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The map label for this gene is paxA [H]

Identifier: 197103998

GI number: 197103998

Start: 559149

End: 560498

Strand: Direct

Name: paxA [H]

Synonym: PHZ_c0532

Alternate gene names: 197103998

Gene position: 559149-560498 (Clockwise)

Preceding gene: 197103997

Following gene: 197104001

Centisome position: 13.99

GC content: 71.78

Gene sequence:

>1350_bases
ATGTCCGCGCCGACCCCCTACGAGCAGTACATGCTGGAGCTGGTCAACGCCGAGCGCGCCGCGGCCGGCGTGCAGCCGCT
GGCCTTCGACTTCCTGCTGAACGATTCCGCCGAGCTGCACAGCCAGTGGATGATCGCCAACGACACCTTCAGCCACACCG
GCGCGGGAGGCTCCACGCCGACCGACCGCATGGTGGCGGCGGGCTACCAGCTCACCGGCTCGTGGACGACCGGCGAGAAC
CTCGCCTGGCAGAGCCTGCGCGGCGCGGCCGGGATCCAGGACGACGTGGCCGATCTGCACGTCGGCCTGATGAACTCCCC
CGGCCACCGGGCCAACATCCTGAACGGGAACTTCCGCCAGGTCGGCATCGGCATAGAGACCGGCGAATACCAGGGCTGGC
AGGGCGTATTCGCCACCCAGAACTTCGCCAAGACCGGCAGCGCCTACTTCATCACCGGCGTCGCGTTCGACGACCTGGAC
GGCGACGTCTTCTACGATCCGGGCGAGGGCCTGGGCGGGATCAACGTGACGGTGACCAGCGCCGCGACGGGCCAGGCGGT
GAGCGCCCTCACCTATGGCTCCGGCGGCTACGAGGTGGCGGTCGCGCCCGGGACCTACACCGTCACCTTCTCCGGCGGCG
GCTTCGCCGCGTCCAGCCGCACGGTCTCGGTGGGCTCGGCCAATGTGAAGGTAGACTGGGCCGACCCGCCGCTCGGCGCA
GGCGGCGGCGCGCCCACCCCCGGGAACGACGACCTGACCGGCACGCCGCTGCACGGCGGGGCGGGAAACGACACCCTCAC
CGGAACCTCCGGCGAGAACTATCTGCGCGGCGACGCCGGTGACGACCGCCTGGTCGGCGGGCCGCTGTTCGACGACCTGC
ACGGCAACATCGGGAACGACACCGTCTACGGCGGCGCGGGCGGCGACTGGGTGGTCGGCGGCCAGGGCCACGACCAGCTG
TTCGGCGACGATGGCCACGACGCGGTGCTGGGCAACCTCGGGAACGACGTGCTGCTGGGCGGGACCGGGAACGACGTCAT
GCGCGGGGGCCAGGGCGACGATGCGGTGACCGGCGGCGCGGGCGACGACTGGCTGGCGGGCGACCGCGGCTCGGACACCC
TGGCCGGCGCGCGCGGCGCCGACACCTTCCACAGCTTCGCCGGGGCCGGCCTCGACCACATCCTGGACTTCAACTTCGCC
GAGGGCGACCGCCTCAACCTCGTGGCCGGCTCCGGCTACAACGCCTACCAGTCGGGCGCCGACGTGATCGTCGACGTCGC
GGACGGCCGGATCGTCCTGGCGGGCGTGTCCATGTCCAGCCTGGGGGAGGGCTGGATCTACCTGGGCTGA

Upstream 100 bases:

>100_bases
GAAGACCGCCGTCTGGGCCCTGCCGGAAGCGCGGCCCTAGGCCCCTTTTTCGCCGCGCCCGCGTTGAACCCTGGAAAGGT
TCAACTTTTCCGAGGTCCCG

Downstream 100 bases:

>100_bases
CCGATCGCGTCCTCCAGCGCGGCGGCGAGGTCGCCGCGGCGGGCGACGCGGACGCGCCCCAGTCCCAGCCAGGCCGCCAT
CGTCCCCAGCTCCTCGGCGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSAPTPYEQYMLELVNAERAAAGVQPLAFDFLLNDSAELHSQWMIANDTFSHTGAGGSTPTDRMVAAGYQLTGSWTTGEN
LAWQSLRGAAGIQDDVADLHVGLMNSPGHRANILNGNFRQVGIGIETGEYQGWQGVFATQNFAKTGSAYFITGVAFDDLD
GDVFYDPGEGLGGINVTVTSAATGQAVSALTYGSGGYEVAVAPGTYTVTFSGGGFAASSRTVSVGSANVKVDWADPPLGA
GGGAPTPGNDDLTGTPLHGGAGNDTLTGTSGENYLRGDAGDDRLVGGPLFDDLHGNIGNDTVYGGAGGDWVVGGQGHDQL
FGDDGHDAVLGNLGNDVLLGGTGNDVMRGGQGDDAVTGGAGDDWLAGDRGSDTLAGARGADTFHSFAGAGLDHILDFNFA
EGDRLNLVAGSGYNAYQSGADVIVDVADGRIVLAGVSMSSLGEGWIYLG

Sequences:

>Translated_449_residues
MSAPTPYEQYMLELVNAERAAAGVQPLAFDFLLNDSAELHSQWMIANDTFSHTGAGGSTPTDRMVAAGYQLTGSWTTGEN
LAWQSLRGAAGIQDDVADLHVGLMNSPGHRANILNGNFRQVGIGIETGEYQGWQGVFATQNFAKTGSAYFITGVAFDDLD
GDVFYDPGEGLGGINVTVTSAATGQAVSALTYGSGGYEVAVAPGTYTVTFSGGGFAASSRTVSVGSANVKVDWADPPLGA
GGGAPTPGNDDLTGTPLHGGAGNDTLTGTSGENYLRGDAGDDRLVGGPLFDDLHGNIGNDTVYGGAGGDWVVGGQGHDQL
FGDDGHDAVLGNLGNDVLLGGTGNDVMRGGQGDDAVTGGAGDDWLAGDRGSDTLAGARGADTFHSFAGAGLDHILDFNFA
EGDRLNLVAGSGYNAYQSGADVIVDVADGRIVLAGVSMSSLGEGWIYLG
>Mature_448_residues
SAPTPYEQYMLELVNAERAAAGVQPLAFDFLLNDSAELHSQWMIANDTFSHTGAGGSTPTDRMVAAGYQLTGSWTTGENL
AWQSLRGAAGIQDDVADLHVGLMNSPGHRANILNGNFRQVGIGIETGEYQGWQGVFATQNFAKTGSAYFITGVAFDDLDG
DVFYDPGEGLGGINVTVTSAATGQAVSALTYGSGGYEVAVAPGTYTVTFSGGGFAASSRTVSVGSANVKVDWADPPLGAG
GGAPTPGNDDLTGTPLHGGAGNDTLTGTSGENYLRGDAGDDRLVGGPLFDDLHGNIGNDTVYGGAGGDWVVGGQGHDQLF
GDDGHDAVLGNLGNDVLLGGTGNDVMRGGQGDDAVTGGAGDDWLAGDRGSDTLAGARGADTFHSFAGAGLDHILDFNFAE
GDRLNLVAGSGYNAYQSGADVIVDVADGRIVLAGVSMSSLGEGWIYLG

Specific function: PaxA is associated with abortion cases in swine and septicemia in young piglets. Shows cohemolytic activity with the sphingomyelinase of S.aureus but is devoid of direct hemolytic activity [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 6 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR013550
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX; PF08339 RTX_C [H]

EC number: NA

Molecular weight: Translated: 45595; Mature: 45464

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTPYEQYMLELVNAERAAAGVQPLAFDFLLNDSAELHSQWMIANDTFSHTGAGGSTP
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCEEEEECCCCCCCCCCCCCC
TDRMVAAGYQLTGSWTTGENLAWQSLRGAAGIQDDVADLHVGLMNSPGHRANILNGNFRQ
CCCEEECCEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHEEEEECCCCCEEEEECCCCEE
VGIGIETGEYQGWQGVFATQNFAKTGSAYFITGVAFDDLDGDVFYDPGEGLGGINVTVTS
EEEEEECCCCCCCCEEEEECCHHHCCCEEEEEEEEEECCCCCEEECCCCCCCCEEEEEEC
AATGQAVSALTYGSGGYEVAVAPGTYTVTFSGGGFAASSRTVSVGSANVKVDWADPPLGA
CCCCCEEEEEEECCCCEEEEECCCEEEEEECCCCEECCCCEEEECCCEEEEEECCCCCCC
GGGAPTPGNDDLTGTPLHGGAGNDTLTGTSGENYLRGDAGDDRLVGGPLFDDLHGNIGND
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCCCEECCCCHHHHCCCCCCC
TVYGGAGGDWVVGGQGHDQLFGDDGHDAVLGNLGNDVLLGGTGNDVMRGGQGDDAVTGGA
EEECCCCCCEEECCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCCEECCC
GDDWLAGDRGSDTLAGARGADTFHSFAGAGLDHILDFNFAEGDRLNLVAGSGYNAYQSGA
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHEECCCCCCCEEEEEECCCCCHHCCCC
DVIVDVADGRIVLAGVSMSSLGEGWIYLG
CEEEEECCCEEEEEECCHHHCCCCEEEEC
>Mature Secondary Structure 
SAPTPYEQYMLELVNAERAAAGVQPLAFDFLLNDSAELHSQWMIANDTFSHTGAGGSTP
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCEEEEECCCCCCCCCCCCCC
TDRMVAAGYQLTGSWTTGENLAWQSLRGAAGIQDDVADLHVGLMNSPGHRANILNGNFRQ
CCCEEECCEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHEEEEECCCCCEEEEECCCCEE
VGIGIETGEYQGWQGVFATQNFAKTGSAYFITGVAFDDLDGDVFYDPGEGLGGINVTVTS
EEEEEECCCCCCCCEEEEECCHHHCCCEEEEEEEEEECCCCCEEECCCCCCCCEEEEEEC
AATGQAVSALTYGSGGYEVAVAPGTYTVTFSGGGFAASSRTVSVGSANVKVDWADPPLGA
CCCCCEEEEEEECCCCEEEEECCCEEEEEECCCCEECCCCEEEECCCEEEEEECCCCCCC
GGGAPTPGNDDLTGTPLHGGAGNDTLTGTSGENYLRGDAGDDRLVGGPLFDDLHGNIGND
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCCCEECCCCHHHHCCCCCCC
TVYGGAGGDWVVGGQGHDQLFGDDGHDAVLGNLGNDVLLGGTGNDVMRGGQGDDAVTGGA
EEECCCCCCEEECCCCCCCCCCCCCCCEEEECCCCEEEECCCCHHHHCCCCCCCCEECCC
GDDWLAGDRGSDTLAGARGADTFHSFAGAGLDHILDFNFAEGDRLNLVAGSGYNAYQSGA
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHEECCCCCCCEEEEEECCCCCHHCCCC
DVIVDVADGRIVLAGVSMSSLGEGWIYLG
CEEEEECCCEEEEEECCHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10603361 [H]