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The map label for this gene is proA [H]

Identifier: 197103718

GI number: 197103718

Start: 251725

End: 253284

Strand: Reverse

Name: proA [H]

Synonym: PHZ_c0252

Alternate gene names: 197103718

Gene position: 253284-251725 (Counterclockwise)

Preceding gene: 197103719

Following gene: 197103717

Centisome position: 6.34

GC content: 77.24

Gene sequence:

>1560_bases
ATGGTGGACGACGGCGGAACATCGAGGCGGACGGCGGGCCGGCTGGAGTCCCTCACTCCCGGCCAGGCGATCCCGTTCGG
CGGCGACCGCGTCGCGCATGTGAGCCCGCAGCTCGCCGCCGCGTTCAGGGCCGGCGACCGGCTGCTGGTCGTGCAGGACA
GCGGCGACCTGCTGCACGTGCCCGCCGCCGAGCAGGCCACGGCCGCGGGCGCCGTGGGCCGGGCCGCCGCCGCCTTCGCG
CGCATGGGCGAGGTCCCGGACGCCGCCGTCACCGCCTTCTTCGAGGCCTTCGCCGCCCGTCTCGCCGACGACGCCGTCTG
GGCCGCGATCGCCGGGGCCAACGCCCGCGACGTCGAGCAGGCCCGGGCCCGCGGCCGCTCCACCACCAGGCTGGCCGTCT
CGGACGCCATGCGCCGGGACATGATCGAGGGCCTGCGCGCCTGGGCCGGCGCCGAGGCCGCCCGCGGCCGGGTGCTGGAG
CGCGTCGAGCACCCCGGCTGGACCGTCGAGCAGGTGGTCGCGCCCCTGGGCGTGGTGGGCTTCGTCTTCGAGGGCCGGCC
GAACGTCTTCGCCGACGCCACCGGCGTGATCCGGGCGGGCAACACCGTGGTCTTCCGCATCGGCTCGGACGCGCTCGGCA
CCGCTCGCGCCATCGTGGCCGAGGCGCTGGACCCGGCGATCACCGAGGCGGGCCTGCCCGAGGGCTGCGCCGCGCTGGTG
GACTCCCCCGCCCACGCCGCCGGCTGGGCCATGTTCGCCGACCCGCGCCTGTCGCTGGCCGTGGCCCGCGGCTCGGGCGC
GGCGGTGGCCCAGCTGGGCGCCATCGCCCGCCAGGCCGGAACGCCCGTCAGCCTTCACGGCACGGGCGGGGCCTGGATGG
TGGCCGACGCCGCCGCCGACGCCGACCGCTTCTTCGCCGCCGCCTACCACTCGCTGGACCGCAAGGTCTGCAACACGCTC
AACACCTGCTGCATCGTCGAGGCCCGCGCCGACGAGCTGGTCCCCGTCTTCCTCGAGGCCCTGCGGAAGGCCGGCGAGCG
CCGCCGGGGCTGCAAGCTGCACGTGGCCGAGCAGGACCTGTCCCGCCTGCCCGAGGCCTGGCGCGCCGGCCGCGGCGTGG
TCGTCCGCGCCGAGGGCCCGCGCGAGGAGCCGCTGGTCGAGCCGCTCGCCGACGCCGAGCTCGGCCGCGAGTGGGAGTGG
GAGGAGACCCCCGAGGTCAGCCTGAGGATCGTCGCCGACCTGGCCGAGGCCGCGGCCCTCTTCAACGCTCACAGCCCGCG
CTTCGTCGCCGCCCTGATCAGCGAGGACCCCGCCGCGCACGCCCGCTTCTTCGCCGCGGTGGACGCCCCGTTCGTGGGCG
ACGGCTTCACCCGCTGGGTGGACGGCCAGTACGCGCTGAAGAAGCCCGAGCTCGGCCTGTCCAACTGGGAGAACGGGCGC
CTGTTCGCCCGCGGCGGCGTGCTGGCCGGCGACGGCGTGTTCTCCGTGCGCACGCGCGTGACCCAGGCCGACCCGCACCT
CGACCGCGGGGGCGCGCCGACCCCGCCGCGCGGGAGCTGA

Upstream 100 bases:

>100_bases
GAGGCCTGAGCGCCGCGTCATCTACGACGCCCGGCGGAAGGCCATTTGCTGACCCCGGGAAAGACGCCTAGGAAGTGCTC
ACCTTGAGCAAATGGGGCCC

Downstream 100 bases:

>100_bases
CCCCTGGCCATGTGGTTCGCAGGTCCGGCCCGCCGGGCGCCCGCCGCCGGCCGGCCGAGGGCGCTGAAGCTCGGCTTCGA
GCTGGAGCACGGCATGCGCG

Product: probable gamma-glutamyl phosphate reductase protein

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MVDDGGTSRRTAGRLESLTPGQAIPFGGDRVAHVSPQLAAAFRAGDRLLVVQDSGDLLHVPAAEQATAAGAVGRAAAAFA
RMGEVPDAAVTAFFEAFAARLADDAVWAAIAGANARDVEQARARGRSTTRLAVSDAMRRDMIEGLRAWAGAEAARGRVLE
RVEHPGWTVEQVVAPLGVVGFVFEGRPNVFADATGVIRAGNTVVFRIGSDALGTARAIVAEALDPAITEAGLPEGCAALV
DSPAHAAGWAMFADPRLSLAVARGSGAAVAQLGAIARQAGTPVSLHGTGGAWMVADAAADADRFFAAAYHSLDRKVCNTL
NTCCIVEARADELVPVFLEALRKAGERRRGCKLHVAEQDLSRLPEAWRAGRGVVVRAEGPREEPLVEPLADAELGREWEW
EETPEVSLRIVADLAEAAALFNAHSPRFVAALISEDPAAHARFFAAVDAPFVGDGFTRWVDGQYALKKPELGLSNWENGR
LFARGGVLAGDGVFSVRTRVTQADPHLDRGGAPTPPRGS

Sequences:

>Translated_519_residues
MVDDGGTSRRTAGRLESLTPGQAIPFGGDRVAHVSPQLAAAFRAGDRLLVVQDSGDLLHVPAAEQATAAGAVGRAAAAFA
RMGEVPDAAVTAFFEAFAARLADDAVWAAIAGANARDVEQARARGRSTTRLAVSDAMRRDMIEGLRAWAGAEAARGRVLE
RVEHPGWTVEQVVAPLGVVGFVFEGRPNVFADATGVIRAGNTVVFRIGSDALGTARAIVAEALDPAITEAGLPEGCAALV
DSPAHAAGWAMFADPRLSLAVARGSGAAVAQLGAIARQAGTPVSLHGTGGAWMVADAAADADRFFAAAYHSLDRKVCNTL
NTCCIVEARADELVPVFLEALRKAGERRRGCKLHVAEQDLSRLPEAWRAGRGVVVRAEGPREEPLVEPLADAELGREWEW
EETPEVSLRIVADLAEAAALFNAHSPRFVAALISEDPAAHARFFAAVDAPFVGDGFTRWVDGQYALKKPELGLSNWENGR
LFARGGVLAGDGVFSVRTRVTQADPHLDRGGAPTPPRGS
>Mature_519_residues
MVDDGGTSRRTAGRLESLTPGQAIPFGGDRVAHVSPQLAAAFRAGDRLLVVQDSGDLLHVPAAEQATAAGAVGRAAAAFA
RMGEVPDAAVTAFFEAFAARLADDAVWAAIAGANARDVEQARARGRSTTRLAVSDAMRRDMIEGLRAWAGAEAARGRVLE
RVEHPGWTVEQVVAPLGVVGFVFEGRPNVFADATGVIRAGNTVVFRIGSDALGTARAIVAEALDPAITEAGLPEGCAALV
DSPAHAAGWAMFADPRLSLAVARGSGAAVAQLGAIARQAGTPVSLHGTGGAWMVADAAADADRFFAAAYHSLDRKVCNTL
NTCCIVEARADELVPVFLEALRKAGERRRGCKLHVAEQDLSRLPEAWRAGRGVVVRAEGPREEPLVEPLADAELGREWEW
EETPEVSLRIVADLAEAAALFNAHSPRFVAALISEDPAAHARFFAAVDAPFVGDGFTRWVDGQYALKKPELGLSNWENGR
LFARGGVLAGDGVFSVRTRVTQADPHLDRGGAPTPPRGS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786438, Length=386, Percent_Identity=27.720207253886, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324899, Length=419, Percent_Identity=26.9689737470167, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 54465; Mature: 54465

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDDGGTSRRTAGRLESLTPGQAIPFGGDRVAHVSPQLAAAFRAGDRLLVVQDSGDLLHV
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEEECCCCEEEC
PAAEQATAAGAVGRAAAAFARMGEVPDAAVTAFFEAFAARLADDAVWAAIAGANARDVEQ
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARARGRSTTRLAVSDAMRRDMIEGLRAWAGAEAARGRVLERVEHPGWTVEQVVAPLGVVG
HHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEE
FVFEGRPNVFADATGVIRAGNTVVFRIGSDALGTARAIVAEALDPAITEAGLPEGCAALV
EEECCCCCEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHCHHHHHCCCCHHHHHHH
DSPAHAAGWAMFADPRLSLAVARGSGAAVAQLGAIARQAGTPVSLHGTGGAWMVADAAAD
CCCCHHHCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCC
ADRFFAAAYHSLDRKVCNTLNTCCIVEARADELVPVFLEALRKAGERRRGCKLHVAEQDL
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHH
SRLPEAWRAGRGVVVRAEGPREEPLVEPLADAELGREWEWEETPEVSLRIVADLAEAAAL
HHCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
FNAHSPRFVAALISEDPAAHARFFAAVDAPFVGDGFTRWVDGQYALKKPELGLSNWENGR
HCCCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCE
LFARGGVLAGDGVFSVRTRVTQADPHLDRGGAPTPPRGS
EEEECCEEECCCEEEHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDDGGTSRRTAGRLESLTPGQAIPFGGDRVAHVSPQLAAAFRAGDRLLVVQDSGDLLHV
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEEECCCCEEEC
PAAEQATAAGAVGRAAAAFARMGEVPDAAVTAFFEAFAARLADDAVWAAIAGANARDVEQ
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARARGRSTTRLAVSDAMRRDMIEGLRAWAGAEAARGRVLERVEHPGWTVEQVVAPLGVVG
HHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEE
FVFEGRPNVFADATGVIRAGNTVVFRIGSDALGTARAIVAEALDPAITEAGLPEGCAALV
EEECCCCCEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHCHHHHHCCCCHHHHHHH
DSPAHAAGWAMFADPRLSLAVARGSGAAVAQLGAIARQAGTPVSLHGTGGAWMVADAAAD
CCCCHHHCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCC
ADRFFAAAYHSLDRKVCNTLNTCCIVEARADELVPVFLEALRKAGERRRGCKLHVAEQDL
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECHHHH
SRLPEAWRAGRGVVVRAEGPREEPLVEPLADAELGREWEWEETPEVSLRIVADLAEAAAL
HHCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
FNAHSPRFVAALISEDPAAHARFFAAVDAPFVGDGFTRWVDGQYALKKPELGLSNWENGR
HCCCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCE
LFARGGVLAGDGVFSVRTRVTQADPHLDRGGAPTPPRGS
EEEECCEEECCCEEEHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA