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The map label for this gene is lon [H]

Identifier: 195952935

GI number: 195952935

Start: 495689

End: 498112

Strand: Direct

Name: lon [H]

Synonym: HY04AAS1_0560

Alternate gene names: 195952935

Gene position: 495689-498112 (Clockwise)

Preceding gene: 195952934

Following gene: 195952936

Centisome position: 31.78

GC content: 35.4

Gene sequence:

>2424_bases
ATGGATTTAGAAACCCAAAACATTTACGTAAATCAAGAAATTCAAAAGTTAAATTTGATGCCGCTAAGAGATATTATAGT
ATTTCCCGGAATGGTTATACCACTTTTTGTAGGAAGGCCTTTTTCTGTAAGAGCTATAGAAGATGCTTTTAAACATAATA
AGCTTATGTTTTTTGTACTACAAAAAGATAGAGACCAAGAAGAGCCAAAGTCTCTTAACGAGCTATATAAAATAGGTACT
ATAGTTAAAATACTAAGGGCAGTTCCTCTGGAAGATGGTAGACTTAAGATACTGGCCCAAGGTTTAGAAAAGGGCGAGCT
CAAAGCTTTAGAAAAAGTAAACAACATTTATGTTGCAGATGTTTTGCCGATCAAAGAAGAAATAATAAAAATAGATGATT
TACCACCAAAAGAAAAGGCTTATGTAAATTCTATAAAAGATTTAATAGAAAAGGCTGTCAATTTGGGTAAGCAAATAATA
CCTGATTTTGTAGGGATAGTTAGGGAAACCGAAGAGTTAGATAAATTTTTAGATCTTGTCGCTTCTATACTTGATTTAAA
AGCCCAAGATGCTCAAAGCATATTAGAGATTACAGATCTTAAGAAAAAGCTTGTCAAAATCCATGATTTGCTCCTTTCGG
AAGTGGGCATATTGGAGTTGCAAAATCGAATAAAAAATAGTGCCAGAGAAAAAATGGAAAAGGAGCAAAAAGAATACTAT
TTAAGACAGCAGATGAAAGCAATACAAGAAGAGCTTGGGGAAAGCGACGATAGACAAGCAGAGGTAAAAGAATATTTAGA
GAAATTAAAAAAATTAAAAGTGCCAAAATCTGTAAAAGAAGATATAGAAAAACAGATAAATAGATTATCAAAGATGTATC
CAGAATCAGCAGAGAGCACAGTTATAAGGACATGGCTTGATTGGATTTTTGAACTTCCTTGGAACAAAAAAACAAAAGAT
ATCTTTGATATAGAAAAAGCTCAAAAACTTTTGGATAAAGACCATTACGATTTAGAAAAGATAAAAGAGCGTATAATAGA
ATACTTATCTGTCAGAAAACTTACAAAGGGTAAGGGCTCTAAGTCTACAATACTTTGTTTTATTGGACCACCAGGGGTTG
GAAAAACATCCTTGGGGCAATCTATAGCAAAAGCTACAGGAAGAAAATTTGTAAGGATTTCTTTAGGTGGCATAAGAGAT
GAAGCAGAAATAAGAGGCCATAGGCGAACATACGTAGGGGCTATGCCAGGGCGCATAATTCAAGCCATAAAGCAAGCTGG
CGTTAAAAATCCTCTTATCATGCTTGATGAGATAGACAAGCTGTCTGTGTCTTTCCAGGGAGATCCAGCGGCAGCTCTTT
TAGAGGTGTTGGATCCAGAACAAAATAAGTCTTTTACGGATCTTTACATAGGGCATCCTTTTGATCTTTCGGAAGTGCTT
TTTGTAGCAACTGGCAATAGAGTAGATACTATACCACAACCTCTTTTAGATAGAATGGAAGTGCTTTATCTTTCCGGGTA
TTCTGAAGAAGAAAAGCTTCATATAGCGAAAAATCATTTGTTACCCGCCATCATAAAAGATCACGGCTTTAAAGAATCGG
AAATAAACATAGAAGATGAAGCTATATTAGAAGTTATTAGGAGTTATACAAGAGAGGCAGGTGTTAGAAACCTCAAACAA
AAGTTGGCATCTTTATTGAGAAAATTGGCTGTTAAAAAACTAAAAGGTCAAAAACCGCCTTTTGTAATAAATAAAACTGC
CATTAAAGAACTCCTTGGCGTACCTCGTATTATCAGAGAAAAAGAAGAATTAGAACAAGCTATTGGTCTTGTTACTGGTC
TTGCCTGGACCGAAGTAGGCGGTGAAATAATGTATATAGAGGTTACAAAATTAAAAGGCAAAGGAGCTCTTATATTGACC
GGTTCTTTAGGTGATGTTATGAAAGAATCTGCCCAAGCTGCTCTTTCTTATATAAAATCAAAGGCAGATCAGTATGGAAT
AGATAGCTCCTTGTTTACAAAATACGATGTACATATACACGTTCCAGAAGGTGCTGTACCAAAAGACGGCCCATCGGCTG
GCATTGCTATAGCTACTGGTATATTGTCGATATTTACAGAAAAGCCAGTAAGACTTGACGTAGCTATGACGGGCGAGGTT
ACTTTAAGAGGAAGGGTCTTACCCATAGGTGGTGTTAAAGAAAAGATTCTTGCTGCAAAAAGAGCCGGTATATATGAAGT
GATACTACCATCAAAAAACAAAGTTGAAGTAATGGAAGATTTGCCAGATTATGTGAAAGAAAAAATGCAATTTCACTTTG
TAGACCATCTAGATGAAGTGTTTAAAATTGTTTTTAAGGATAACATTGTAAAGCAGAAGCCTAAAAAAGGCTCCAAACCC
AAAAAAGCTAAGGAGAAGCCTTGA

Upstream 100 bases:

>100_bases
TATGATGCCTCATCCTGAGCGTATATCCGAAGATATTTTAGGTGGTTTGGATGGCCTAAAAATTTGGCATTCTCTTATAG
CCTAACTTAAAGGAGGCAAT

Downstream 100 bases:

>100_bases
TATTAAGCGATAAAACCATATTGGACTACATAAAGAGCTCAAAAATTATAGTAGAGCCTTTTGATGAATCTTCTTTGCAA
TGCTCTTCTTTGGATCTAAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MDLETQNIYVNQEIQKLNLMPLRDIIVFPGMVIPLFVGRPFSVRAIEDAFKHNKLMFFVLQKDRDQEEPKSLNELYKIGT
IVKILRAVPLEDGRLKILAQGLEKGELKALEKVNNIYVADVLPIKEEIIKIDDLPPKEKAYVNSIKDLIEKAVNLGKQII
PDFVGIVRETEELDKFLDLVASILDLKAQDAQSILEITDLKKKLVKIHDLLLSEVGILELQNRIKNSAREKMEKEQKEYY
LRQQMKAIQEELGESDDRQAEVKEYLEKLKKLKVPKSVKEDIEKQINRLSKMYPESAESTVIRTWLDWIFELPWNKKTKD
IFDIEKAQKLLDKDHYDLEKIKERIIEYLSVRKLTKGKGSKSTILCFIGPPGVGKTSLGQSIAKATGRKFVRISLGGIRD
EAEIRGHRRTYVGAMPGRIIQAIKQAGVKNPLIMLDEIDKLSVSFQGDPAAALLEVLDPEQNKSFTDLYIGHPFDLSEVL
FVATGNRVDTIPQPLLDRMEVLYLSGYSEEEKLHIAKNHLLPAIIKDHGFKESEINIEDEAILEVIRSYTREAGVRNLKQ
KLASLLRKLAVKKLKGQKPPFVINKTAIKELLGVPRIIREKEELEQAIGLVTGLAWTEVGGEIMYIEVTKLKGKGALILT
GSLGDVMKESAQAALSYIKSKADQYGIDSSLFTKYDVHIHVPEGAVPKDGPSAGIAIATGILSIFTEKPVRLDVAMTGEV
TLRGRVLPIGGVKEKILAAKRAGIYEVILPSKNKVEVMEDLPDYVKEKMQFHFVDHLDEVFKIVFKDNIVKQKPKKGSKP
KKAKEKP

Sequences:

>Translated_807_residues
MDLETQNIYVNQEIQKLNLMPLRDIIVFPGMVIPLFVGRPFSVRAIEDAFKHNKLMFFVLQKDRDQEEPKSLNELYKIGT
IVKILRAVPLEDGRLKILAQGLEKGELKALEKVNNIYVADVLPIKEEIIKIDDLPPKEKAYVNSIKDLIEKAVNLGKQII
PDFVGIVRETEELDKFLDLVASILDLKAQDAQSILEITDLKKKLVKIHDLLLSEVGILELQNRIKNSAREKMEKEQKEYY
LRQQMKAIQEELGESDDRQAEVKEYLEKLKKLKVPKSVKEDIEKQINRLSKMYPESAESTVIRTWLDWIFELPWNKKTKD
IFDIEKAQKLLDKDHYDLEKIKERIIEYLSVRKLTKGKGSKSTILCFIGPPGVGKTSLGQSIAKATGRKFVRISLGGIRD
EAEIRGHRRTYVGAMPGRIIQAIKQAGVKNPLIMLDEIDKLSVSFQGDPAAALLEVLDPEQNKSFTDLYIGHPFDLSEVL
FVATGNRVDTIPQPLLDRMEVLYLSGYSEEEKLHIAKNHLLPAIIKDHGFKESEINIEDEAILEVIRSYTREAGVRNLKQ
KLASLLRKLAVKKLKGQKPPFVINKTAIKELLGVPRIIREKEELEQAIGLVTGLAWTEVGGEIMYIEVTKLKGKGALILT
GSLGDVMKESAQAALSYIKSKADQYGIDSSLFTKYDVHIHVPEGAVPKDGPSAGIAIATGILSIFTEKPVRLDVAMTGEV
TLRGRVLPIGGVKEKILAAKRAGIYEVILPSKNKVEVMEDLPDYVKEKMQFHFVDHLDEVFKIVFKDNIVKQKPKKGSKP
KKAKEKP
>Mature_807_residues
MDLETQNIYVNQEIQKLNLMPLRDIIVFPGMVIPLFVGRPFSVRAIEDAFKHNKLMFFVLQKDRDQEEPKSLNELYKIGT
IVKILRAVPLEDGRLKILAQGLEKGELKALEKVNNIYVADVLPIKEEIIKIDDLPPKEKAYVNSIKDLIEKAVNLGKQII
PDFVGIVRETEELDKFLDLVASILDLKAQDAQSILEITDLKKKLVKIHDLLLSEVGILELQNRIKNSAREKMEKEQKEYY
LRQQMKAIQEELGESDDRQAEVKEYLEKLKKLKVPKSVKEDIEKQINRLSKMYPESAESTVIRTWLDWIFELPWNKKTKD
IFDIEKAQKLLDKDHYDLEKIKERIIEYLSVRKLTKGKGSKSTILCFIGPPGVGKTSLGQSIAKATGRKFVRISLGGIRD
EAEIRGHRRTYVGAMPGRIIQAIKQAGVKNPLIMLDEIDKLSVSFQGDPAAALLEVLDPEQNKSFTDLYIGHPFDLSEVL
FVATGNRVDTIPQPLLDRMEVLYLSGYSEEEKLHIAKNHLLPAIIKDHGFKESEINIEDEAILEVIRSYTREAGVRNLKQ
KLASLLRKLAVKKLKGQKPPFVINKTAIKELLGVPRIIREKEELEQAIGLVTGLAWTEVGGEIMYIEVTKLKGKGALILT
GSLGDVMKESAQAALSYIKSKADQYGIDSSLFTKYDVHIHVPEGAVPKDGPSAGIAIATGILSIFTEKPVRLDVAMTGEV
TLRGRVLPIGGVKEKILAAKRAGIYEVILPSKNKVEVMEDLPDYVKEKMQFHFVDHLDEVFKIVFKDNIVKQKPKKGSKP
KKAKEKP

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=42.6966292134831, Blast_Score=534, Evalue=1e-151,
Organism=Homo sapiens, GI31377667, Length=574, Percent_Identity=46.8641114982578, Blast_Score=529, Evalue=1e-150,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=48.2535575679172, Blast_Score=728, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=694, Percent_Identity=38.6167146974063, Blast_Score=484, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=513, Percent_Identity=41.7153996101365, Blast_Score=434, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=677, Percent_Identity=40.9158050221566, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=639, Percent_Identity=43.8184663536776, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221513036, Length=639, Percent_Identity=43.8184663536776, Blast_Score=543, Evalue=1e-154,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 91187; Mature: 91187

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLETQNIYVNQEIQKLNLMPLRDIIVFPGMVIPLFVGRPFSVRAIEDAFKHNKLMFFVL
CCCCCCEEEECCHHHHCCCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEE
QKDRDQEEPKSLNELYKIGTIVKILRAVPLEDGRLKILAQGLEKGELKALEKVNNIYVAD
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCEEEEE
VLPIKEEIIKIDDLPPKEKAYVNSIKDLIEKAVNLGKQIIPDFVGIVRETEELDKFLDLV
EHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASILDLKAQDAQSILEITDLKKKLVKIHDLLLSEVGILELQNRIKNSAREKMEKEQKEYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQQMKAIQEELGESDDRQAEVKEYLEKLKKLKVPKSVKEDIEKQINRLSKMYPESAEST
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VIRTWLDWIFELPWNKKTKDIFDIEKAQKLLDKDHYDLEKIKERIIEYLSVRKLTKGKGS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
KSTILCFIGPPGVGKTSLGQSIAKATGRKFVRISLGGIRDEAEIRGHRRTYVGAMPGRII
CCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHH
QAIKQAGVKNPLIMLDEIDKLSVSFQGDPAAALLEVLDPEQNKSFTDLYIGHPFDLSEVL
HHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHEE
FVATGNRVDTIPQPLLDRMEVLYLSGYSEEEKLHIAKNHLLPAIIKDHGFKESEINIEDE
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
AILEVIRSYTREAGVRNLKQKLASLLRKLAVKKLKGQKPPFVINKTAIKELLGVPRIIRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCHHHHHH
KEELEQAIGLVTGLAWTEVGGEIMYIEVTKLKGKGALILTGSLGDVMKESAQAALSYIKS
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
KADQYGIDSSLFTKYDVHIHVPEGAVPKDGPSAGIAIATGILSIFTEKPVRLDVAMTGEV
HHHHCCCCCHHEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCE
TLRGRVLPIGGVKEKILAAKRAGIYEVILPSKNKVEVMEDLPDYVKEKMQFHFVDHLDEV
EEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FKIVFKDNIVKQKPKKGSKPKKAKEKP
HHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLETQNIYVNQEIQKLNLMPLRDIIVFPGMVIPLFVGRPFSVRAIEDAFKHNKLMFFVL
CCCCCCEEEECCHHHHCCCCCHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEE
QKDRDQEEPKSLNELYKIGTIVKILRAVPLEDGRLKILAQGLEKGELKALEKVNNIYVAD
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCEEEEE
VLPIKEEIIKIDDLPPKEKAYVNSIKDLIEKAVNLGKQIIPDFVGIVRETEELDKFLDLV
EHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASILDLKAQDAQSILEITDLKKKLVKIHDLLLSEVGILELQNRIKNSAREKMEKEQKEYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQQMKAIQEELGESDDRQAEVKEYLEKLKKLKVPKSVKEDIEKQINRLSKMYPESAEST
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VIRTWLDWIFELPWNKKTKDIFDIEKAQKLLDKDHYDLEKIKERIIEYLSVRKLTKGKGS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
KSTILCFIGPPGVGKTSLGQSIAKATGRKFVRISLGGIRDEAEIRGHRRTYVGAMPGRII
CCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHH
QAIKQAGVKNPLIMLDEIDKLSVSFQGDPAAALLEVLDPEQNKSFTDLYIGHPFDLSEVL
HHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHEE
FVATGNRVDTIPQPLLDRMEVLYLSGYSEEEKLHIAKNHLLPAIIKDHGFKESEINIEDE
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
AILEVIRSYTREAGVRNLKQKLASLLRKLAVKKLKGQKPPFVINKTAIKELLGVPRIIRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCHHHHHH
KEELEQAIGLVTGLAWTEVGGEIMYIEVTKLKGKGALILTGSLGDVMKESAQAALSYIKS
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
KADQYGIDSSLFTKYDVHIHVPEGAVPKDGPSAGIAIATGILSIFTEKPVRLDVAMTGEV
HHHHCCCCCHHEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCE
TLRGRVLPIGGVKEKILAAKRAGIYEVILPSKNKVEVMEDLPDYVKEKMQFHFVDHLDEV
EEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FKIVFKDNIVKQKPKKGSKPKKAKEKP
HHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]