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The map label for this gene is ahcY [H]

Identifier: 197103559

GI number: 197103559

Start: 86911

End: 88302

Strand: Direct

Name: ahcY [H]

Synonym: PHZ_c0093

Alternate gene names: 197103559

Gene position: 86911-88302 (Clockwise)

Preceding gene: 197103558

Following gene: 197103560

Centisome position: 2.17

GC content: 64.8

Gene sequence:

>1392_bases
ATGACCGACTACGTCGTGAAGGACATTTCGCTCGCCGACTGGGGCCGCAAGGAAATCGAGATCGCCGAGACCGAAATGCC
GGGCCTCATGGCGGTGCGCGAGGAATTCGCCAAGGCCCAGCCCCTGAAGGGCGCTCGGGTCGCGGGCTCGCTGCACATGA
CGATCCAGACCGCGGTCCTGATCGAGACCCTGGAGGCTCTCGGCGCCGAGGTGCGCTGGGCTTCGTGCAACATCTTCTCC
ACCCAGGACCACGCCGCCGCCGCCATCGCGGTGAAGGGCACGCCGGTGTTCGCCATCAAGGGCGAGACCCTGATCGAGTA
CTGGGAATACGCCCACCGGATCTTCGAATGGGCCGACGGCGGCTACCCGAACATGATCCTGGACGACGGCGGCGACGCGA
CCCTGCTGTGCGTCCTCGGGCCCAAGGCCGAAGCCGATCCTTCGATCCTGAACAATCCTCAGAACGAGGAAGAGGAAGCG
CTCTACACGGTGATGAAGCGCTACCTGAAGGAGAAGCCGGGCTTCTATTCGGCGATCCGCGCCGCCATCAAGGGCGTGTC
GGAAGAGACCACCACGGGCGTCCACCGCCTGTACCAGATGGCCGAGCGGGGCGAGCTGCCGTTCCCGGCGATCAACGTCA
ACGACAGCGTGACGAAGTCGAAGTTCGACAACCTCTACGGCTGCCGCGAGAGCCTGGTGGACGCCATCCGCCGCGGCACG
GACGTGATGCTGGCCGGCAAGACCGCCGTGGTCATGGGCTACGGCGACGTGGGCAAGGGCTCGGCCGCCTCGCTGCGCAA
CGGCGGCGCCCGGGTCATGGTCACCGAGGTCGACCCGATCTGCGCTCTGCAGGCGGCGATGGAAGGCTATGAGGTCGTGA
CCGTCGAGGACGTGGCCGACAAGGCCGACATCTTCGTCACCGCCACCGGCAACAAGGACGTCCTCACCGTCGACCACATG
CGGCGGATGAAGAACAACGCCATCGTGGCGAACATCGGCCACTTCGATTCCGAGATCCAGATCGCCGGCCTGCGCAACTT
CAAGTGGGACAAGATCAAGGATCAGGTCCACCACGTGGAGTTCCCGGACGGCAAGAAGATCATCGTGCTGTCGGAAGGCC
GCCTGGTGAACCTCGGCAACGCCACGGGCCACCCCAGCTTCGTCATGTCGGCCTCGTTCACCAACCAGACGCTGGCCCAG
ATCGAGCTGTGGCAGAACGGCGCGAAGTACGAGAAGCGCGTCTACACCCTGCCCAAGCACCTCGACGAGAAGGTGGCCAT
GCTGCACCTCGAGAAGCTCGGCGCGAAGCTGACCAAGCTCTCCAAGGAACAGGCGGACTACATCGGCGTGACGCCGGAAG
GCCCGTTCAAGCCCGAACACTACCGCTACTAG

Upstream 100 bases:

>100_bases
CCTGAGCCCGGGACATAAAGACTTCTTTATATGATTGTTGCGGCTGGCCGCCCCGGCGGCTATAGAGCGCGCAACCGAAC
TTCCCCCTTTTGAGGACGCC

Downstream 100 bases:

>100_bases
GGCTTTCGGAGCGGCGCGCGGGGGCTATGGTCAGGCTGTGCCCTTAGCCCTCGTCCTCTCCTCCTTCGTGGCGGCCAGCC
GGATCGGCGGCGGGGCCCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTDYVVKDISLADWGRKEIEIAETEMPGLMAVREEFAKAQPLKGARVAGSLHMTIQTAVLIETLEALGAEVRWASCNIFS
TQDHAAAAIAVKGTPVFAIKGETLIEYWEYAHRIFEWADGGYPNMILDDGGDATLLCVLGPKAEADPSILNNPQNEEEEA
LYTVMKRYLKEKPGFYSAIRAAIKGVSEETTTGVHRLYQMAERGELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGT
DVMLAGKTAVVMGYGDVGKGSAASLRNGGARVMVTEVDPICALQAAMEGYEVVTVEDVADKADIFVTATGNKDVLTVDHM
RRMKNNAIVANIGHFDSEIQIAGLRNFKWDKIKDQVHHVEFPDGKKIIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQ
IELWQNGAKYEKRVYTLPKHLDEKVAMLHLEKLGAKLTKLSKEQADYIGVTPEGPFKPEHYRY

Sequences:

>Translated_463_residues
MTDYVVKDISLADWGRKEIEIAETEMPGLMAVREEFAKAQPLKGARVAGSLHMTIQTAVLIETLEALGAEVRWASCNIFS
TQDHAAAAIAVKGTPVFAIKGETLIEYWEYAHRIFEWADGGYPNMILDDGGDATLLCVLGPKAEADPSILNNPQNEEEEA
LYTVMKRYLKEKPGFYSAIRAAIKGVSEETTTGVHRLYQMAERGELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGT
DVMLAGKTAVVMGYGDVGKGSAASLRNGGARVMVTEVDPICALQAAMEGYEVVTVEDVADKADIFVTATGNKDVLTVDHM
RRMKNNAIVANIGHFDSEIQIAGLRNFKWDKIKDQVHHVEFPDGKKIIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQ
IELWQNGAKYEKRVYTLPKHLDEKVAMLHLEKLGAKLTKLSKEQADYIGVTPEGPFKPEHYRY
>Mature_462_residues
TDYVVKDISLADWGRKEIEIAETEMPGLMAVREEFAKAQPLKGARVAGSLHMTIQTAVLIETLEALGAEVRWASCNIFST
QDHAAAAIAVKGTPVFAIKGETLIEYWEYAHRIFEWADGGYPNMILDDGGDATLLCVLGPKAEADPSILNNPQNEEEEAL
YTVMKRYLKEKPGFYSAIRAAIKGVSEETTTGVHRLYQMAERGELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTD
VMLAGKTAVVMGYGDVGKGSAASLRNGGARVMVTEVDPICALQAAMEGYEVVTVEDVADKADIFVTATGNKDVLTVDHMR
RMKNNAIVANIGHFDSEIQIAGLRNFKWDKIKDQVHHVEFPDGKKIIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQI
ELWQNGAKYEKRVYTLPKHLDEKVAMLHLEKLGAKLTKLSKEQADYIGVTPEGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=57.5757575757576, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=57.2727272727273, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.247311827957, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.247311827957, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.247311827957, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.247311827957, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.9569892473118, Blast_Score=430, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.7849462365591, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=56.9037656903766, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=58.8744588744589, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=48.9270386266094, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=50, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=49.8920086393089, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51058; Mature: 50927

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYVVKDISLADWGRKEIEIAETEMPGLMAVREEFAKAQPLKGARVAGSLHMTIQTAVL
CCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECEEEEHHHHHHH
IETLEALGAEVRWASCNIFSTQDHAAAAIAVKGTPVFAIKGETLIEYWEYAHRIFEWADG
HHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHCCC
GYPNMILDDGGDATLLCVLGPKAEADPSILNNPQNEEEEALYTVMKRYLKEKPGFYSAIR
CCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
AAIKGVSEETTTGVHRLYQMAERGELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGT
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DVMLAGKTAVVMGYGDVGKGSAASLRNGGARVMVTEVDPICALQAAMEGYEVVTVEDVAD
EEEEECCEEEEEECCCCCCCCHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCC
KADIFVTATGNKDVLTVDHMRRMKNNAIVANIGHFDSEIQIAGLRNFKWDKIKDQVHHVE
CCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHEEE
FPDGKKIIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWQNGAKYEKRVYTLPKH
CCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHCHHH
LDEKVAMLHLEKLGAKLTKLSKEQADYIGVTPEGPFKPEHYRY
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TDYVVKDISLADWGRKEIEIAETEMPGLMAVREEFAKAQPLKGARVAGSLHMTIQTAVL
CCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECEEEEHHHHHHH
IETLEALGAEVRWASCNIFSTQDHAAAAIAVKGTPVFAIKGETLIEYWEYAHRIFEWADG
HHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCEEEEECCHHHHHHHHHHHHHHHHCCC
GYPNMILDDGGDATLLCVLGPKAEADPSILNNPQNEEEEALYTVMKRYLKEKPGFYSAIR
CCCCEEEECCCCEEEEEEECCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
AAIKGVSEETTTGVHRLYQMAERGELPFPAINVNDSVTKSKFDNLYGCRESLVDAIRRGT
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DVMLAGKTAVVMGYGDVGKGSAASLRNGGARVMVTEVDPICALQAAMEGYEVVTVEDVAD
EEEEECCEEEEEECCCCCCCCHHHHCCCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCC
KADIFVTATGNKDVLTVDHMRRMKNNAIVANIGHFDSEIQIAGLRNFKWDKIKDQVHHVE
CCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHEEE
FPDGKKIIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWQNGAKYEKRVYTLPKH
CCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHCHHH
LDEKVAMLHLEKLGAKLTKLSKEQADYIGVTPEGPFKPEHYRY
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]