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The map label for this gene is hpt [H]

Identifier: 195977169

GI number: 195977169

Start: 13915

End: 14457

Strand: Direct

Name: hpt [H]

Synonym: Sez_0013

Alternate gene names: 195977169

Gene position: 13915-14457 (Clockwise)

Preceding gene: 195977168

Following gene: 195977170

Centisome position: 0.69

GC content: 36.83

Gene sequence:

>543_bases
ATGCTTGAGCAAGATATTCAAAAAATTCTTTATTCTGAAAATGACATTATTCAAAGGACCAAGGAGCTTGGTGAGCAGTT
GACAAAGGATTATCATGGTAAAAATCCCTTGATGGTCGGTGTCTTAAAGGGCTCTGTTCCATTCATGGCCGAGCTGATGA
AGCACATTGACACTCACGTTGAAATTGATTTTATGGTTGTTTCTAGCTATAATGGTGGAACAACTAGCAGTGGAGAGGTT
AAAATTTTAAAAGACGTTGACACCAATATTGAGGGAAGAGATGTCATCTTTGTTGAAGATATTATTGATACTGGTCGAAC
ACTCAAATATTTACGTGACATGTTCAAATATCGTAAGGCTAATTCCGTTAAGATTATCACACTATTTGACAAGCCAGAGG
GTCGTGTGGTAGACATTGAGGCAGACTATGTGTGTTACAATGTTCCTAATGAGTTTATTGTAGGCTTCGGATTAGATTAC
GCAGAAAATTATAGAAATCTCCCTTATGTCGGTGTTTTAAAAGAGGAAGTCTATTCAAAATAG

Upstream 100 bases:

>100_bases
TTTGTGCTGGTTGGCGATGAAACATATTTGAGAAAAGCGTCTAAACATGATATAATGTTGGCTAAACTGTATATTGATAA
ATTAGAAAAAAGGTGACAGT

Downstream 100 bases:

>100_bases
GAAAAGGTCAATTATTGTTGTATGAAAAATAATAAAAATAATGGATTTGTCAAAAATTCTTTTATATATATATTGATGAT
TGTTATTGTTGTAGCAGGAT

Product: hypoxanthine-guanine phosphoribosyltransferase protein Hpt

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLEQDIQKILYSENDIIQRTKELGEQLTKDYHGKNPLMVGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYNGGTTSSGEV
KILKDVDTNIEGRDVIFVEDIIDTGRTLKYLRDMFKYRKANSVKIITLFDKPEGRVVDIEADYVCYNVPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK

Sequences:

>Translated_180_residues
MLEQDIQKILYSENDIIQRTKELGEQLTKDYHGKNPLMVGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYNGGTTSSGEV
KILKDVDTNIEGRDVIFVEDIIDTGRTLKYLRDMFKYRKANSVKIITLFDKPEGRVVDIEADYVCYNVPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK
>Mature_180_residues
MLEQDIQKILYSENDIIQRTKELGEQLTKDYHGKNPLMVGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYNGGTTSSGEV
KILKDVDTNIEGRDVIFVEDIIDTGRTLKYLRDMFKYRKANSVKIITLFDKPEGRVVDIEADYVCYNVPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=187, Percent_Identity=30.4812834224599, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI9910262, Length=182, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=43.9759036144578, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=30.3370786516854, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20647; Mature: 20647

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQDIQKILYSENDIIQRTKELGEQLTKDYHGKNPLMVGVLKGSVPFMAELMKHIDTHV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCE
EIDFMVVSSYNGGTTSSGEVKILKDVDTNIEGRDVIFVEDIIDTGRTLKYLRDMFKYRKA
EEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC
NSVKIITLFDKPEGRVVDIEADYVCYNVPNEFIVGFGLDYAENYRNLPYVGVLKEEVYSK
CCEEEEEEEECCCCEEEEEECCEEEEECCCCEEEECCCCHHHHCCCCCEEEHHHHHHCCC
>Mature Secondary Structure
MLEQDIQKILYSENDIIQRTKELGEQLTKDYHGKNPLMVGVLKGSVPFMAELMKHIDTHV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCE
EIDFMVVSSYNGGTTSSGEVKILKDVDTNIEGRDVIFVEDIIDTGRTLKYLRDMFKYRKA
EEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC
NSVKIITLFDKPEGRVVDIEADYVCYNVPNEFIVGFGLDYAENYRNLPYVGVLKEEVYSK
CCEEEEEEEECCCCEEEEEECCEEEEECCCCEEEECCCCHHHHCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]