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The map label for this gene is hmgA [H]

Identifier: 195978201

GI number: 195978201

Start: 1115296

End: 1116582

Strand: Direct

Name: hmgA [H]

Synonym: Sez_1080

Alternate gene names: 195978201

Gene position: 1115296-1116582 (Clockwise)

Preceding gene: 195978200

Following gene: 195978209

Centisome position: 55.1

GC content: 46.46

Gene sequence:

>1287_bases
ATGATGACAAAAACTAAACCAAATTGGGCCGGCTTTTATAAAAAAAGCCTTGCAGAACGCATTCAACAGCTCGCAGATGA
CCAGCTGCTTGGCCCGCAGCAGCAAAAGCTGTTAGAGACAGACCAGCTCTTACCCATTGCTATTGCCAATCAAATGACCG
AAAATGTCATCGGTCGACTGGCTCTGCCTTTTAGTCTAGCCCCTGATTTTCTGATCAATGGGCATACCTATCAGGTCCCC
TTTGTGACTGAAGAGCCTTCTGTTGTTGCTGCTGCTTCCTTTGCTGCCAAAATCATCAAGCGATCAGGTGGCTTTCAGAC
TGAGGTACTCAGTCGTCAAATGCTTGGGCAGGTAGCTCTTTATGATGTTAAAGATGACGAGCAGGCTAGGCTGGCTATTC
TAGCTAACGCAGATACATTGATTGATATTGCAAACAATGCCTACCCTTCTATTGTTAAGCGTGGTGGTGGTGCAAAGAGC
CTTACTGTTGAGCGTAAGGAGGACTTTTTCATTGTCTATCTGAGCGTTGATACCCAAGAGGCTATGGGAGCCAACATCGT
TAACACGATGATGGAGGCTTTAGTACCTGATTTGGAGGCCCTAAGCGGTGGTCAATGCTTAATAGCTATCCTCTCAAACT
ATGCAACAAAAGCTCTAGTTAGTGCTAGGTGTCAGGTTGACCTCAGATACTTAAGTCGACATAAGGAAGAAGCCCAGCAA
TTAGCCAAAAAAATAGAACTGGCAAGTAAACTAGCGCAGATTGACCCTTACCGAGCAGCAACGCATAATAAGGGAATCTT
CAATGGAATCGACGCAGTAGCTATAGCTACTGGAAATGACTGGAGAGCTATTGAGGCTGGAGCACATGCCTACGCCGCAA
GGAATGGCGCTTATAGAGGACTAAGTAGCTGGCACGTTGATACATCTAAAAATAGCTTATGTGGAGAGTTAACACTGCCA
ATGCCCATTGCCAGTAAAGGGGGCTCGATTGGTCTCAACCCAACTGTCAATGTTGCTCGCAGCCTTTTAGAGCAACCAAA
TGCCAAGGTACTCGCCCAAATCATCACCGCAGTTGGGTTGGCGCAAAATTTTGCTGCTCTAAAGGCCTTGACCTCAACTG
GTATTCAGGCTGGTCACATGAAGCTGCAGGCCAAGTCTCTAGCTCTATTAGCAGGTGCTAGTGAGCAGGAGGTGCCTCAA
CTAGTCAAGGCTTTACTAAAGGATAAGCCAATGAACCTAGAAAAGGCAGGACAGCTCTTAACAGCCATACGATTAAGCCA
ATCATAG

Upstream 100 bases:

>100_bases
GAGCCTAGTCTAGATCAAGATGGCAATGCCAGCTTTTCACCCTATCTAACTGGCAGGTTTGCCCTCAAAGAAATTAAGGA
ACACCAACGAATTTATCAAG

Downstream 100 bases:

>100_bases
ACTAAAAACACTTGGTAACAGCTTTAATGGCAGCTACCAAGTGTTTTCATATTCTTTAGATGTTAATGTAAGCATAGACT
TAACCTCAGTCTCAGTAACC

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase HmgA

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MMTKTKPNWAGFYKKSLAERIQQLADDQLLGPQQQKLLETDQLLPIAIANQMTENVIGRLALPFSLAPDFLINGHTYQVP
FVTEEPSVVAAASFAAKIIKRSGGFQTEVLSRQMLGQVALYDVKDDEQARLAILANADTLIDIANNAYPSIVKRGGGAKS
LTVERKEDFFIVYLSVDTQEAMGANIVNTMMEALVPDLEALSGGQCLIAILSNYATKALVSARCQVDLRYLSRHKEEAQQ
LAKKIELASKLAQIDPYRAATHNKGIFNGIDAVAIATGNDWRAIEAGAHAYAARNGAYRGLSSWHVDTSKNSLCGELTLP
MPIASKGGSIGLNPTVNVARSLLEQPNAKVLAQIITAVGLAQNFAALKALTSTGIQAGHMKLQAKSLALLAGASEQEVPQ
LVKALLKDKPMNLEKAGQLLTAIRLSQS

Sequences:

>Translated_428_residues
MMTKTKPNWAGFYKKSLAERIQQLADDQLLGPQQQKLLETDQLLPIAIANQMTENVIGRLALPFSLAPDFLINGHTYQVP
FVTEEPSVVAAASFAAKIIKRSGGFQTEVLSRQMLGQVALYDVKDDEQARLAILANADTLIDIANNAYPSIVKRGGGAKS
LTVERKEDFFIVYLSVDTQEAMGANIVNTMMEALVPDLEALSGGQCLIAILSNYATKALVSARCQVDLRYLSRHKEEAQQ
LAKKIELASKLAQIDPYRAATHNKGIFNGIDAVAIATGNDWRAIEAGAHAYAARNGAYRGLSSWHVDTSKNSLCGELTLP
MPIASKGGSIGLNPTVNVARSLLEQPNAKVLAQIITAVGLAQNFAALKALTSTGIQAGHMKLQAKSLALLAGASEQEVPQ
LVKALLKDKPMNLEKAGQLLTAIRLSQS
>Mature_428_residues
MMTKTKPNWAGFYKKSLAERIQQLADDQLLGPQQQKLLETDQLLPIAIANQMTENVIGRLALPFSLAPDFLINGHTYQVP
FVTEEPSVVAAASFAAKIIKRSGGFQTEVLSRQMLGQVALYDVKDDEQARLAILANADTLIDIANNAYPSIVKRGGGAKS
LTVERKEDFFIVYLSVDTQEAMGANIVNTMMEALVPDLEALSGGQCLIAILSNYATKALVSARCQVDLRYLSRHKEEAQQ
LAKKIELASKLAQIDPYRAATHNKGIFNGIDAVAIATGNDWRAIEAGAHAYAARNGAYRGLSSWHVDTSKNSLCGELTLP
MPIASKGGSIGLNPTVNVARSLLEQPNAKVLAQIITAVGLAQNFAALKALTSTGIQAGHMKLQAKSLALLAGASEQEVPQ
LVKALLKDKPMNLEKAGQLLTAIRLSQS

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46044; Mature: 46044

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTKTKPNWAGFYKKSLAERIQQLADDQLLGPQQQKLLETDQLLPIAIANQMTENVIGRL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALPFSLAPDFLINGHTYQVPFVTEEPSVVAAASFAAKIIKRSGGFQTEVLSRQMLGQVAL
CCCCCCCCCCEECCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEE
YDVKDDEQARLAILANADTLIDIANNAYPSIVKRGGGAKSLTVERKEDFFIVYLSVDTQE
EECCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCCCEEEEEECCCEEEEEEEECCHH
AMGANIVNTMMEALVPDLEALSGGQCLIAILSNYATKALVSARCQVDLRYLSRHKEEAQQ
HHCHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKKIELASKLAQIDPYRAATHNKGIFNGIDAVAIATGNDWRAIEAGAHAYAARNGAYRG
HHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCCCC
LSSWHVDTSKNSLCGELTLPMPIASKGGSIGLNPTVNVARSLLEQPNAKVLAQIITAVGL
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AQNFAALKALTSTGIQAGHMKLQAKSLALLAGASEQEVPQLVKALLKDKPMNLEKAGQLL
HHHHHHHHHHHHCCCCHHHEEEHHHHHHEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHH
TAIRLSQS
HHHHHCCC
>Mature Secondary Structure
MMTKTKPNWAGFYKKSLAERIQQLADDQLLGPQQQKLLETDQLLPIAIANQMTENVIGRL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALPFSLAPDFLINGHTYQVPFVTEEPSVVAAASFAAKIIKRSGGFQTEVLSRQMLGQVAL
CCCCCCCCCCEECCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEE
YDVKDDEQARLAILANADTLIDIANNAYPSIVKRGGGAKSLTVERKEDFFIVYLSVDTQE
EECCCCCCCEEEEEECCCCEEEECCCCCHHHHHCCCCCCEEEEEECCCEEEEEEEECCHH
AMGANIVNTMMEALVPDLEALSGGQCLIAILSNYATKALVSARCQVDLRYLSRHKEEAQQ
HHCHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKKIELASKLAQIDPYRAATHNKGIFNGIDAVAIATGNDWRAIEAGAHAYAARNGAYRG
HHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHCCCCCCC
LSSWHVDTSKNSLCGELTLPMPIASKGGSIGLNPTVNVARSLLEQPNAKVLAQIITAVGL
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AQNFAALKALTSTGIQAGHMKLQAKSLALLAGASEQEVPQLVKALLKDKPMNLEKAGQLL
HHHHHHHHHHHHCCCCHHHEEEHHHHHHEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHH
TAIRLSQS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]