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The map label for this gene is fabB [H]

Identifier: 197103494

GI number: 197103494

Start: 23951

End: 25165

Strand: Reverse

Name: fabB [H]

Synonym: PHZ_c0028

Alternate gene names: 197103494

Gene position: 25165-23951 (Counterclockwise)

Preceding gene: 197103495

Following gene: 197103493

Centisome position: 0.63

GC content: 70.45

Gene sequence:

>1215_bases
ATGCGCCGCGTCGTCATCACGGGGATGGGTATCGTCTCGTCCATCGGCAACAACCCGGACGAGGTCCTGGCCTCGCTGCG
TGAGGCGAAGTCCGGCGTCACCGCCGCGCCCGAGTACGCCGAGCTCGGCTTCCGCTGCCAGGTCCACGCCCCGCCCCGGA
TCGACTGGGAGGCCATGGTCGACCGCCGCGCCGCCCGCTTCCTGGCCCAGGGCACCGCCTTCGGCCACATCGCCATGGAG
CAGGCGATCGCCGACTCCGGCCTGACCGAGGCCGAGGTCAGCCACGAGAAGACCGGCCTGATCGTCGGCGCGGGCGGCCC
CTCGACCCGCGCCATCGTCGAATCCGCCGAGATCGCCCGCACCAAGGGCCCCAAGCGCGTGGGCCCCTTCGCGGTGCCCA
AGGCGATGAGCTCGGGCCCCTCGGCCACGCTCGCCACCTGGTTCAAGATCCGCGGCCTGAACTTCTCGATCAGCTCGGCC
TGCGCCACCTCCACCCACTGCATCGGCTCGGCCTACGAGCAGATCCTGATGGGCAAGCAGGACGTGGTGTTCGCCGGCGG
GACCGAGGAGCTGGACTGGACCCTCAGCGTGCTCTTCGACGCCATGGGCGCCATGAGCTCGAAGTTCAACGACCGGCCGG
CCGTCGCCAGCCGGGCCTACGACGTCGACCGCGACGGCTTCGTCATCGCCGGCGGCGCCGGGATCCTCGTCCTCGAGGAG
TACGAGCGCGCCAAGGCCCGCGGGGCCAAAATCTACGGCGAGATCGTCGGCTATGCGGCCAATTCGGACGGCTTCGACAT
GGTGGCCCCCTCGGGCGAGGGCGCGGCCCGCTGCATGAAGCTGGCCATGCAGGACCTCGGCGGGCGCCGGATCGACTACC
TGAACCCGCACGGCACCGGCACGCCCGTGGGCGACGTGAAGGAGATGGAGGCCGTGCGCGCGGTGTTCGGCGAGACCGCC
CCGCTGATCTCGTCCACCAAGTCGCTGACCGGCCACAGCCTCGGCGCGGCCGGGGCCCAGGAGGCGATCTACAGCCTGCT
GATGCTCAACAACGGCTTCGTCGCCGAGAGCGCCCACATCGAGAACCTCGACCCCGCCTTCGAGGGCATGCCGATCGTCC
GCAAGCGCGAGGACCGGGAGCTCGAGACGGTGATGAGCAACTCCTTCGGCTTCGGCGGCACCAACGGCTGCCTGGTGATG
GCCAAGGCGTCCTAG

Upstream 100 bases:

>100_bases
AGCCCATCTATGAGGCGACGGATCTGCGCGTGGGCCTGTTCCGGGCCGAAGACCTGGCCTGACGGCCCGACAAAGAGAAG
CGTACGGAGGAGACGGCCAG

Downstream 100 bases:

>100_bases
GCCCTGACCGGCGTCCCGCCCAACCTCCCGCTGGGCGTGCCCGCGCCTCCCCGCCGTCCGACGCGCGAGGAGTGCTGCGG
CCGCGGCTGCGACCCCTGCA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MRRVVITGMGIVSSIGNNPDEVLASLREAKSGVTAAPEYAELGFRCQVHAPPRIDWEAMVDRRAARFLAQGTAFGHIAME
QAIADSGLTEAEVSHEKTGLIVGAGGPSTRAIVESAEIARTKGPKRVGPFAVPKAMSSGPSATLATWFKIRGLNFSISSA
CATSTHCIGSAYEQILMGKQDVVFAGGTEELDWTLSVLFDAMGAMSSKFNDRPAVASRAYDVDRDGFVIAGGAGILVLEE
YERAKARGAKIYGEIVGYAANSDGFDMVAPSGEGAARCMKLAMQDLGGRRIDYLNPHGTGTPVGDVKEMEAVRAVFGETA
PLISSTKSLTGHSLGAAGAQEAIYSLLMLNNGFVAESAHIENLDPAFEGMPIVRKREDRELETVMSNSFGFGGTNGCLVM
AKAS

Sequences:

>Translated_404_residues
MRRVVITGMGIVSSIGNNPDEVLASLREAKSGVTAAPEYAELGFRCQVHAPPRIDWEAMVDRRAARFLAQGTAFGHIAME
QAIADSGLTEAEVSHEKTGLIVGAGGPSTRAIVESAEIARTKGPKRVGPFAVPKAMSSGPSATLATWFKIRGLNFSISSA
CATSTHCIGSAYEQILMGKQDVVFAGGTEELDWTLSVLFDAMGAMSSKFNDRPAVASRAYDVDRDGFVIAGGAGILVLEE
YERAKARGAKIYGEIVGYAANSDGFDMVAPSGEGAARCMKLAMQDLGGRRIDYLNPHGTGTPVGDVKEMEAVRAVFGETA
PLISSTKSLTGHSLGAAGAQEAIYSLLMLNNGFVAESAHIENLDPAFEGMPIVRKREDRELETVMSNSFGFGGTNGCLVM
AKAS
>Mature_404_residues
MRRVVITGMGIVSSIGNNPDEVLASLREAKSGVTAAPEYAELGFRCQVHAPPRIDWEAMVDRRAARFLAQGTAFGHIAME
QAIADSGLTEAEVSHEKTGLIVGAGGPSTRAIVESAEIARTKGPKRVGPFAVPKAMSSGPSATLATWFKIRGLNFSISSA
CATSTHCIGSAYEQILMGKQDVVFAGGTEELDWTLSVLFDAMGAMSSKFNDRPAVASRAYDVDRDGFVIAGGAGILVLEE
YERAKARGAKIYGEIVGYAANSDGFDMVAPSGEGAARCMKLAMQDLGGRRIDYLNPHGTGTPVGDVKEMEAVRAVFGETA
PLISSTKSLTGHSLGAAGAQEAIYSLLMLNNGFVAESAHIENLDPAFEGMPIVRKREDRELETVMSNSFGFGGTNGCLVM
AKAS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=34.9282296650718, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI41872631, Length=334, Percent_Identity=26.6467065868263, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI223972627, Length=163, Percent_Identity=37.4233128834356, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=61.1386138613861, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=39.4160583941606, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=34.2168674698795, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=37.9699248120301, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=343, Percent_Identity=25.3644314868805, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=271, Percent_Identity=27.3062730627306, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=29.6380090497738, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=37.6470588235294, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI221330659, Length=335, Percent_Identity=27.1641791044776, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI19920632, Length=335, Percent_Identity=27.1641791044776, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581345, Length=336, Percent_Identity=22.9166666666667, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42567; Mature: 42567

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGIVSSIGNNPDEVLASLREAKSGVTAAPEYAELGFRCQVHAPPRIDWEAMV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCCCHHHHH
DRRAARFLAQGTAFGHIAMEQAIADSGLTEAEVSHEKTGLIVGAGGPSTRAIVESAEIAR
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
TKGPKRVGPFAVPKAMSSGPSATLATWFKIRGLNFSISSACATSTHCIGSAYEQILMGKQ
CCCCCCCCCCCCCHHHCCCCCHHEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGTEELDWTLSVLFDAMGAMSSKFNDRPAVASRAYDVDRDGFVIAGGAGILVLEE
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCEEEEEC
YERAKARGAKIYGEIVGYAANSDGFDMVAPSGEGAARCMKLAMQDLGGRRIDYLNPHGTG
HHHHHHCCCCEEEEHEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCC
TPVGDVKEMEAVRAVFGETAPLISSTKSLTGHSLGAAGAQEAIYSLLMLNNGFVAESAHI
CCCCCHHHHHHHHHHHCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCC
ENLDPAFEGMPIVRKREDRELETVMSNSFGFGGTNGCLVMAKAS
CCCCHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRRVVITGMGIVSSIGNNPDEVLASLREAKSGVTAAPEYAELGFRCQVHAPPRIDWEAMV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCCCHHHHH
DRRAARFLAQGTAFGHIAMEQAIADSGLTEAEVSHEKTGLIVGAGGPSTRAIVESAEIAR
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
TKGPKRVGPFAVPKAMSSGPSATLATWFKIRGLNFSISSACATSTHCIGSAYEQILMGKQ
CCCCCCCCCCCCCHHHCCCCCHHEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGTEELDWTLSVLFDAMGAMSSKFNDRPAVASRAYDVDRDGFVIAGGAGILVLEE
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCEEEEEC
YERAKARGAKIYGEIVGYAANSDGFDMVAPSGEGAARCMKLAMQDLGGRRIDYLNPHGTG
HHHHHHCCCCEEEEHEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCC
TPVGDVKEMEAVRAVFGETAPLISSTKSLTGHSLGAAGAQEAIYSLLMLNNGFVAESAHI
CCCCCHHHHHHHHHHHCCCCHHHHCCHHCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCC
ENLDPAFEGMPIVRKREDRELETVMSNSFGFGGTNGCLVMAKAS
CCCCHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]