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The map label for this gene is mutY [H]

Identifier: 197104044

GI number: 197104044

Start: 612961

End: 614010

Strand: Reverse

Name: mutY [H]

Synonym: PHZ_c0578

Alternate gene names: 197104044

Gene position: 614010-612961 (Counterclockwise)

Preceding gene: 197104054

Following gene: 197104039

Centisome position: 15.36

GC content: 75.52

Gene sequence:

>1050_bases
ATGAAGGCCGCCGTGACCCTCCGCGCCCAGCTGCTCGCCTGGTACGACCAGAACGCCCGCGACCTGCCCTGGCGGGTGGG
GCCCGCCGACCGTGCGGCAGGGGTCCGGGCCGATCCCTACCGGGTCTGGCTGTCCGAGGTGATGCTGCAGCAGACGACCG
TGCCGCACGCCACGCCCTACTTCCTGAAGTTCACGGCCCGCTGGCCGACCGTATCCGACCTCGCCGCCGCGCCGGACGAG
GAGGTCATGGCCGCCTGGGCGGGCCTGGGCTACTACGCCCGCGCCCGAAACCTGCTGGCGTGCGCCCGGGCGGTGGCGAA
CGACCACGGCGGCGTCTTCCCGGACACCGAGGCGGGCCTGCTGAAGCTGCCGGGCCTTGGCCCCTACACGGCGGCGGCGG
TCGCGGCGATCGCCTTCGACCGCCCGGCCAATGTGGTGGACGGCAATGTCGAGCGGGTGGTCTCGCGCCTCTTCGCCGTC
GAGCAGCCGCTGCCCGCGGCCAAGCCCGAGCTGAAGCGGCTCGCCGCCGCGCTCGTGGCCGAGGACCGGCCCGGCGACTG
GGCCCAGGCCCTGATGGATCTGGGAGCGACGATCTGCCGCCCCAAGGCGCCGCTGTGCGACCGCTGCCCCCTCGCCGATC
ACTGCGCCGCCTTCGCGACCGGGACGCCGGACGCCTGGCCCCGGAAGACGGCCAAGGCCGCGCGGCCGCGACGCCACGGC
GTGGCCTATGTGCTGACGCGCGGCGACCAGGTGGCCCTGGTGCGCCGCCCGCCCAAGGGGCTGCTGGGCGGCATGCTGGC
CCTGCCCACCAGCGACTGGCGGTCCGAGCCCTGGTCCGAGGCCGAGGCGATCTCGGCCGCCCCCGCGCCGGCCGCCTGGC
GCGGCGTGGGCGAGGTCGAGCACGTCTTCACGCACTTCTCCCTGACGCTGCGGCTCTTGCGCGCGGAGGGCGACGCCGAC
GGCGTGATCTGGAGCCCGCGCGGCGACCTGGAGGCGCTGCCCAGCGTGTTCCTGAAGGCGGCCCGCGCGGGGCTCTCGAA
CCTGCTCTAG

Upstream 100 bases:

>100_bases
ATCCCCGGCCCTTGCGGAAGGCGGTCCCAAGGCGCCGGCCGAATCGACGCAGGCCGCCTGCGCCCCCGATCCCGCTCGCG
CGCGCCGGACCGATGACGGT

Downstream 100 bases:

>100_bases
GCGGGGAGCTGCGAGCGGACCTTGGCGCGCAGCACATCGATGGGGGCGAGGCCCTTGTCCGACTTGAAGTGCCAGTAGGT
CCAGCCGTTGCAGGCCGGCG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKAAVTLRAQLLAWYDQNARDLPWRVGPADRAAGVRADPYRVWLSEVMLQQTTVPHATPYFLKFTARWPTVSDLAAAPDE
EVMAAWAGLGYYARARNLLACARAVANDHGGVFPDTEAGLLKLPGLGPYTAAAVAAIAFDRPANVVDGNVERVVSRLFAV
EQPLPAAKPELKRLAAALVAEDRPGDWAQALMDLGATICRPKAPLCDRCPLADHCAAFATGTPDAWPRKTAKAARPRRHG
VAYVLTRGDQVALVRRPPKGLLGGMLALPTSDWRSEPWSEAEAISAAPAPAAWRGVGEVEHVFTHFSLTLRLLRAEGDAD
GVIWSPRGDLEALPSVFLKAARAGLSNLL

Sequences:

>Translated_349_residues
MKAAVTLRAQLLAWYDQNARDLPWRVGPADRAAGVRADPYRVWLSEVMLQQTTVPHATPYFLKFTARWPTVSDLAAAPDE
EVMAAWAGLGYYARARNLLACARAVANDHGGVFPDTEAGLLKLPGLGPYTAAAVAAIAFDRPANVVDGNVERVVSRLFAV
EQPLPAAKPELKRLAAALVAEDRPGDWAQALMDLGATICRPKAPLCDRCPLADHCAAFATGTPDAWPRKTAKAARPRRHG
VAYVLTRGDQVALVRRPPKGLLGGMLALPTSDWRSEPWSEAEAISAAPAPAAWRGVGEVEHVFTHFSLTLRLLRAEGDAD
GVIWSPRGDLEALPSVFLKAARAGLSNLL
>Mature_349_residues
MKAAVTLRAQLLAWYDQNARDLPWRVGPADRAAGVRADPYRVWLSEVMLQQTTVPHATPYFLKFTARWPTVSDLAAAPDE
EVMAAWAGLGYYARARNLLACARAVANDHGGVFPDTEAGLLKLPGLGPYTAAAVAAIAFDRPANVVDGNVERVVSRLFAV
EQPLPAAKPELKRLAAALVAEDRPGDWAQALMDLGATICRPKAPLCDRCPLADHCAAFATGTPDAWPRKTAKAARPRRHG
VAYVLTRGDQVALVRRPPKGLLGGMLALPTSDWRSEPWSEAEAISAAPAPAAWRGVGEVEHVFTHFSLTLRLLRAEGDAD
GVIWSPRGDLEALPSVFLKAARAGLSNLL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=361, Percent_Identity=37.9501385041551, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI115298654, Length=361, Percent_Identity=37.9501385041551, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI115298652, Length=361, Percent_Identity=37.9501385041551, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI115298650, Length=361, Percent_Identity=37.9501385041551, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI6912520, Length=361, Percent_Identity=37.9501385041551, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI190358497, Length=361, Percent_Identity=37.9501385041551, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1789331, Length=314, Percent_Identity=40.7643312101911, Blast_Score=210, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37538; Mature: 37538

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVTLRAQLLAWYDQNARDLPWRVGPADRAAGVRADPYRVWLSEVMLQQTTVPHATPY
CCCHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
FLKFTARWPTVSDLAAAPDEEVMAAWAGLGYYARARNLLACARAVANDHGGVFPDTEAGL
EEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LKLPGLGPYTAAAVAAIAFDRPANVVDGNVERVVSRLFAVEQPLPAAKPELKRLAAALVA
EECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EDRPGDWAQALMDLGATICRPKAPLCDRCPLADHCAAFATGTPDAWPRKTAKAARPRRHG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
VAYVLTRGDQVALVRRPPKGLLGGMLALPTSDWRSEPWSEAEAISAAPAPAAWRGVGEVE
EEEEEECCCEEEEEECCCHHHHCCCHHCCCCHHCCCCCCHHHHHCCCCCCHHHHCCHHHH
HVFTHFSLTLRLLRAEGDADGVIWSPRGDLEALPSVFLKAARAGLSNLL
HHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAAVTLRAQLLAWYDQNARDLPWRVGPADRAAGVRADPYRVWLSEVMLQQTTVPHATPY
CCCHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
FLKFTARWPTVSDLAAAPDEEVMAAWAGLGYYARARNLLACARAVANDHGGVFPDTEAGL
EEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LKLPGLGPYTAAAVAAIAFDRPANVVDGNVERVVSRLFAVEQPLPAAKPELKRLAAALVA
EECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EDRPGDWAQALMDLGATICRPKAPLCDRCPLADHCAAFATGTPDAWPRKTAKAARPRRHG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
VAYVLTRGDQVALVRRPPKGLLGGMLALPTSDWRSEPWSEAEAISAAPAPAAWRGVGEVE
EEEEEECCCEEEEEECCCHHHHCCCHHCCCCHHCCCCCCHHHHHCCCCCCHHHHCCHHHH
HVFTHFSLTLRLLRAEGDADGVIWSPRGDLEALPSVFLKAARAGLSNLL
HHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]