGGCCGGTGCTGCTGATCTCGCTGTTCGGCTTGGGCGTCGACTTCCTGTTCATGGCCTTGGCGCCGAG
TCTCGCCTGGCTGTTCCTGGGGCGCCTTCTGAACGGGGCGACGGCGGCCAGCTTCTCGACCGCCAACGCCTATCTCGCGG
ACGTCACGGCGCCGCAGGAGCGGGCGCGGCTGTTCGGCCTGCTGGGGGCCTCGTTCAGCGTCGGCTTCATCTTCGGTCCC
GCGATCGGCGGCTTCCTGGGCGAGATCAACCTGCGGCTGCCCTTCGTGGCCGCGGCCGGCCTGACCCTGGTGAACTGGCT
GTACGGCCTCCTGGTCCTGCCCGAGTCGCTGCCGCCCGAGCGCCGGGCGGCGCGCTTCGACTGGACGCGGGCCAATCCGG
TGGGATCGCTGCGGCTGCTGCGGTCCAAGCGCGACCTGCTGGGGCTGGCCGGCATCGGCTTCCTGTTCCAGGTGGCGCAC
ATGGTCTTCCCCACCATCTTCGTCCTCTACGTGGGATACCGGTACGGCTGGACGCCCCAGACCATGGGGCTGATGTTCCT
GCTCACCGGGGTGGCGGGGCTGGTCGTGCAGAGTCTGCTGGTGGGGCCGGTCGTGCGGCGGGTGGGCGAGCGCAACGCGG
TCCTCCTCGGCGCCGCCGGCGGGGCCCTGGGCCTCGTCTGGTACGGCAGCGCGCCGACCGGAGCCATGGCCGTCGCCGGC
ATCCCGATCTTCGCGCTGTCGGGCTTCCTCATGCCGGGCGTGCAGGGGCTGATGACCCGCCGCGTCGAGCCCCACCAGCA
GGGACAGCTGCAGGGCGCCAACCAGAGCCTCACGGGGGTGGCCGCCATCCTCGGACCGATCGTGTTCGGCGAGACCTTCG
CCTGGTCGCTGCGGAACCAGGCCTTCCAGGCGCCGGGCTTGGCCATGTATGTGGCGGGAGCCCTGCTGGCGCTGGCCTTC
GTCATCGCCCTCGGCGCGGCGAAGGCGCCCGAGCCCGAGGCGATCGCCGCATGA

Upstream 100 bases:

>100_bases
CCGAGTGGTGGCGCGACTTGCTGGAGGGCCTGGCGGCACGGGCTTAGCGACGTTGCGCGCGCCGCCGGTGCGGGCCAACC
TTGGGGAGAGGGAGATCGGC

Downstream 100 bases:

>100_bases
GCTTCGCCATCTTTGCGCCTGAAACCTCGGCAGATTTCCGCCGTTGATCGGCTTTCCGGAGACCGCATGCGCGCCACCCG
CGTCCTGATCCCCGCCTGCG

Product: tetracycline resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSNLTTPPGPKARRAGFGFIFALALMNSISFGIMIPILPNLIKEFAGGDTAAASEWNLLFASAWGLMQFFTGPILGLMSD
RWGRRPVLLISLFGLGVDFLFMALAPSLAWLFLGRLLNGATAASFSTANAYLADVTAPQERARLFGLLGASFSVGFIFGP
AIGGFLGEINLRLPFVAAAGLTLVNWLYGLLVLPESLPPERRAARFDWTRANPVGSLRLLRSKRDLLGLAGIGFLFQVAH
MVFPTIFVLYVGYRYGWTPQTMGLMFLLTGVAGLVVQSLLVGPVVRRVGERNAVLLGAAGGALGLVWYGSAPTGAMAVAG
IPIFALSGFLMPGVQGLMTRRVEPHQQGQLQGANQSLTGVAAILGPIVFGETFAWSLRNQAFQAPGLAMYVAGALLALAF
VIALGAAKAPEPEAIAA

Sequences:

>Translated_417_residues
MSNLTTPPGPKARRAGFGFIFALALMNSISFGIMIPILPNLIKEFAGGDTAAASEWNLLFASAWGLMQFFTGPILGLMSD
RWGRRPVLLISLFGLGVDFLFMALAPSLAWLFLGRLLNGATAASFSTANAYLADVTAPQERARLFGLLGASFSVGFIFGP
AIGGFLGEINLRLPFVAAAGLTLVNWLYGLLVLPESLPPERRAARFDWTRANPVGSLRLLRSKRDLLGLAGIGFLFQVAH
MVFPTIFVLYVGYRYGWTPQTMGLMFLLTGVAGLVVQSLLVGPVVRRVGERNAVLLGAAGGALGLVWYGSAPTGAMAVAG
IPIFALSGFLMPGVQGLMTRRVEPHQQGQLQGANQSLTGVAAILGPIVFGETFAWSLRNQAFQAPGLAMYVAGALLALAF
VIALGAAKAPEPEAIAA
>Mature_416_residues
SNLTTPPGPKARRAGFGFIFALALMNSISFGIMIPILPNLIKEFAGGDTAAASEWNLLFASAWGLMQFFTGPILGLMSDR
WGRRPVLLISLFGLGVDFLFMALAPSLAWLFLGRLLNGATAASFSTANAYLADVTAPQERARLFGLLGASFSVGFIFGPA
IGGFLGEINLRLPFVAAAGLTLVNWLYGLLVLPESLPPERRAARFDWTRANPVGSLRLLRSKRDLLGLAGIGFLFQVAHM
VFPTIFVLYVGYRYGWTPQTMGLMFLLTGVAGLVVQSLLVGPVVRRVGERNAVLLGAAGGALGLVWYGSAPTGAMAVAGI
PIFALSGFLMPGVQGLMTRRVEPHQQGQLQGANQSLTGVAAILGPIVFGETFAWSLRNQAFQAPGLAMYVAGALLALAFV
IALGAAKAPEPEAIAA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=322, Percent_Identity=29.8136645962733, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI94721311, Length=314, Percent_Identity=29.9363057324841, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI225703104, Length=344, Percent_Identity=27.3255813953488, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI225703102, Length=344, Percent_Identity=27.3255813953488, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI217416366, Length=403, Percent_Identity=25.5583126550869, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787291, Length=347, Percent_Identity=23.6311239193084, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=319, Percent_Identity=26.9592476489028, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17551570, Length=423, Percent_Identity=21.7494089834515, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357569, Length=314, Percent_Identity=27.7070063694268, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17738085, Length=379, Percent_Identity=29.8153034300792, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656463, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656468, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161080926, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161080924, Length=314, Percent_Identity=27.7070063694268, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221513297, Length=318, Percent_Identity=27.9874213836478, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667557, Length=166, Percent_Identity=26.5060240963855, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667561, Length=156, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44057; Mature: 43925

Theoretical pI: Translated: 10.93; Mature: 10.93

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLTTPPGPKARRAGFGFIFALALMNSISFGIMIPILPNLIKEFAGGDTAAASEWNLLF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ASAWGLMQFFTGPILGLMSDRWGRRPVLLISLFGLGVDFLFMALAPSLAWLFLGRLLNGA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TAASFSTANAYLADVTAPQERARLFGLLGASFSVGFIFGPAIGGFLGEINLRLPFVAAAG
HHCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEHHHHHHH
LTLVNWLYGLLVLPESLPPERRAARFDWTRANPVGSLRLLRSKRDLLGLAGIGFLFQVAH
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MVFPTIFVLYVGYRYGWTPQTMGLMFLLTGVAGLVVQSLLVGPVVRRVGERNAVLLGAAG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GALGLVWYGSAPTGAMAVAGIPIFALSGFLMPGVQGLMTRRVEPHQQGQLQGANQSLTGV
CCEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AAILGPIVFGETFAWSLRNQAFQAPGLAMYVAGALLALAFVIALGAAKAPEPEAIAA
HHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNLTTPPGPKARRAGFGFIFALALMNSISFGIMIPILPNLIKEFAGGDTAAASEWNLLF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ASAWGLMQFFTGPILGLMSDRWGRRPVLLISLFGLGVDFLFMALAPSLAWLFLGRLLNGA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TAASFSTANAYLADVTAPQERARLFGLLGASFSVGFIFGPAIGGFLGEINLRLPFVAAAG
HHCCCCCCCHHEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEHHHHHHH
LTLVNWLYGLLVLPESLPPERRAARFDWTRANPVGSLRLLRSKRDLLGLAGIGFLFQVAH
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MVFPTIFVLYVGYRYGWTPQTMGLMFLLTGVAGLVVQSLLVGPVVRRVGERNAVLLGAAG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GALGLVWYGSAPTGAMAVAGIPIFALSGFLMPGVQGLMTRRVEPHQQGQLQGANQSLTGV
CCEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AAILGPIVFGETFAWSLRNQAFQAPGLAMYVAGALLALAFVIALGAAKAPEPEAIAA
HHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]