Click here to switch to the map view.

The map label for this gene is gcvPA

Identifier: 197104056

GI number: 197104056

Start: 624456

End: 625784

Strand: Reverse

Name: gcvPA

Synonym: PHZ_c0590

Alternate gene names: 197104056

Gene position: 625784-624456 (Counterclockwise)

Preceding gene: 197104057

Following gene: 197104055

Centisome position: 15.66

GC content: 72.46

Gene sequence:

>1329_bases
ATGAGATACCTGCCCCTCACCCCCGAAGACCGCGCGCAGATGCTCGGCGTCATCGGGGCGCCCGACGTGGACGCGCTGTT
CGCCGACGTGCCGGCGGCCGCGCGCAATCCGGCCATCGGCCTTGCGCCGCACGCGGGCGAGCTGGAGGTGGAGCGCGAGC
TTTCCGGCCTCGCCGCCCTCAACCGCGCCGCCGGGGCGGGGCCGTTCTTCTGCGGCGCCGGCGCCTACCGCCACCACGTG
CCGGCCACCGTGGACCACATCATCCAGCGGTCCGAGTTCCTGACCAGCTACACGCCCTACCAGCCCGAGATCGCCCAGGG
CACGCTGCAGGTCCTGTTCGAGTTCCAGACCCAGGTCGCGCGCCTGACCGGCCTCGATGTGGCCAACGCCTCGATGTACG
ACGGCTCGACCGCCTGCGCCGAGGCCGTGATGATGGCCCAGCGGGTGACCCGCCGCGAGAAGGCGATCCTCTCGGGCGGC
CTGCATCCGCACTACGCCGCCACGACCCAGACCATCGCCCACGCCGAGGGCATGGAGATCGTCCGCCAGCCGGCCGCGAT
CGACGCCGAGGCCGCGGTCATCGAGGCGATCGACGCCGAGACCGCCTGCGTCGTCGTCCAGACCCCCAACGTCTTCGGCG
TGGTCACCGACGTGTCGAAGATCGCCGAGGCCGCCCACGCCAAGGGCGCCCTGCTGATCGTGGTCACGACCGAGGCCGTC
GCCTACGGCCTGCTGAAGTCGCCGGGCGAGATGGGCGCCGACATCGCCGTGGCCGAGGGCCAGTCGATCGGCAACGCGCT
GAACTACGGCGGCCCCTACGTCGGCCTCTTCGCCTGCCGCGAGAAGTTCGTCCGCAACATGCCCGGCCGCCTCTGCGGCG
AGACGGTCGACGCCGAGGGCCGGCGCGGCTACGTGCTGACGCTGTCGACCCGCGAGCAGCACATCCGCCGCGAGAAGGCG
ACCTCGAACATCTGCACCAACTCGGGGCTCTGCGCCCTGGCGTTCTCGATCCACCTGTCGCTGCTGGGCGGCAAGGGGCT
CTCCCAGCTCGCCCGGGTGAACCACGCCCGCGCCCGCGAGCTGAAGGCCGCCGTGGAGGCCGCGGGGCTCGAGGTGCTGA
CGCCGCGGTTCTTCAACGAGATCGCCGTGCGCACCAAGGGCCCGGCCGCCGACCTCGTCGAGCGCCTGCTGGCCGACGGC
GTCGTCGCCGGCGTGCCGTTCTCGCGCCTGGATCCCGGCGCGGGCCTGGACGACGTCCTGCTGCTCTGCGCCACCGAGAC
CACCACCTCCGACGACATCGCCGCGCTGAAGGACGCGCTCGCCCGATGA

Upstream 100 bases:

>100_bases
CCCAAGCCGAGCCTCGAGCGCCGCATGGGTCCCCCCGGATCGCTCCGCGACCGGGGGATGACGAAACGGAGGACGCCGCA
CGCCTGCTGGATCTGACCCG

Downstream 100 bases:

>100_bases
GCATGCTGAACGTGGGCCGCCCCACCCGCCCCGAGGCCGCCGAGCCCGCCCAGACCTCGCTGACCGGCGGCCGCGGCCTC
CTCCAGGACGAGCCGCTGCT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MRYLPLTPEDRAQMLGVIGAPDVDALFADVPAAARNPAIGLAPHAGELEVERELSGLAALNRAAGAGPFFCGAGAYRHHV
PATVDHIIQRSEFLTSYTPYQPEIAQGTLQVLFEFQTQVARLTGLDVANASMYDGSTACAEAVMMAQRVTRREKAILSGG
LHPHYAATTQTIAHAEGMEIVRQPAAIDAEAAVIEAIDAETACVVVQTPNVFGVVTDVSKIAEAAHAKGALLIVVTTEAV
AYGLLKSPGEMGADIAVAEGQSIGNALNYGGPYVGLFACREKFVRNMPGRLCGETVDAEGRRGYVLTLSTREQHIRREKA
TSNICTNSGLCALAFSIHLSLLGGKGLSQLARVNHARARELKAAVEAAGLEVLTPRFFNEIAVRTKGPAADLVERLLADG
VVAGVPFSRLDPGAGLDDVLLLCATETTTSDDIAALKDALAR

Sequences:

>Translated_442_residues
MRYLPLTPEDRAQMLGVIGAPDVDALFADVPAAARNPAIGLAPHAGELEVERELSGLAALNRAAGAGPFFCGAGAYRHHV
PATVDHIIQRSEFLTSYTPYQPEIAQGTLQVLFEFQTQVARLTGLDVANASMYDGSTACAEAVMMAQRVTRREKAILSGG
LHPHYAATTQTIAHAEGMEIVRQPAAIDAEAAVIEAIDAETACVVVQTPNVFGVVTDVSKIAEAAHAKGALLIVVTTEAV
AYGLLKSPGEMGADIAVAEGQSIGNALNYGGPYVGLFACREKFVRNMPGRLCGETVDAEGRRGYVLTLSTREQHIRREKA
TSNICTNSGLCALAFSIHLSLLGGKGLSQLARVNHARARELKAAVEAAGLEVLTPRFFNEIAVRTKGPAADLVERLLADG
VVAGVPFSRLDPGAGLDDVLLLCATETTTSDDIAALKDALAR
>Mature_442_residues
MRYLPLTPEDRAQMLGVIGAPDVDALFADVPAAARNPAIGLAPHAGELEVERELSGLAALNRAAGAGPFFCGAGAYRHHV
PATVDHIIQRSEFLTSYTPYQPEIAQGTLQVLFEFQTQVARLTGLDVANASMYDGSTACAEAVMMAQRVTRREKAILSGG
LHPHYAATTQTIAHAEGMEIVRQPAAIDAEAAVIEAIDAETACVVVQTPNVFGVVTDVSKIAEAAHAKGALLIVVTTEAV
AYGLLKSPGEMGADIAVAEGQSIGNALNYGGPYVGLFACREKFVRNMPGRLCGETVDAEGRRGYVLTLSTREQHIRREKA
TSNICTNSGLCALAFSIHLSLLGGKGLSQLARVNHARARELKAAVEAAGLEVLTPRFFNEIAVRTKGPAADLVERLLADG
VVAGVPFSRLDPGAGLDDVLLLCATETTTSDDIAALKDALAR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=433, Percent_Identity=33.9491916859122, Blast_Score=228, Evalue=9e-60,
Organism=Escherichia coli, GI1789269, Length=438, Percent_Identity=30.5936073059361, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535605, Length=395, Percent_Identity=37.4683544303797, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=396, Percent_Identity=33.8383838383838, Blast_Score=202, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24645648, Length=410, Percent_Identity=39.2682926829268, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_PHEZH (B4RF16)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129433.1
- GeneID:   6790081
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0590
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 46517; Mature: 46517

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTPEDRAQMLGVIGAPDVDALFADVPAAARNPAIGLAPHAGELEVERELSGLAAL
CCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHH
NRAAGAGPFFCGAGAYRHHVPATVDHIIQRSEFLTSYTPYQPEIAQGTLQVLFEFQTQVA
HHHCCCCCCEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RLTGLDVANASMYDGSTACAEAVMMAQRVTRREKAILSGGLHPHYAATTQTIAHAEGMEI
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VRQPAAIDAEAAVIEAIDAETACVVVQTPNVFGVVTDVSKIAEAAHAKGALLIVVTTEAV
HHCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEHHHHHHHHHHHHCCCCEEEEEEHHHH
AYGLLKSPGEMGADIAVAEGQSIGNALNYGGPYVGLFACREKFVRNMPGRLCGETVDAEG
HHHHHCCCCCCCCCEEEECCCHHCCHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCC
RRGYVLTLSTREQHIRREKATSNICTNSGLCALAFSIHLSLLGGKGLSQLARVNHARARE
CCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LKAAVEAAGLEVLTPRFFNEIAVRTKGPAADLVERLLADGVVAGVPFSRLDPGAGLDDVL
HHHHHHHCCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCHHHCCCCCCCCCEE
LLCATETTTSDDIAALKDALAR
EEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRYLPLTPEDRAQMLGVIGAPDVDALFADVPAAARNPAIGLAPHAGELEVERELSGLAAL
CCCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHH
NRAAGAGPFFCGAGAYRHHVPATVDHIIQRSEFLTSYTPYQPEIAQGTLQVLFEFQTQVA
HHHCCCCCCEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RLTGLDVANASMYDGSTACAEAVMMAQRVTRREKAILSGGLHPHYAATTQTIAHAEGMEI
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VRQPAAIDAEAAVIEAIDAETACVVVQTPNVFGVVTDVSKIAEAAHAKGALLIVVTTEAV
HHCCCCCCCHHHHHHHHCCCCEEEEEECCCEEEEHHHHHHHHHHHHCCCCEEEEEEHHHH
AYGLLKSPGEMGADIAVAEGQSIGNALNYGGPYVGLFACREKFVRNMPGRLCGETVDAEG
HHHHHCCCCCCCCCEEEECCCHHCCHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCC
RRGYVLTLSTREQHIRREKATSNICTNSGLCALAFSIHLSLLGGKGLSQLARVNHARARE
CCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LKAAVEAAGLEVLTPRFFNEIAVRTKGPAADLVERLLADGVVAGVPFSRLDPGAGLDDVL
HHHHHHHCCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCHHHCCCCCCCCCEE
LLCATETTTSDDIAALKDALAR
EEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA