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The map label for this gene is lktA [H]

Identifier: 197104321

GI number: 197104321

Start: 946758

End: 947933

Strand: Reverse

Name: lktA [H]

Synonym: PHZ_c0855

Alternate gene names: 197104321

Gene position: 947933-946758 (Counterclockwise)

Preceding gene: 197104322

Following gene: 197104317

Centisome position: 23.72

GC content: 73.72

Gene sequence:

>1176_bases
ATGAGCGCTGGGACCTACTCAGACCTTCTTCGCGCGCTCGGGCAGAACGAGTCCGGGAACAACTACGCCTTCGTGAGCAG
CCTGGGCTACCTGGGCCGCTTCCAGTTCGGCGAGGAGGCCCTCCAGGCCATCGGCTTCTACCAGGGCGACGGCAATCCCT
ACGCCATCGACTTCGTGGGCGCCTGGACCGAGACGGCCCACGGCTACGGCGTCTGGGACAAGGCGAGCTTCCTCGCCACG
CCGGCGGCCCAGGACGCGGCCGCCGACGCCTGGTTCGGCAAGGTGTGGCAGGACGCCGCGGCGCTGAACCTGCAGAGCTA
CATCGGCCAGTGGGTGGCGGGCGTGGAGGTGACCCCTTCGGGCATCCTGGCCGGCGCGCACCTCGTGGGCGTCTGGAACC
TGAAGTCCTGGCTGGAGAGCGGCGGGGCGGTCGACACCCGCGACGGCTACGGCACGCCGGTCTCGCAGTACGTCGGCAAG
TTCGGCGGCTACGACACGCCCTTCGCCCCCGCCGGGGGCGAAGGTGGCGGCGGAAGCGGCGGCGGCGGCGCGGGCGACGG
CGCCGCGGGCCAGTTCCTGCAGGGCGGCGACGGGGCCGACCACCTCGCGGGCGGCGGCGGCGCCGACACCCTCGAGGGCG
GCGCCGGGGTCAACGTCCTGCGCGGCGGCGCGGGCGGCGACAGCCTGCAGGGCGGCTGGCAGTTCGACGACCTGCACGGC
AACACCGGGAACGACACCGTGGCCGGCGGTTCGGGCGACGACTGGGTCGTGGGCGGCCAGGACGACGACCTGCTGTTCGG
CGACGACGGCGGGGACGTGGTGCTCGGCAACCTCGGCCAGGACACCGCTGACGGCGGCGGCGGGAACGACGTGGTCCGCG
GCGGCCAGGGCGACGACAGCCTGACCGGCGGCTGGGGCGACGACTTCCTGGCCGGCGACCGGGGCTCCGACACCCTCGCG
GGCGGCGGCGGGGCCGACACCTTCCACGTCTTCCAGGGCTCGGGGCTGGACCTCGTGCTGGACTTCAATCCCTGGGAGGG
CGACCGCGTCGACGCGCTGGGCCCCTACTCCACCTACCAGAGCGACGCCGGGGCGGTCGTGGACATGGGCGGCGACAGCC
GGATGGTGCTGCAGGGCGTGCAGCTCTCGTCGCTGCCCGAAGGCTGGATCGTCTAG

Upstream 100 bases:

>100_bases
CGTTCACCACCAAGTTGAAGCTCCGCGACCCTCCGGGGCGCGAGGGCGACGCCTTGCGGGCGGACGACGGCGTGCGGCCT
AGTCGAGGGAAACACCGGAA

Downstream 100 bases:

>100_bases
CGGGCCTTGCGCAGGCCGAGTTCGTCCAGCGCCGCGGTCTCGCGGCGGCCCTGCGCCTTCACTTCGAGCAGGCGGGCGGA
CTCGGCCACCTGCTCGTACT

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSAGTYSDLLRALGQNESGNNYAFVSSLGYLGRFQFGEEALQAIGFYQGDGNPYAIDFVGAWTETAHGYGVWDKASFLAT
PAAQDAAADAWFGKVWQDAAALNLQSYIGQWVAGVEVTPSGILAGAHLVGVWNLKSWLESGGAVDTRDGYGTPVSQYVGK
FGGYDTPFAPAGGEGGGGSGGGGAGDGAAGQFLQGGDGADHLAGGGGADTLEGGAGVNVLRGGAGGDSLQGGWQFDDLHG
NTGNDTVAGGSGDDWVVGGQDDDLLFGDDGGDVVLGNLGQDTADGGGGNDVVRGGQGDDSLTGGWGDDFLAGDRGSDTLA
GGGGADTFHVFQGSGLDLVLDFNPWEGDRVDALGPYSTYQSDAGAVVDMGGDSRMVLQGVQLSSLPEGWIV

Sequences:

>Translated_391_residues
MSAGTYSDLLRALGQNESGNNYAFVSSLGYLGRFQFGEEALQAIGFYQGDGNPYAIDFVGAWTETAHGYGVWDKASFLAT
PAAQDAAADAWFGKVWQDAAALNLQSYIGQWVAGVEVTPSGILAGAHLVGVWNLKSWLESGGAVDTRDGYGTPVSQYVGK
FGGYDTPFAPAGGEGGGGSGGGGAGDGAAGQFLQGGDGADHLAGGGGADTLEGGAGVNVLRGGAGGDSLQGGWQFDDLHG
NTGNDTVAGGSGDDWVVGGQDDDLLFGDDGGDVVLGNLGQDTADGGGGNDVVRGGQGDDSLTGGWGDDFLAGDRGSDTLA
GGGGADTFHVFQGSGLDLVLDFNPWEGDRVDALGPYSTYQSDAGAVVDMGGDSRMVLQGVQLSSLPEGWIV
>Mature_390_residues
SAGTYSDLLRALGQNESGNNYAFVSSLGYLGRFQFGEEALQAIGFYQGDGNPYAIDFVGAWTETAHGYGVWDKASFLATP
AAQDAAADAWFGKVWQDAAALNLQSYIGQWVAGVEVTPSGILAGAHLVGVWNLKSWLESGGAVDTRDGYGTPVSQYVGKF
GGYDTPFAPAGGEGGGGSGGGGAGDGAAGQFLQGGDGADHLAGGGGADTLEGGAGVNVLRGGAGGDSLQGGWQFDDLHGN
TGNDTVAGGSGDDWVVGGQDDDLLFGDDGGDVVLGNLGQDTADGGGGNDVVRGGQGDDSLTGGWGDDFLAGDRGSDTLAG
GGGADTFHVFQGSGLDLVLDFNPWEGDRVDALGPYSTYQSDAGAVVDMGGDSRMVLQGVQLSSLPEGWIV

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 39267; Mature: 39136

Theoretical pI: Translated: 3.63; Mature: 3.63

Prosite motif: PS01098 LIPASE_GDSL_SER ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGTYSDLLRALGQNESGNNYAFVSSLGYLGRFQFGEEALQAIGFYQGDGNPYAIDFVG
CCCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCEEEEEEEE
AWTETAHGYGVWDKASFLATPAAQDAAADAWFGKVWQDAAALNLQSYIGQWVAGVEVTPS
CCHHCCCCCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GILAGAHLVGVWNLKSWLESGGAVDTRDGYGTPVSQYVGKFGGYDTPFAPAGGEGGGGSG
CEEECCEEEEEHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGGAGDGAAGQFLQGGDGADHLAGGGGADTLEGGAGVNVLRGGAGGDSLQGGWQFDDLHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCC
NTGNDTVAGGSGDDWVVGGQDDDLLFGDDGGDVVLGNLGQDTADGGGGNDVVRGGQGDDS
CCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCC
LTGGWGDDFLAGDRGSDTLAGGGGADTFHVFQGSGLDLVLDFNPWEGDRVDALGPYSTYQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHCC
SDAGAVVDMGGDSRMVLQGVQLSSLPEGWIV
CCCCEEEEECCCCEEEEECCCHHCCCCCCCC
>Mature Secondary Structure 
SAGTYSDLLRALGQNESGNNYAFVSSLGYLGRFQFGEEALQAIGFYQGDGNPYAIDFVG
CCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCEEEEEEEE
AWTETAHGYGVWDKASFLATPAAQDAAADAWFGKVWQDAAALNLQSYIGQWVAGVEVTPS
CCHHCCCCCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
GILAGAHLVGVWNLKSWLESGGAVDTRDGYGTPVSQYVGKFGGYDTPFAPAGGEGGGGSG
CEEECCEEEEEHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGGAGDGAAGQFLQGGDGADHLAGGGGADTLEGGAGVNVLRGGAGGDSLQGGWQFDDLHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCC
NTGNDTVAGGSGDDWVVGGQDDDLLFGDDGGDVVLGNLGQDTADGGGGNDVVRGGQGDDS
CCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCC
LTGGWGDDFLAGDRGSDTLAGGGGADTFHVFQGSGLDLVLDFNPWEGDRVDALGPYSTYQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHCC
SDAGAVVDMGGDSRMVLQGVQLSSLPEGWIV
CCCCEEEEECCCCEEEEECCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]