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The map label for this gene is pdp [H]

Identifier: 195978060

GI number: 195978060

Start: 971026

End: 972303

Strand: Direct

Name: pdp [H]

Synonym: Sez_0933

Alternate gene names: 195978060

Gene position: 971026-972303 (Clockwise)

Preceding gene: 195978059

Following gene: 195978061

Centisome position: 47.97

GC content: 43.97

Gene sequence:

>1278_bases
ATGAGAGCAGTTGATTTAATCCAAAAAAAGCGTGATGGTAAAGAGCTATCTACCGAAGAGATCCAGTGGCTGATTAATGG
TTATGCCAATGGTACTGTGCCAGATTATCAAATGTCGGCTTTTGCAATGGCGATCTATTTCAAGGGAATGTCTACACGAG
AAACTCGCGATTTGACCATGAGTATGGTTGAGACAGGTGAGCAGATTGATTTGTCAGCTATAGCTGGTATCAAAACGGAC
AAGCACTCAACAGGTGGTGTTGGTGATAAGGTAACACTGATTTTAGCTCCTTTAGTTGCCAGCTTTGGTGTTCCTGTAGC
AAAAATGAGCGGACGCGGCTTAGGTCACACCGGTGGAACGCTTGATAAGCTAGAGTCTATCAAGGGCTTTCAGATTGGTC
GGACCCAAGAGGAATTTATCAAGCAGGTACAAGAGATCGGACTTTCAGTTATTGGACAGTCAGATAAGCTTGTGAAGGCA
GATAAGCTGCTTTATGCTCTTCGTGATGTGACGGCAACCGTTGATATTGTTCCTTTGATTGCAAGCTCTGTTATGAGTAA
GAAAATTGCTGCTGGCGCTGATAGTATTTTGCTAGATGTTACCGTTGGTGACGGTGCCTTTATGAAGACTATTGAAGATG
CTGAGAAGCTGTCTAGACTGATGGTTGACCTTGGTAAGGAGGTTGGGCGTCAGACAGTGGCTGTCATTACAGATATGAGT
CAGCCTCTTGGTCGTGCTATCGGTAATCGCTTAGAGGTGCTAGAGGCAATTGATATCATGAAAGGCAAGGGACGCAAGGA
TATTACTCACTTTATTTGTGAGCTAGCTCAGATTATGCTGGAGCTTGCTGGTGCTCAACACTCTCTTGAGGATATTCACC
ATCATTTGGTTGGCGGAGCAGCCTTGAAAAAATTAGAAGAGATGGTTGTTTATCAAGGAGGTGATCTTGAGGACCTTTAT
CGTCCATCACAGGCGGCTGTTCAAACAGAGGTTTTTGCGTCAGAAGATGGTTACATCATAGCATTGCCTGCTCTTGAGTT
TGGATTGTTTGCAATGAGGCTGGGTGCTGGTAGAGCAGTCAAAACAGATAGTCTGGATTATGAAACAGGGATTGTCTTTG
ACAAGAAGGTTGGTGACGCTGTCGCTAAGGGAGAGCGCATTGCAGTTGTCTTTTCACAGGAAGCCCTAGACGAAAAAGTG
CTTACAGAATTTGAAAAAAATGTTAAAATAGGGGCGGAACACCTAGAGGCTAACGAAATTATCAAAATCATTTCCTAA

Upstream 100 bases:

>100_bases
GAGCTCAAGTGTAAAAAGTGGTATTAAAAAGCATAGCGGTATTTTAGTAAGAGTTGCCTTCTAATATCACTATTTTCTCA
GAGCTTTTGGTATCTTGTTG

Downstream 100 bases:

>100_bases
GGAGGAGTATAACATGAATATTAACAAGTATATTGACCACACACTACTAAAAGCTGACAGCGTTCAATCGCAGCTTGACC
AATTAATTGAGGAGGCTAAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRAVDLIQKKRDGKELSTEEIQWLINGYANGTVPDYQMSAFAMAIYFKGMSTRETRDLTMSMVETGEQIDLSAIAGIKTD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIKGFQIGRTQEEFIKQVQEIGLSVIGQSDKLVKA
DKLLYALRDVTATVDIVPLIASSVMSKKIAAGADSILLDVTVGDGAFMKTIEDAEKLSRLMVDLGKEVGRQTVAVITDMS
QPLGRAIGNRLEVLEAIDIMKGKGRKDITHFICELAQIMLELAGAQHSLEDIHHHLVGGAALKKLEEMVVYQGGDLEDLY
RPSQAAVQTEVFASEDGYIIALPALEFGLFAMRLGAGRAVKTDSLDYETGIVFDKKVGDAVAKGERIAVVFSQEALDEKV
LTEFEKNVKIGAEHLEANEIIKIIS

Sequences:

>Translated_425_residues
MRAVDLIQKKRDGKELSTEEIQWLINGYANGTVPDYQMSAFAMAIYFKGMSTRETRDLTMSMVETGEQIDLSAIAGIKTD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIKGFQIGRTQEEFIKQVQEIGLSVIGQSDKLVKA
DKLLYALRDVTATVDIVPLIASSVMSKKIAAGADSILLDVTVGDGAFMKTIEDAEKLSRLMVDLGKEVGRQTVAVITDMS
QPLGRAIGNRLEVLEAIDIMKGKGRKDITHFICELAQIMLELAGAQHSLEDIHHHLVGGAALKKLEEMVVYQGGDLEDLY
RPSQAAVQTEVFASEDGYIIALPALEFGLFAMRLGAGRAVKTDSLDYETGIVFDKKVGDAVAKGERIAVVFSQEALDEKV
LTEFEKNVKIGAEHLEANEIIKIIS
>Mature_425_residues
MRAVDLIQKKRDGKELSTEEIQWLINGYANGTVPDYQMSAFAMAIYFKGMSTRETRDLTMSMVETGEQIDLSAIAGIKTD
KHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIKGFQIGRTQEEFIKQVQEIGLSVIGQSDKLVKA
DKLLYALRDVTATVDIVPLIASSVMSKKIAAGADSILLDVTVGDGAFMKTIEDAEKLSRLMVDLGKEVGRQTVAVITDMS
QPLGRAIGNRLEVLEAIDIMKGKGRKDITHFICELAQIMLELAGAQHSLEDIHHHLVGGAALKKLEEMVVYQGGDLEDLY
RPSQAAVQTEVFASEDGYIIALPALEFGLFAMRLGAGRAVKTDSLDYETGIVFDKKVGDAVAKGERIAVVFSQEALDEKV
LTEFEKNVKIGAEHLEANEIIKIIS

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=398, Percent_Identity=38.6934673366834, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4503445, Length=398, Percent_Identity=38.6934673366834, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI166158922, Length=398, Percent_Identity=38.6934673366834, Blast_Score=248, Evalue=5e-66,
Organism=Escherichia coli, GI1790842, Length=407, Percent_Identity=38.8206388206388, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45984; Mature: 45984

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVDLIQKKRDGKELSTEEIQWLINGYANGTVPDYQMSAFAMAIYFKGMSTRETRDLTM
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
SMVETGEQIDLSAIAGIKTDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
LDKLESIKGFQIGRTQEEFIKQVQEIGLSVIGQSDKLVKADKLLYALRDVTATVDIVPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADSILLDVTVGDGAFMKTIEDAEKLSRLMVDLGKEVGRQTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QPLGRAIGNRLEVLEAIDIMKGKGRKDITHFICELAQIMLELAGAQHSLEDIHHHLVGGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALKKLEEMVVYQGGDLEDLYRPSQAAVQTEVFASEDGYIIALPALEFGLFAMRLGAGRAV
HHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHEECCCCEEEEECHHHHHHHHHHHCCCCEE
KTDSLDYETGIVFDKKVGDAVAKGERIAVVFSQEALDEKVLTEFEKNVKIGAEHLEANEI
ECCCCCCCCCEEEECHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHCHHHH
IKIIS
HHHCC
>Mature Secondary Structure
MRAVDLIQKKRDGKELSTEEIQWLINGYANGTVPDYQMSAFAMAIYFKGMSTRETRDLTM
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
SMVETGEQIDLSAIAGIKTDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
LDKLESIKGFQIGRTQEEFIKQVQEIGLSVIGQSDKLVKADKLLYALRDVTATVDIVPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADSILLDVTVGDGAFMKTIEDAEKLSRLMVDLGKEVGRQTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
QPLGRAIGNRLEVLEAIDIMKGKGRKDITHFICELAQIMLELAGAQHSLEDIHHHLVGGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALKKLEEMVVYQGGDLEDLYRPSQAAVQTEVFASEDGYIIALPALEFGLFAMRLGAGRAV
HHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHEECCCCEEEEECHHHHHHHHHHHCCCCEE
KTDSLDYETGIVFDKKVGDAVAKGERIAVVFSQEALDEKVLTEFEKNVKIGAEHLEANEI
ECCCCCCCCCEEEECHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHCHHHH
IKIIS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA