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The map label for this gene is hisG

Identifier: 195953007

GI number: 195953007

Start: 565348

End: 565962

Strand: Direct

Name: hisG

Synonym: HY04AAS1_0632

Alternate gene names: 195953007

Gene position: 565348-565962 (Clockwise)

Preceding gene: 195953006

Following gene: 195953008

Centisome position: 36.25

GC content: 31.22

Gene sequence:

>615_bases
ATGCTTAAAATAGCAATACCAAAAGGAAGACTGCTAGAAGAAGTATCGGAATTATTTCTTAGTAAAAGCCTGATACCTAG
CAAAATTGAAGAAAGCAGAAAGCTGATAGTTGATATAGATTACTTCAGATTTTTAATAGTAAAACCATCGGATGTAGCGA
CATATGTAGAGCAAGGAGCGGCAGATATAGGAGTGGTGGGATTAGATGTGTTAAAAGAAGAACCAAAAGAGATATATGAA
ATTTTAGATTTGAAAAACATAGGTAAATGTAGTATGGTAGTGGCCGGAAAGCCAGAAAAACTTGGAGACTACAAAATACT
TCATTTTACAAAAGTTGCTACAAAGTATGTAAATATAGCCAGGAGCTTCTTTGAAGGTAAAGACGTTTCTATAAACATTA
TAAAATTAAACGGTTCAGTAGAAATAGCTCCCATAATAGGACTAAGCGATTATATAGTTGATATAACTCAAACGGGGAAG
ACCTTAAAAGAAAATGGTCTCATAGTGATGGAAAAAATATTCGATTCACATGCAAAGATAATATGTAACAAAGTAGCTTT
TAGAATAAAAAAATATGATATATTTAAAATATTGGATAAATTATCCGATATTTAG

Upstream 100 bases:

>100_bases
ATAAAAAGCACCATAGACGGACAAGTAGAGGAAATTCTGGTAGAAATAGGAGAGGTTATAAATCCCGGTGAAGTGCTCAT
AAGGCTAAAACCAGAATTTG

Downstream 100 bases:

>100_bases
GTGTAGTGTATGGACATATTCTCTATTATAGGTTTTTTGGCTTTTGGTTCACTTTTGTTAGGAGCTTTTTTAGATGGGAC
TCATCTTGCAATTTTAATAC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGAADIGVVGLDVLKEEPKEIYE
ILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIARSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGK
TLKENGLIVMEKIFDSHAKIICNKVAFRIKKYDIFKILDKLSDI

Sequences:

>Translated_204_residues
MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGAADIGVVGLDVLKEEPKEIYE
ILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIARSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGK
TLKENGLIVMEKIFDSHAKIICNKVAFRIKKYDIFKILDKLSDI
>Mature_204_residues
MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGAADIGVVGLDVLKEEPKEIYE
ILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIARSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGK
TLKENGLIVMEKIFDSHAKIICNKVAFRIKKYDIFKILDKLSDI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=196, Percent_Identity=32.6530612244898, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320896, Length=146, Percent_Identity=30.1369863013699, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_HYDS0 (B4U858)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121297.1
- ProteinModelPortal:   B4U858
- SMR:   B4U858
- GeneID:   6743431
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0632
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22908; Mature: 22908

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGA
CEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEEEEEEEECCCHHHHHHHCCC
ADIGVVGLDVLKEEPKEIYEILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIA
CCEEHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHH
RSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGKTLKENGLIVMEKIFDSHAKI
HHHHCCCCCEEEEEEECCCEEEEEEECCHHHEEEHHHCCCHHHHCCCEEEHHHHHHHHHH
ICNKVAFRIKKYDIFKILDKLSDI
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKIAIPKGRLLEEVSELFLSKSLIPSKIEESRKLIVDIDYFRFLIVKPSDVATYVEQGA
CEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEEEEEEEECCCHHHHHHHCCC
ADIGVVGLDVLKEEPKEIYEILDLKNIGKCSMVVAGKPEKLGDYKILHFTKVATKYVNIA
CCEEHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHH
RSFFEGKDVSINIIKLNGSVEIAPIIGLSDYIVDITQTGKTLKENGLIVMEKIFDSHAKI
HHHHCCCCCEEEEEEECCCEEEEEEECCHHHEEEHHHCCCHHHHCCCEEEHHHHHHHHHH
ICNKVAFRIKKYDIFKILDKLSDI
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA