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The map label for this gene is phbA [H]

Identifier: 197103897

GI number: 197103897

Start: 438643

End: 439818

Strand: Direct

Name: phbA [H]

Synonym: PHZ_c0431

Alternate gene names: 197103897

Gene position: 438643-439818 (Clockwise)

Preceding gene: 197103894

Following gene: 197103898

Centisome position: 10.98

GC content: 71.17

Gene sequence:

>1176_bases
ATGAGCGACATCGTCATCGTTTCCGCCGCCCGCACGCCCGTGGGCTCGTTCAACGGCGCCCTTTCGAGCCTGCCGGCCCA
TGAGCTGGGCAAGCTGGCGATCCAGGCGGCGGTGGAGCGGGCCGGCATCCAGGCCGCCGACGTGGACGAGGTGATCCTCG
GCCAGGTGCTGCAGGCGGGCCAGGGCCAGGGCCCGGCGCGGCAGGCGGCGGTGGGCGCGGGCGTGCCGGTGGAGAGCCCG
GCGTGGAGCCTGAACCAGCTCTGCGGCTCGGGCCTGCGCGCGGTGGCGCTGGCGGCCCAGCAGATCCAGGACGGCTCGTC
GAAGATCGTCGTGGCCGGCGGCCAGGAGAGCATGAGCCAGTCGCCGCACGCGGCGAACCTGCGGGCCGGCCAGAAGATGG
GCGAGCTGGCCCTCGTCGACACCATGCTGAAGGACGGCCTGTGGGACGCCTTCCACGGCTACCACATGGGCCAGACGGCC
GAGAACATCGCCGGCCGCTGGCAGATCACCCGCGAGGACCAGGACCGGTTCGCGGTGGTCTCGCAGAACCGCGCCGAGGC
GGCCCAGAAGGCCGGCAAGTTCAAGGACGAGATCGTCCCCGTGACCATCAAGGGCCGCAAGGGCGACACGGTCGTCAGCG
AGGACGAATACATCCGCCACGGGGTGACGTTGGACAGCGTCTCGGGCCTGCGGCCGGCCTTCACCAAGGACGGCTCGGTG
ACCGCGGCCAACGCCTCGGGAATCAACGACGGCGCGGCGGCCCTGGTGCTGATGAGCGCCGACGAAGCCGCCCGACGCGG
CCTGAAGCCCCTGGCGCGGATCGCCTCCTGGGCCCACGCGGGCGTCGATCCCGAGATCATGGGCACTGGCCCGATCCCGG
CCAGCACCAAGGCGCTGGAGAAGGCCGGCTGGAAGGTGGCCGACCTCGACCTGGTGGAATCCAACGAGGCGTTCGCCGCC
CAATCGCTGTGCGTCGTGCGCGAACTGGGCCTCGACCCGGAAAAGGTCAATGTGAACGGCGGGGCGATCGCTATCGGTCA
TCCCATCGGCGCCTCGGGCGCGCGGATCCTTACCACCCTGCTGCACGAGATGAAGCGGTCGGGGAAGGCGAAGGGCCTGG
CGACCCTGTGCGTCGGCGGCGGCATGGGCGTGGCCATGTGCGTCGAGACGGTGTGA

Upstream 100 bases:

>100_bases
CCGAAAGGATTCACAAGCCCGGGGTTGCGGGCCGGCTTCGCCTTGCCGATAGAAGGAGCGGGCCGCACATCACCAGTCAG
GAGCCCTCCGGGAGCCCCCC

Downstream 100 bases:

>100_bases
GCGGGAAAGGCCGGCGCCTGAGGCCGGCCGCCGCCGACTAGGGAGGTGTGGAATGGCCCGTGTGGCTCTCGTGACCGGCG
GCACGCGCGGCATCGGCCGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSDIVIVSAARTPVGSFNGALSSLPAHELGKLAIQAAVERAGIQAADVDEVILGQVLQAGQGQGPARQAAVGAGVPVESP
AWSLNQLCGSGLRAVALAAQQIQDGSSKIVVAGGQESMSQSPHAANLRAGQKMGELALVDTMLKDGLWDAFHGYHMGQTA
ENIAGRWQITREDQDRFAVVSQNRAEAAQKAGKFKDEIVPVTIKGRKGDTVVSEDEYIRHGVTLDSVSGLRPAFTKDGSV
TAANASGINDGAAALVLMSADEAARRGLKPLARIASWAHAGVDPEIMGTGPIPASTKALEKAGWKVADLDLVESNEAFAA
QSLCVVRELGLDPEKVNVNGGAIAIGHPIGASGARILTTLLHEMKRSGKAKGLATLCVGGGMGVAMCVETV

Sequences:

>Translated_391_residues
MSDIVIVSAARTPVGSFNGALSSLPAHELGKLAIQAAVERAGIQAADVDEVILGQVLQAGQGQGPARQAAVGAGVPVESP
AWSLNQLCGSGLRAVALAAQQIQDGSSKIVVAGGQESMSQSPHAANLRAGQKMGELALVDTMLKDGLWDAFHGYHMGQTA
ENIAGRWQITREDQDRFAVVSQNRAEAAQKAGKFKDEIVPVTIKGRKGDTVVSEDEYIRHGVTLDSVSGLRPAFTKDGSV
TAANASGINDGAAALVLMSADEAARRGLKPLARIASWAHAGVDPEIMGTGPIPASTKALEKAGWKVADLDLVESNEAFAA
QSLCVVRELGLDPEKVNVNGGAIAIGHPIGASGARILTTLLHEMKRSGKAKGLATLCVGGGMGVAMCVETV
>Mature_390_residues
SDIVIVSAARTPVGSFNGALSSLPAHELGKLAIQAAVERAGIQAADVDEVILGQVLQAGQGQGPARQAAVGAGVPVESPA
WSLNQLCGSGLRAVALAAQQIQDGSSKIVVAGGQESMSQSPHAANLRAGQKMGELALVDTMLKDGLWDAFHGYHMGQTAE
NIAGRWQITREDQDRFAVVSQNRAEAAQKAGKFKDEIVPVTIKGRKGDTVVSEDEYIRHGVTLDSVSGLRPAFTKDGSVT
AANASGINDGAAALVLMSADEAARRGLKPLARIASWAHAGVDPEIMGTGPIPASTKALEKAGWKVADLDLVESNEAFAAQ
SLCVVRELGLDPEKVNVNGGAIAIGHPIGASGARILTTLLHEMKRSGKAKGLATLCVGGGMGVAMCVETV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=60.3092783505155, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=46.3104325699746, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=43.2569974554707, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=41.5189873417722, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=32, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=31.2020460358056, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788554, Length=391, Percent_Identity=56.5217391304348, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=53.3333333333333, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=43.640897755611, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=42.6799007444169, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=35.781990521327, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=47.1794871794872, Blast_Score=340, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=44.8186528497409, Blast_Score=323, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=39.1857506361323, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=34.8484848484849, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=33.1764705882353, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=45.4545454545455, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=39.0745501285347, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=59.3830334190231, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=45.8015267175573, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=43.5114503816794, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=32.1513002364066, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40270; Mature: 40139

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVIVSAARTPVGSFNGALSSLPAHELGKLAIQAAVERAGIQAADVDEVILGQVLQAG
CCCEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
QGQGPARQAAVGAGVPVESPAWSLNQLCGSGLRAVALAAQQIQDGSSKIVVAGGQESMSQ
CCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHCC
SPHAANLRAGQKMGELALVDTMLKDGLWDAFHGYHMGQTAENIAGRWQITREDQDRFAVV
CCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHCCCEEEECCCCCCEEEE
SQNRAEAAQKAGKFKDEIVPVTIKGRKGDTVVSEDEYIRHGVTLDSVSGLRPAFTKDGSV
ECCHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCHHHHCCCCHHHCCCCCCCCCCCCCE
TAANASGINDGAAALVLMSADEAARRGLKPLARIASWAHAGVDPEIMGTGPIPASTKALE
EECCCCCCCCCCEEEEEEECCHHHHHCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHH
KAGWKVADLDLVESNEAFAAQSLCVVRELGLDPEKVNVNGGAIAIGHPIGASGARILTTL
HCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHH
LHEMKRSGKAKGLATLCVGGGMGVAMCVETV
HHHHHHCCCCCCEEEEEECCCCCHHHHEECC
>Mature Secondary Structure 
SDIVIVSAARTPVGSFNGALSSLPAHELGKLAIQAAVERAGIQAADVDEVILGQVLQAG
CCEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
QGQGPARQAAVGAGVPVESPAWSLNQLCGSGLRAVALAAQQIQDGSSKIVVAGGQESMSQ
CCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCHHHHCC
SPHAANLRAGQKMGELALVDTMLKDGLWDAFHGYHMGQTAENIAGRWQITREDQDRFAVV
CCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHCCCEEEECCCCCCEEEE
SQNRAEAAQKAGKFKDEIVPVTIKGRKGDTVVSEDEYIRHGVTLDSVSGLRPAFTKDGSV
ECCHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCHHHHCCCCHHHCCCCCCCCCCCCCE
TAANASGINDGAAALVLMSADEAARRGLKPLARIASWAHAGVDPEIMGTGPIPASTKALE
EECCCCCCCCCCEEEEEEECCHHHHHCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHH
KAGWKVADLDLVESNEAFAAQSLCVVRELGLDPEKVNVNGGAIAIGHPIGASGARILTTL
HCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHH
LHEMKRSGKAKGLATLCVGGGMGVAMCVETV
HHHHHHCCCCCCEEEEEECCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]