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The map label for this gene is ygcA [C]

Identifier: 195977835

GI number: 195977835

Start: 730877

End: 732238

Strand: Direct

Name: ygcA [C]

Synonym: Sez_0703

Alternate gene names: 195977835

Gene position: 730877-732238 (Clockwise)

Preceding gene: 195977834

Following gene: 195977836

Centisome position: 36.11

GC content: 43.91

Gene sequence:

>1362_bases
ATGTTAAGTAAAAACGATATTGTTCAGGTGGAAATTTCTGATTTAAGCCATGATGGCTTAGGAATCGCTAAGCATGAAGG
CTTTGTTTTCTTTGTTGAAAATGCTCTTCCAGGTGAGATCATTCAGATGCGTGTCCTAAAGGTCAATAAAAACAGTGGCT
TTGGCAAGGTAGAGACCTATCTAACAACCTCACCGATGCGTCAAAAAAAGCTGGATGTGACCTATCTGCGTACAGGTATT
GCTGATTTGGGGCACTTGCTTTATCCGCAGCAGCTGCTCTTTAAGCAAAAGCAGGTTCAGGATAGTCTCTATAAGATTGC
AGGGATTAGCAATGTTGAGGTCAAAGAAACAATTGGTATGGAATATCCTTATGCTTATCGAAATAAAGCCCAGGTTCCTG
TTCGTCGTGTCAATGGTCAGCTAGAGACTGGTTTTTTCCGTAAGCATTCTCATGAGCTAGTACCGATTTCTGATTTTTAC
ATTCAGGATAAAGAAATTGATCGCTTGATCGCCTTTACACGCGACCTTTTGCGCCGTTTTGACATCAAGCCCTATGACGA
AAAAGAGCAGTCAGGCCTGATTCGTCATCTTGTGGTTCGTCGTGGGCATTATTCAGGAGAAATCATGCTGGTTTTAGTGA
CAACACGACCTAAAATCTTTCGTATCAACCAGATGATTGATCGCCTTGTTGCAGAATTTCCAGCGATTACTTCTATCCTG
CAAAATATCAATGACAAGCCTACTAATGTTATCTTTGGTAAGGCGTTTACAAGACTCTATGGAAAAGAGACAATCACAGA
TACGATCCTGGGCAATCAATACTGTATTTCTGCTCAGTCCTTTTATCAGGTCAATACGACAATGGCTGAAAAGCTCTATC
AAACAGCTATTGATTTTTCTGAATTGACCGCTGACGATGTGGTGATTGATGCCTATTCAGGCATTGGAACCATCGGGCTA
TCCTTTGCTAAAGAAGTCAAAGCAGTCTACGGTGTCGAAGTGATCGAAGCAGCAGTGCGTGATGCCGAGAAAAATGCAGC
GCTAAACGGTATTACCAATGCCCACTATGTCGCTGACAGCGCTGAAAATGCGATGGCAAACTGGTGTCAGGAGGGCATAA
AGCCAACGGTTATCATCGTAGACCCCCCACGAAAGGGACTAACTGAGAGCTTTATCAAGGCCAGTGCAGCGATGCAGCCT
GACAAAATAACCTATATATCCTGCAACCCCGCCACCATGGCGCGTGACATCAAGCGCTACGAGGAACTCGGCTATAAACT
CCAGAAAGTGCAGCCAGTAGACTTGTTTCCAATGACACATCATGTGGAGTGCGTAGTGTTGCTACAACGAAGCAAAGGGT
AA

Upstream 100 bases:

>100_bases
TATCTAAGCTGGGATTACGCTAAGATATGCTATAATGAAGGGTAACGATGGTTGCTCTTCTTTTTTGAGTGATTAGTGTA
GTAAAAGAAAAGGAAAGTAA

Downstream 100 bases:

>100_bases
AAATCCTTTATTTTAAGCACTTTTTCAAGCATTTTGTCTTTATTGAAAAGAGTGATTTTGACATAAAAAAGGTGCAAAAA
AAGTACATTGATGTGAACGT

Product: 23S rRNA-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLSKNDIVQVEISDLSHDGLGIAKHEGFVFFVENALPGEIIQMRVLKVNKNSGFGKVETYLTTSPMRQKKLDVTYLRTGI
ADLGHLLYPQQLLFKQKQVQDSLYKIAGISNVEVKETIGMEYPYAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDFY
IQDKEIDRLIAFTRDLLRRFDIKPYDEKEQSGLIRHLVVRRGHYSGEIMLVLVTTRPKIFRINQMIDRLVAEFPAITSIL
QNINDKPTNVIFGKAFTRLYGKETITDTILGNQYCISAQSFYQVNTTMAEKLYQTAIDFSELTADDVVIDAYSGIGTIGL
SFAKEVKAVYGVEVIEAAVRDAEKNAALNGITNAHYVADSAENAMANWCQEGIKPTVIIVDPPRKGLTESFIKASAAMQP
DKITYISCNPATMARDIKRYEELGYKLQKVQPVDLFPMTHHVECVVLLQRSKG

Sequences:

>Translated_453_residues
MLSKNDIVQVEISDLSHDGLGIAKHEGFVFFVENALPGEIIQMRVLKVNKNSGFGKVETYLTTSPMRQKKLDVTYLRTGI
ADLGHLLYPQQLLFKQKQVQDSLYKIAGISNVEVKETIGMEYPYAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDFY
IQDKEIDRLIAFTRDLLRRFDIKPYDEKEQSGLIRHLVVRRGHYSGEIMLVLVTTRPKIFRINQMIDRLVAEFPAITSIL
QNINDKPTNVIFGKAFTRLYGKETITDTILGNQYCISAQSFYQVNTTMAEKLYQTAIDFSELTADDVVIDAYSGIGTIGL
SFAKEVKAVYGVEVIEAAVRDAEKNAALNGITNAHYVADSAENAMANWCQEGIKPTVIIVDPPRKGLTESFIKASAAMQP
DKITYISCNPATMARDIKRYEELGYKLQKVQPVDLFPMTHHVECVVLLQRSKG
>Mature_453_residues
MLSKNDIVQVEISDLSHDGLGIAKHEGFVFFVENALPGEIIQMRVLKVNKNSGFGKVETYLTTSPMRQKKLDVTYLRTGI
ADLGHLLYPQQLLFKQKQVQDSLYKIAGISNVEVKETIGMEYPYAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDFY
IQDKEIDRLIAFTRDLLRRFDIKPYDEKEQSGLIRHLVVRRGHYSGEIMLVLVTTRPKIFRINQMIDRLVAEFPAITSIL
QNINDKPTNVIFGKAFTRLYGKETITDTILGNQYCISAQSFYQVNTTMAEKLYQTAIDFSELTADDVVIDAYSGIGTIGL
SFAKEVKAVYGVEVIEAAVRDAEKNAALNGITNAHYVADSAENAMANWCQEGIKPTVIIVDPPRKGLTESFIKASAAMQP
DKITYISCNPATMARDIKRYEELGYKLQKVQPVDLFPMTHHVECVVLLQRSKG

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=208, Percent_Identity=35.5769230769231, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI51173878, Length=208, Percent_Identity=35.5769230769231, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI269784678, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI269784680, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI269784676, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI20149688, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1789148, Length=462, Percent_Identity=25.5411255411255, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1787083, Length=328, Percent_Identity=26.8292682926829, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790403, Length=184, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997438, Length=513, Percent_Identity=22.0272904483431, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322909, Length=444, Percent_Identity=24.0990990990991, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666579, Length=417, Percent_Identity=30.2158273381295, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51173; Mature: 51173

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKNDIVQVEISDLSHDGLGIAKHEGFVFFVENALPGEIIQMRVLKVNKNSGFGKVETY
CCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCEEEEEEEEEECCCCCCEEEEE
LTTSPMRQKKLDVTYLRTGIADLGHLLYPQQLLFKQKQVQDSLYKIAGISNVEVKETIGM
EECCCHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
EYPYAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDFYIQDKEIDRLIAFTRDLLRRF
CCCHHHCCCCCCCHHHHCCCCCCCHHHHCCCCEEECHHHEECHHHHHHHHHHHHHHHHHC
DIKPYDEKEQSGLIRHLVVRRGHYSGEIMLVLVTTRPKIFRINQMIDRLVAEFPAITSIL
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
QNINDKPTNVIFGKAFTRLYGKETITDTILGNQYCISAQSFYQVNTTMAEKLYQTAIDFS
HCCCCCCCEEEEHHHHHHHHCCHHHHHHHCCCCEEECCHHHEEHHHHHHHHHHHHHHCHH
ELTADDVVIDAYSGIGTIGLSFAKEVKAVYGVEVIEAAVRDAEKNAALNGITNAHYVADS
HCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEECCC
AENAMANWCQEGIKPTVIIVDPPRKGLTESFIKASAAMQPDKITYISCNPATMARDIKRY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHH
EELGYKLQKVQPVDLFPMTHHVECVVLLQRSKG
HHHCCEECCCCCCEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MLSKNDIVQVEISDLSHDGLGIAKHEGFVFFVENALPGEIIQMRVLKVNKNSGFGKVETY
CCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCEEEEEEEEEECCCCCCEEEEE
LTTSPMRQKKLDVTYLRTGIADLGHLLYPQQLLFKQKQVQDSLYKIAGISNVEVKETIGM
EECCCHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
EYPYAYRNKAQVPVRRVNGQLETGFFRKHSHELVPISDFYIQDKEIDRLIAFTRDLLRRF
CCCHHHCCCCCCCHHHHCCCCCCCHHHHCCCCEEECHHHEECHHHHHHHHHHHHHHHHHC
DIKPYDEKEQSGLIRHLVVRRGHYSGEIMLVLVTTRPKIFRINQMIDRLVAEFPAITSIL
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
QNINDKPTNVIFGKAFTRLYGKETITDTILGNQYCISAQSFYQVNTTMAEKLYQTAIDFS
HCCCCCCCEEEEHHHHHHHHCCHHHHHHHCCCCEEECCHHHEEHHHHHHHHHHHHHHCHH
ELTADDVVIDAYSGIGTIGLSFAKEVKAVYGVEVIEAAVRDAEKNAALNGITNAHYVADS
HCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEECCC
AENAMANWCQEGIKPTVIIVDPPRKGLTESFIKASAAMQPDKITYISCNPATMARDIKRY
HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHH
EELGYKLQKVQPVDLFPMTHHVECVVLLQRSKG
HHHCCEECCCCCCEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345 [H]