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The map label for this gene is gcdH [H]

Identifier: 197103757

GI number: 197103757

Start: 285950

End: 287137

Strand: Reverse

Name: gcdH [H]

Synonym: PHZ_c0291

Alternate gene names: 197103757

Gene position: 287137-285950 (Counterclockwise)

Preceding gene: 197103758

Following gene: 197103756

Centisome position: 7.19

GC content: 68.94

Gene sequence:

>1188_bases
ATGCCGCTCGATACAGCCCCGCAAAAGACGTTCCGCTGGGACGACCCGCTGGACCTGTCCTCGCGCCTCTCCGAGGAGGA
GCGCATGGTGTGGGAGGCGGCCCGCCAGTACGCCCGCGAGAAGCTGTTGCCGCGGGTGGTTTCGGCCTACGCCGAAGAGC
GGTTCGACCGCGAGATCATGACCGAGATGGGCGAGCTGGGCTTCCTCGGCCCGACGCTGCCCGAGGAGTACGGCTGCGCG
GGCGTGAACCACGTGGCCTACGGCCTGATCGCCCGCGAGATCGAGGCGATCGATTCCGGCTACCGCTCGGCCATGAGCGT
GCAGTCCTCGCTGGTCATGTACCCGATCTACGCCTTCGGCTCGGAAGACCAGAAGCGCAGGTTCCTGCCCGGCATGGCGG
CGGGGACGATCGTCGGCTGCTTCGGCCTCACCGAGCCGGACGGCGGCTCCGATCCCGCCTCGATGCGCACCACCGCCCGA
AAGGTCGACGGTGGGTATGTGCTGAACGGCGCGAAGATGTGGATCACCAACTCCCCGATCAGCGACGTGGCCCTCGTCTG
GGCCAAGCTGGACGGCAAGATCCGCGGCTTCCTGGTCGAGCGGGGGACCGAGGGCTTCGAGACGCCCCAGATCAAGAACA
AGCTGTCCCTGCGCGCCTCGGTGACCGGCGAGATCGCCCTCTCCGACGCCTTCGTCCCCGAGGACATGATGCTGCCGGGC
GTCGAGGGCCTGCGCGGGCCGTTCTCGTGCCTGAACAAGGCGCGCTACGGCATCGCCTGGGGGGCCATGGGCGCCGCCGA
GTTCTGCCTGCACGCCAGCCGCGACTACGTCTCCAGCCGCAGCCTGTTCGGCCGCACCCTGGCCTCGCGCCAGCTGGTGC
AGAAGAAGCTGGCCGACATGCAGACCGAGATCGCCCTGGGCTTCGAGGGCGCCCTGGCGCTGGGCCGGCTGATCGACGAG
GGCGCCTGGGTGCCCGAGGCCATCTCGATGCTGAAGCGCAACAACTGCGGCAAGGCGCTCGACATCGCCCGCGTCGCCCG
CGACATGCACGGCGGCAACGGCATTTCGGGCGAGTACCACGTGATGCGCCACGCCTCGAACCTCGAGACGGTGAACACCT
ACGAGGGCGCCCATGACGTGCACGCGCTGATCCTGGGTCGGGCCATCACCGGCGAGAGCGCGTTCTAG

Upstream 100 bases:

>100_bases
CTATCACAACCTGCTGCGGATGTGGGCCGAGGTCTGACGCGGGCTACCGTCGGCGACGAAAAGCCGGTATGCCGCGCGCC
TCTGCCCGAAGGAGCCCGCC

Downstream 100 bases:

>100_bases
CCCGGGCCAGGGCGGCCCGCGCAGATTGGCCGCAGGCCCTCCACAACTTTGCGTTTACCCCCACAGTGTAAGCGTGCCCC
GCTTTCGTGGGGGAAACCTT

Product: glutaryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MPLDTAPQKTFRWDDPLDLSSRLSEEERMVWEAARQYAREKLLPRVVSAYAEERFDREIMTEMGELGFLGPTLPEEYGCA
GVNHVAYGLIAREIEAIDSGYRSAMSVQSSLVMYPIYAFGSEDQKRRFLPGMAAGTIVGCFGLTEPDGGSDPASMRTTAR
KVDGGYVLNGAKMWITNSPISDVALVWAKLDGKIRGFLVERGTEGFETPQIKNKLSLRASVTGEIALSDAFVPEDMMLPG
VEGLRGPFSCLNKARYGIAWGAMGAAEFCLHASRDYVSSRSLFGRTLASRQLVQKKLADMQTEIALGFEGALALGRLIDE
GAWVPEAISMLKRNNCGKALDIARVARDMHGGNGISGEYHVMRHASNLETVNTYEGAHDVHALILGRAITGESAF

Sequences:

>Translated_395_residues
MPLDTAPQKTFRWDDPLDLSSRLSEEERMVWEAARQYAREKLLPRVVSAYAEERFDREIMTEMGELGFLGPTLPEEYGCA
GVNHVAYGLIAREIEAIDSGYRSAMSVQSSLVMYPIYAFGSEDQKRRFLPGMAAGTIVGCFGLTEPDGGSDPASMRTTAR
KVDGGYVLNGAKMWITNSPISDVALVWAKLDGKIRGFLVERGTEGFETPQIKNKLSLRASVTGEIALSDAFVPEDMMLPG
VEGLRGPFSCLNKARYGIAWGAMGAAEFCLHASRDYVSSRSLFGRTLASRQLVQKKLADMQTEIALGFEGALALGRLIDE
GAWVPEAISMLKRNNCGKALDIARVARDMHGGNGISGEYHVMRHASNLETVNTYEGAHDVHALILGRAITGESAF
>Mature_394_residues
PLDTAPQKTFRWDDPLDLSSRLSEEERMVWEAARQYAREKLLPRVVSAYAEERFDREIMTEMGELGFLGPTLPEEYGCAG
VNHVAYGLIAREIEAIDSGYRSAMSVQSSLVMYPIYAFGSEDQKRRFLPGMAAGTIVGCFGLTEPDGGSDPASMRTTARK
VDGGYVLNGAKMWITNSPISDVALVWAKLDGKIRGFLVERGTEGFETPQIKNKLSLRASVTGEIALSDAFVPEDMMLPGV
EGLRGPFSCLNKARYGIAWGAMGAAEFCLHASRDYVSSRSLFGRTLASRQLVQKKLADMQTEIALGFEGALALGRLIDEG
AWVPEAISMLKRNNCGKALDIARVARDMHGGNGISGEYHVMRHASNLETVNTYEGAHDVHALILGRAITGESAF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=60.3535353535353, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=59.3085106382979, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=33.1564986737401, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI226958412, Length=386, Percent_Identity=29.7927461139896, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=29.9450549450549, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=27.9255319148936, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=27.9373368146214, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI7656849, Length=392, Percent_Identity=27.8061224489796, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557231, Length=389, Percent_Identity=27.7634961439589, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI187960098, Length=389, Percent_Identity=27.7634961439589, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=29.3963254593176, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI76496475, Length=399, Percent_Identity=29.0726817042606, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=27.1186440677966, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI38505218, Length=332, Percent_Identity=23.4939759036145, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=284, Percent_Identity=25, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082384, Length=286, Percent_Identity=26.5734265734266, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081958, Length=392, Percent_Identity=23.469387755102, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=58.5051546391753, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=29.8941798941799, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=28.4974093264249, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17508101, Length=393, Percent_Identity=27.2264631043257, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985184, Length=396, Percent_Identity=29.2929292929293, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=28.3464566929134, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=30.2325581395349, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71990804, Length=246, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=26.9633507853403, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=25.5208333333333, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17570075, Length=365, Percent_Identity=28.2191780821918, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=28.2051282051282, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=247, Percent_Identity=28.3400809716599, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=267, Percent_Identity=29.5880149812734, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=266, Percent_Identity=28.1954887218045, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=259, Percent_Identity=26.2548262548263, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19920834, Length=395, Percent_Identity=59.746835443038, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21356377, Length=385, Percent_Identity=30.6493506493506, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=28.7234042553192, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=29.1005291005291, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=29.6103896103896, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=28.7958115183246, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281363737, Length=362, Percent_Identity=27.9005524861878, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43160; Mature: 43029

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDTAPQKTFRWDDPLDLSSRLSEEERMVWEAARQYAREKLLPRVVSAYAEERFDREIM
CCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEMGELGFLGPTLPEEYGCAGVNHVAYGLIAREIEAIDSGYRSAMSVQSSLVMYPIYAFG
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHEECC
SEDQKRRFLPGMAAGTIVGCFGLTEPDGGSDPASMRTTARKVDGGYVLNGAKMWITNSPI
CCCHHHHHCCCCHHHHHHEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCEEEEEECCCH
SDVALVWAKLDGKIRGFLVERGTEGFETPQIKNKLSLRASVTGEIALSDAFVPEDMMLPG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHEEEEECCCEEEECCCCCCCCCCCCC
VEGLRGPFSCLNKARYGIAWGAMGAAEFCLHASRDYVSSRSLFGRTLASRQLVQKKLADM
CHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTEIALGFEGALALGRLIDEGAWVPEAISMLKRNNCGKALDIARVARDMHGGNGISGEYH
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHH
VMRHASNLETVNTYEGAHDVHALILGRAITGESAF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLDTAPQKTFRWDDPLDLSSRLSEEERMVWEAARQYAREKLLPRVVSAYAEERFDREIM
CCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEMGELGFLGPTLPEEYGCAGVNHVAYGLIAREIEAIDSGYRSAMSVQSSLVMYPIYAFG
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHEECC
SEDQKRRFLPGMAAGTIVGCFGLTEPDGGSDPASMRTTARKVDGGYVLNGAKMWITNSPI
CCCHHHHHCCCCHHHHHHEECCCCCCCCCCCCHHHHHHHHHCCCCEEECCEEEEEECCCH
SDVALVWAKLDGKIRGFLVERGTEGFETPQIKNKLSLRASVTGEIALSDAFVPEDMMLPG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHEEEEECCCEEEECCCCCCCCCCCCC
VEGLRGPFSCLNKARYGIAWGAMGAAEFCLHASRDYVSSRSLFGRTLASRQLVQKKLADM
CHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTEIALGFEGALALGRLIDEGAWVPEAISMLKRNNCGKALDIARVARDMHGGNGISGEYH
HHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCHH
VMRHASNLETVNTYEGAHDVHALILGRAITGESAF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]