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The map label for this gene is gcvP [H]

Identifier: 197104055

GI number: 197104055

Start: 622933

End: 624459

Strand: Reverse

Name: gcvP [H]

Synonym: PHZ_c0589

Alternate gene names: 197104055

Gene position: 624459-622933 (Counterclockwise)

Preceding gene: 197104056

Following gene: 197104054

Centisome position: 15.63

GC content: 71.32

Gene sequence:

>1527_bases
ATGAGCATGCTGAACGTGGGCCGCCCCACCCGCCCCGAGGCCGCCGAGCCCGCCCAGACCTCGCTGACCGGCGGCCGCGG
CCTCCTCCAGGACGAGCCGCTGCTGTTCGAGGTGGGCGGCTGGGACAAGACCGGCGTCGACCTGCCGGACGGCCCCGACG
CCGACGACCTGGCGGGCCTGACCCGCGACGGCGTGGATCTGCCGGGCCTTTCCGAGCCCGAGGCCGTGCGCCACTACGTC
CGCCTGTCCCAGAAGAACCACGCCATCGACCTGGCGCTCTATCCGCTGGGCTCGTGCACCATGAAGCACAACCCGCGCCT
GAACGAGAAGATGGCGCGGCTGGCGGGCTTCGCCGACCTGCACCCGCTGCAGCCGGTCTCCACGACCCAGGGCGCGCTGC
AGCTCATGGACCGCCTCGCCCACTGGCTGAAGACCCTGACCGGCATGCCGGCCGTCGCGCTGTCTCCCAAGGCCGGCGCC
CACGGCGAGCTCTGCGGCCTGCTGTGCATCAAGGCGGCCCACGAGGCGGCCGGCCAGGGCCACCGCCGCACCGTGCTGGT
CCCGACCTCGGCGCACGGGACCAACCCGGCCACCGCCGCCTTCGTCGGCTATTCGGTGACCGAGATCGCCCAGACCGACG
ACGGCCGCGTGGACCTTTCCGACCTCGCCGCCAAGCTCGGCCCGGACGTTGCGGCCATCATGGTCACGAACCCCAACACC
TGCGGTCTTTTCGAGCGCGATGTCATTGAAATTGCTCGACTAACTCACGACGCCGGCGCCTATTTCTACTGCGACGGCGC
CAATTTCAACGCCATCGTCGGCAAGGTCCGCCCCGGCGACCTCGGCGTCGACGCCATGCACATCAACCTGCACAAGACCT
TCTCCACCCCGCACGGCGGCGGCGGTCCCGGCGCAGGCCCGGTGGTGCTCTCGCAGGCCCTCGCCCCCTTCGCCCCCGCC
CCCTGGATCGTCAGCGGCCCCGACGCCCTGGGTCTCCAGGAGCAGGACGCCGGCTTCGGCCGCATGTGCGCCTTCCACGG
CCAGATGGGCATGTTCGTCCGCGCCTACGCCTACATGCTCAGCCACGGCGCCGACGGCCTGCGTCAGGTCGCCGAGGACG
CCGTGCTGAACGCCAACTACGTCAAGGCCCGGCTGTCCGACGTCATGAGCCCGGCCTTCCCCGAGGGTCCGTGCATGCAC
GAGGCCCTGTTCGACGACGCCTGGCTGGACGGCACGGGCGTCACCACCCTCGACTTCGCCAAGGCGATGATCGACGAGGG
CTTCCACCCCATGACCATGTACTTCCCGCTGGTCGTCCACGGCGCGATGCTCATCGAGCCGACCGAGACGGAGTCGAAGG
CGGAGCTCGACCGGTTCTGCGAGGCGCTCCGGGCGCTCGCCGGCGCCGCCAAGGCGGGCGAAGCCGAGCGGTTCAAGGGC
GCGCCGTTCCTGGCTCCCCTGCGTCGCCTGGACGAGACCCTCGCGGCGCGGAAGCCGAAGCTCGCCTGGACGCCGCCCGC
CGAGTGA

Upstream 100 bases:

>100_bases
GCCTGGATCCCGGCGCGGGCCTGGACGACGTCCTGCTGCTCTGCGCCACCGAGACCACCACCTCCGACGACATCGCCGCG
CTGAAGGACGCGCTCGCCCG

Downstream 100 bases:

>100_bases
TTGTGGCGGCGCCTCGGCGCATCTGTGACGACTTTGCATCGGAGGGTGTGGCGCCGGCGCCATCAGCCTTGGAATAGGTG
CGGGTTAGGAAAATTTAACG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSMLNVGRPTRPEAAEPAQTSLTGGRGLLQDEPLLFEVGGWDKTGVDLPDGPDADDLAGLTRDGVDLPGLSEPEAVRHYV
RLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLAGFADLHPLQPVSTTQGALQLMDRLAHWLKTLTGMPAVALSPKAGA
HGELCGLLCIKAAHEAAGQGHRRTVLVPTSAHGTNPATAAFVGYSVTEIAQTDDGRVDLSDLAAKLGPDVAAIMVTNPNT
CGLFERDVIEIARLTHDAGAYFYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSQALAPFAPA
PWIVSGPDALGLQEQDAGFGRMCAFHGQMGMFVRAYAYMLSHGADGLRQVAEDAVLNANYVKARLSDVMSPAFPEGPCMH
EALFDDAWLDGTGVTTLDFAKAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKAELDRFCEALRALAGAAKAGEAERFKG
APFLAPLRRLDETLAARKPKLAWTPPAE

Sequences:

>Translated_508_residues
MSMLNVGRPTRPEAAEPAQTSLTGGRGLLQDEPLLFEVGGWDKTGVDLPDGPDADDLAGLTRDGVDLPGLSEPEAVRHYV
RLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLAGFADLHPLQPVSTTQGALQLMDRLAHWLKTLTGMPAVALSPKAGA
HGELCGLLCIKAAHEAAGQGHRRTVLVPTSAHGTNPATAAFVGYSVTEIAQTDDGRVDLSDLAAKLGPDVAAIMVTNPNT
CGLFERDVIEIARLTHDAGAYFYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSQALAPFAPA
PWIVSGPDALGLQEQDAGFGRMCAFHGQMGMFVRAYAYMLSHGADGLRQVAEDAVLNANYVKARLSDVMSPAFPEGPCMH
EALFDDAWLDGTGVTTLDFAKAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKAELDRFCEALRALAGAAKAGEAERFKG
APFLAPLRRLDETLAARKPKLAWTPPAE
>Mature_507_residues
SMLNVGRPTRPEAAEPAQTSLTGGRGLLQDEPLLFEVGGWDKTGVDLPDGPDADDLAGLTRDGVDLPGLSEPEAVRHYVR
LSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLAGFADLHPLQPVSTTQGALQLMDRLAHWLKTLTGMPAVALSPKAGAH
GELCGLLCIKAAHEAAGQGHRRTVLVPTSAHGTNPATAAFVGYSVTEIAQTDDGRVDLSDLAAKLGPDVAAIMVTNPNTC
GLFERDVIEIARLTHDAGAYFYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSQALAPFAPAP
WIVSGPDALGLQEQDAGFGRMCAFHGQMGMFVRAYAYMLSHGADGLRQVAEDAVLNANYVKARLSDVMSPAFPEGPCMHE
ALFDDAWLDGTGVTTLDFAKAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKAELDRFCEALRALAGAAKAGEAERFKGA
PFLAPLRRLDETLAARKPKLAWTPPAE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=425, Percent_Identity=39.0588235294118, Blast_Score=250, Evalue=3e-66,
Organism=Escherichia coli, GI1789269, Length=416, Percent_Identity=43.0288461538462, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=38.3863080684597, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI32564013, Length=383, Percent_Identity=38.1201044386423, Blast_Score=222, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=418, Percent_Identity=38.2775119617225, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24645648, Length=426, Percent_Identity=38.7323943661972, Blast_Score=257, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53946; Mature: 53815

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLNVGRPTRPEAAEPAQTSLTGGRGLLQDEPLLFEVGGWDKTGVDLPDGPDADDLAGL
CCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCC
TRDGVDLPGLSEPEAVRHYVRLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLAGFADL
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCC
HPLQPVSTTQGALQLMDRLAHWLKTLTGMPAVALSPKAGAHGELCGLLCIKAAHEAAGQG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
HRRTVLVPTSAHGTNPATAAFVGYSVTEIAQTDDGRVDLSDLAAKLGPDVAAIMVTNPNT
CCEEEEEECCCCCCCCCHHHHHCCHHHHHHCCCCCCEEHHHHHHHHCCCEEEEEEECCCC
CGLFERDVIEIARLTHDAGAYFYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGG
CCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCC
GGPGAGPVVLSQALAPFAPAPWIVSGPDALGLQEQDAGFGRMCAFHGQMGMFVRAYAYML
CCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHH
SHGADGLRQVAEDAVLNANYVKARLSDVMSPAFPEGPCMHEALFDDAWLDGTGVTTLDFA
HCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHH
KAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKAELDRFCEALRALAGAAKAGEAERFKG
HHHHHCCCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
APFLAPLRRLDETLAARKPKLAWTPPAE
CCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SMLNVGRPTRPEAAEPAQTSLTGGRGLLQDEPLLFEVGGWDKTGVDLPDGPDADDLAGL
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCC
TRDGVDLPGLSEPEAVRHYVRLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLAGFADL
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCC
HPLQPVSTTQGALQLMDRLAHWLKTLTGMPAVALSPKAGAHGELCGLLCIKAAHEAAGQG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
HRRTVLVPTSAHGTNPATAAFVGYSVTEIAQTDDGRVDLSDLAAKLGPDVAAIMVTNPNT
CCEEEEEECCCCCCCCCHHHHHCCHHHHHHCCCCCCEEHHHHHHHHCCCEEEEEEECCCC
CGLFERDVIEIARLTHDAGAYFYCDGANFNAIVGKVRPGDLGVDAMHINLHKTFSTPHGG
CCCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCC
GGPGAGPVVLSQALAPFAPAPWIVSGPDALGLQEQDAGFGRMCAFHGQMGMFVRAYAYML
CCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHH
SHGADGLRQVAEDAVLNANYVKARLSDVMSPAFPEGPCMHEALFDDAWLDGTGVTTLDFA
HCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHH
KAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKAELDRFCEALRALAGAAKAGEAERFKG
HHHHHCCCCCHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
APFLAPLRRLDETLAARKPKLAWTPPAE
CCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]