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The map label for this gene is fabG [C]

Identifier: 197104347

GI number: 197104347

Start: 974963

End: 975865

Strand: Reverse

Name: fabG [C]

Synonym: PHZ_c0881

Alternate gene names: 197104347

Gene position: 975865-974963 (Counterclockwise)

Preceding gene: 197104348

Following gene: 197104346

Centisome position: 24.42

GC content: 69.55

Gene sequence:

>903_bases
ATGGCGGACATCCGCTTCGACGGCAAAGTGGCCATCGTGACCGGCGCGGGCGGGGGCCTCGGCCGCCAGCACGCGCTGGA
GCTCGCCCGGCGCGGCGCAAAGGTCGTGGTCAACGACCTGGGCGGCTCGGTGGACGGCTCGGGCGGCGGCTCGGACGCGG
CCAACAAGGTCGTCGAGGAGATCAAGGCCGCCGGCGGCGAGGCGATCGCCAACGGCTCGTCGGTGACCGACGACGCCGGC
GTGGCCCGGATGGTCAAGGACGCCATGGACGCCTGGGGCCGGATCGACATCCTGGTCGCCAACGCCGGCATCCTGCGCGA
CAAGACCTTCGCCAAGATGGAGCTGGCCGACTTCGAGGTCGTGGTCGACGTCCACCTGCTGGGCACGGTGAAGCCGGCCA
AGGCGGTCTGGGAGATCATGCGCCAGCAGAACTACGGCCGCATCGTCGTCACCACCTCCTCGACCGGCCTCTACGGCAAC
TTCGGCCAGTCGAACTACGGCGCGGCCAAGCTGGGCCTGGTGGGCTTCATGAACACGCTGAAGCTCGAGGGCCAGAAGAA
CAACATCCACGTCAACGCCATCAGCCCGGTGGCCGCGACCCGGATGACCGAGAACCTGATGCCGCCCCAGGTGCTGGAGC
AGCTGAAGCCCGAGTACGTGACCCCCGGCGTGGTGTTCCTGTGCTCGGAAGAGGCCCCGACCGGCACGGTCCTGACCGCC
GGCGCCGGCGCCTTCGCCGTGGCGCGGATCGTCGAGACCGAGGGCGTCTACCTGGGCGGGACCGCCACGGTCGAGCAGGT
GCGCGACAACTTCGCCAAGATCGCCGATCCGGCGGGCCAGCAGGCCTACATGAACGGCGGCGAGCAGACGGCGAAGTTCT
TCCGCAAGATGCAGGGCGGCTGA

Upstream 100 bases:

>100_bases
AAAGCGCCGCGCCTCCGCCACGTCAGCTTGACGCCCCTCGCGCCGCGCCGCACAACGCGCGCCGACTTTTCCGAACACCT
GTTCTAGAGGGGACACGCAA

Downstream 100 bases:

>100_bases
TCGCCCGCACGGCGACCTGACGTTCGGGCGGCCATCTGGCCGCCCGTTTCGTATCTGAAACCGGAAACCGCTTGCGCGGG
CTCAAGTGATCGCGCGTAAC

Product: HlyD family secretion protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSVDGSGGGSDAANKVVEEIKAAGGEAIANGSSVTDDAG
VARMVKDAMDAWGRIDILVANAGILRDKTFAKMELADFEVVVDVHLLGTVKPAKAVWEIMRQQNYGRIVVTTSSTGLYGN
FGQSNYGAAKLGLVGFMNTLKLEGQKNNIHVNAISPVAATRMTENLMPPQVLEQLKPEYVTPGVVFLCSEEAPTGTVLTA
GAGAFAVARIVETEGVYLGGTATVEQVRDNFAKIADPAGQQAYMNGGEQTAKFFRKMQGG

Sequences:

>Translated_300_residues
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSVDGSGGGSDAANKVVEEIKAAGGEAIANGSSVTDDAG
VARMVKDAMDAWGRIDILVANAGILRDKTFAKMELADFEVVVDVHLLGTVKPAKAVWEIMRQQNYGRIVVTTSSTGLYGN
FGQSNYGAAKLGLVGFMNTLKLEGQKNNIHVNAISPVAATRMTENLMPPQVLEQLKPEYVTPGVVFLCSEEAPTGTVLTA
GAGAFAVARIVETEGVYLGGTATVEQVRDNFAKIADPAGQQAYMNGGEQTAKFFRKMQGG
>Mature_299_residues
ADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSVDGSGGGSDAANKVVEEIKAAGGEAIANGSSVTDDAGV
ARMVKDAMDAWGRIDILVANAGILRDKTFAKMELADFEVVVDVHLLGTVKPAKAVWEIMRQQNYGRIVVTTSSTGLYGNF
GQSNYGAAKLGLVGFMNTLKLEGQKNNIHVNAISPVAATRMTENLMPPQVLEQLKPEYVTPGVVFLCSEEAPTGTVLTAG
AGAFAVARIVETEGVYLGGTATVEQVRDNFAKIADPAGQQAYMNGGEQTAKFFRKMQGG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=279, Percent_Identity=50.5376344086022, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=31.5573770491803, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=29.6577946768061, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4503817, Length=192, Percent_Identity=28.125, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI40807363, Length=224, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI25282469, Length=241, Percent_Identity=27.3858921161826, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7657478, Length=198, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=28.1746031746032, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI157739938, Length=189, Percent_Identity=24.8677248677249, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=26.3565891472868, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=33.984375, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=29.9212598425197, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082100, Length=204, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789057, Length=216, Percent_Identity=31.4814814814815, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=26.7489711934156, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082160, Length=196, Percent_Identity=29.0816326530612, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=291, Percent_Identity=47.4226804123711, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25147288, Length=211, Percent_Identity=32.2274881516588, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=31.5175097276265, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17567345, Length=316, Percent_Identity=26.2658227848101, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=228, Percent_Identity=28.5087719298246, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=229, Percent_Identity=29.2576419213974, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=29.0155440414508, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=231, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=246, Percent_Identity=26.4227642276423, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=237, Percent_Identity=25.3164556962025, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=201, Percent_Identity=28.8557213930348, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=26.6331658291457, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=205, Percent_Identity=29.2682926829268, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=209, Percent_Identity=31.1004784688995, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=278, Percent_Identity=47.841726618705, Blast_Score=255, Evalue=6e-69,
Organism=Drosophila melanogaster, GI18859837, Length=278, Percent_Identity=47.1223021582734, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24639444, Length=238, Percent_Identity=31.0924369747899, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640492, Length=239, Percent_Identity=24.6861924686192, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=29.5336787564767, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355631, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581726, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=30.0518134715026, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357041, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=199, Percent_Identity=29.1457286432161, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580925, Length=210, Percent_Identity=28.0952380952381, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31333; Mature: 31202

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSVDGSGGGSDAANKVVEE
CCCEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
IKAAGGEAIANGSSVTDDAGVARMVKDAMDAWGRIDILVANAGILRDKTFAKMELADFEV
HHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCHHEEECCCEEE
VVDVHLLGTVKPAKAVWEIMRQQNYGRIVVTTSSTGLYGNFGQSNYGAAKLGLVGFMNTL
EEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHE
KLEGQKNNIHVNAISPVAATRMTENLMPPQVLEQLKPEYVTPGVVFLCSEEAPTGTVLTA
EECCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEC
GAGAFAVARIVETEGVYLGGTATVEQVRDNFAKIADPAGQQAYMNGGEQTAKFFRKMQGG
CCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ADIRFDGKVAIVTGAGGGLGRQHALELARRGAKVVVNDLGGSVDGSGGGSDAANKVVEE
CCEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
IKAAGGEAIANGSSVTDDAGVARMVKDAMDAWGRIDILVANAGILRDKTFAKMELADFEV
HHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEECCCCHHEEECCCEEE
VVDVHLLGTVKPAKAVWEIMRQQNYGRIVVTTSSTGLYGNFGQSNYGAAKLGLVGFMNTL
EEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHE
KLEGQKNNIHVNAISPVAATRMTENLMPPQVLEQLKPEYVTPGVVFLCSEEAPTGTVLTA
EECCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEC
GAGAFAVARIVETEGVYLGGTATVEQVRDNFAKIADPAGQQAYMNGGEQTAKFFRKMQGG
CCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]