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The map label for this gene is ahcY [H]

Identifier: 195952899

GI number: 195952899

Start: 461062

End: 462327

Strand: Direct

Name: ahcY [H]

Synonym: HY04AAS1_0524

Alternate gene names: 195952899

Gene position: 461062-462327 (Clockwise)

Preceding gene: 195952898

Following gene: 195952900

Centisome position: 29.56

GC content: 36.41

Gene sequence:

>1266_bases
TTGAATTACGATATAAAAGATATTAATTTGGCTAAGCAAGGAAAAGATAGAATTGAATGGGCTGGTATTGATATGCCTGT
ATTAAAATCTATAAGAGAAGAGTTTGCTAAGACAAAACCTTTTCACGGCATAACCATAGGAGCTTGTCTTCATGTAACTA
CAGAAACAGCAAATCTTATGATAACATTAAAAGAAGGGGGAGCAAACGTATATCTTTGTGCTTCAAACCCGCTTTCAACT
CAAGACGATGTAGCCGCTTCATTGGTAAAAGATTATGACATACCTGTATTTGCAATAAAGGGCGAGGATAACAATACATT
TTATAAGCATTTAAGAAGCATCCTAGATAAAAATCCAAATATATTGATAGACGATGGAGCTGATTTGATTTCTACTGCTC
ACAAAGAATACGAAGAGCTAACCAAAAAGATTTTTGGAGCAATGGAAGAAACAACTACAGGTGTTATAAGGCTAAAAGCT
ATGGCAAAAGATAAGGCTCTTAAATTTCCAGTTATAGCAGTAAATGATGCTCTTACCAAGCATATGTTTGATAACAGATA
TGGCACAGGACAATCTACGCTAGATGGTATATTAAGAGCTACAAATCGTCTCATAGCAGGTTCTACTTTTGTAGTAGCAG
GCTACGGCTGGTGCGGTAAAGGTGTAGCTATGAGAGCAAGAGGCATGGGCGCTAATGTTATAGTTACAGAAGTAGACCCT
TTAAAAGCGTTAGAAGCTAGGATGGATGGTTTTTTGGTTATGCCAATGGAAAAAGCAGCTCCATTGGGAGATATATTTGT
AACCGTAACAGGAAATACAAAAGTGATAAGGCAAGAGCATTTTGAAGTAATAAAAAACGGAGCTATCGTATCAAACTCAG
GACATTTTGACGTAGAGATAGATGTCAGATATTTAGAAAGCGTTGCATTAGAAATAAACGAAAGAAGGCCTATGGTTAAA
GAATATATTATCAATACTAAAAGCGGTAAAAAACGTATATACGTGTTGGCAGAAGGAAGGCTTGTAAACTTAGCGGCAGC
AGAAGGTCATCCAGCTTCTGTTATGGATATGTCTTTTGCCAATCAAGCACTATCAGCAGAATTTATTTTAAATAATCATA
GCAAATTAGAAAAAGATGTGTATAAAGTGCCAGACGACATAGACCAAAAAGTAGCTAAACTAAAGCTTGATTCCATGGGC
ATAGAGATTGACATACTCACACCAGAACAGATAGCTTATATGTCCTCTTGGGAACATGGCACATAA

Upstream 100 bases:

>100_bases
ACAGAATTATTACAGACAAAATATAATGTTGTAGAGGTATCTTGTCAAGCTCAAGGACATGAAAAATGCACCTTCAAAAT
AAAAAAGGAGGCCAAATAAT

Downstream 100 bases:

>100_bases
TCTCTAATGATTAAAACCCTTGACTTGCTTAAGATTTAAGTTATTATCTAATACATGGAAAAAAAATTAAAAAAACTTAA
AGATGCTTTGGGCGATAAAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNYDIKDINLAKQGKDRIEWAGIDMPVLKSIREEFAKTKPFHGITIGACLHVTTETANLMITLKEGGANVYLCASNPLST
QDDVAASLVKDYDIPVFAIKGEDNNTFYKHLRSILDKNPNILIDDGADLISTAHKEYEELTKKIFGAMEETTTGVIRLKA
MAKDKALKFPVIAVNDALTKHMFDNRYGTGQSTLDGILRATNRLIAGSTFVVAGYGWCGKGVAMRARGMGANVIVTEVDP
LKALEARMDGFLVMPMEKAAPLGDIFVTVTGNTKVIRQEHFEVIKNGAIVSNSGHFDVEIDVRYLESVALEINERRPMVK
EYIINTKSGKKRIYVLAEGRLVNLAAAEGHPASVMDMSFANQALSAEFILNNHSKLEKDVYKVPDDIDQKVAKLKLDSMG
IEIDILTPEQIAYMSSWEHGT

Sequences:

>Translated_421_residues
MNYDIKDINLAKQGKDRIEWAGIDMPVLKSIREEFAKTKPFHGITIGACLHVTTETANLMITLKEGGANVYLCASNPLST
QDDVAASLVKDYDIPVFAIKGEDNNTFYKHLRSILDKNPNILIDDGADLISTAHKEYEELTKKIFGAMEETTTGVIRLKA
MAKDKALKFPVIAVNDALTKHMFDNRYGTGQSTLDGILRATNRLIAGSTFVVAGYGWCGKGVAMRARGMGANVIVTEVDP
LKALEARMDGFLVMPMEKAAPLGDIFVTVTGNTKVIRQEHFEVIKNGAIVSNSGHFDVEIDVRYLESVALEINERRPMVK
EYIINTKSGKKRIYVLAEGRLVNLAAAEGHPASVMDMSFANQALSAEFILNNHSKLEKDVYKVPDDIDQKVAKLKLDSMG
IEIDILTPEQIAYMSSWEHGT
>Mature_421_residues
MNYDIKDINLAKQGKDRIEWAGIDMPVLKSIREEFAKTKPFHGITIGACLHVTTETANLMITLKEGGANVYLCASNPLST
QDDVAASLVKDYDIPVFAIKGEDNNTFYKHLRSILDKNPNILIDDGADLISTAHKEYEELTKKIFGAMEETTTGVIRLKA
MAKDKALKFPVIAVNDALTKHMFDNRYGTGQSTLDGILRATNRLIAGSTFVVAGYGWCGKGVAMRARGMGANVIVTEVDP
LKALEARMDGFLVMPMEKAAPLGDIFVTVTGNTKVIRQEHFEVIKNGAIVSNSGHFDVEIDVRYLESVALEINERRPMVK
EYIINTKSGKKRIYVLAEGRLVNLAAAEGHPASVMDMSFANQALSAEFILNNHSKLEKDVYKVPDDIDQKVAKLKLDSMG
IEIDILTPEQIAYMSSWEHGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=418, Percent_Identity=43.7799043062201, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI239937451, Length=394, Percent_Identity=44.6700507614213, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI195539349, Length=417, Percent_Identity=38.3693045563549, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI298286489, Length=417, Percent_Identity=38.3693045563549, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI195539337, Length=417, Percent_Identity=38.3693045563549, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI24308043, Length=417, Percent_Identity=38.3693045563549, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI21361647, Length=417, Percent_Identity=37.8896882494005, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17506425, Length=421, Percent_Identity=41.5676959619952, Blast_Score=304, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6320882, Length=438, Percent_Identity=42.4657534246575, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24642172, Length=423, Percent_Identity=42.5531914893617, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24656245, Length=405, Percent_Identity=38.5185185185185, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI45553385, Length=416, Percent_Identity=37.7403846153846, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI45553387, Length=416, Percent_Identity=37.7403846153846, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46473; Mature: 46473

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDIKDINLAKQGKDRIEWAGIDMPVLKSIREEFAKTKPFHGITIGACLHVTTETANLM
CCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCEEE
ITLKEGGANVYLCASNPLSTQDDVAASLVKDYDIPVFAIKGEDNNTFYKHLRSILDKNPN
EEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
ILIDDGADLISTAHKEYEELTKKIFGAMEETTTGVIRLKAMAKDKALKFPVIAVNDALTK
EEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEECCCCCEECCEEEECHHHHH
HMFDNRYGTGQSTLDGILRATNRLIAGSTFVVAGYGWCGKGVAMRARGMGANVIVTEVDP
HHHCCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEECCCCCEEEEECCCH
LKALEARMDGFLVMPMEKAAPLGDIFVTVTGNTKVIRQEHFEVIKNGAIVSNSGHFDVEI
HHHHHHHCCCEEEEEHHHCCCCCEEEEEEECCCEEHHHHHHHHHHCCEEEECCCCEEEEE
DVRYLESVALEINERRPMVKEYIINTKSGKKRIYVLAEGRLVNLAAAEGHPASVMDMSFA
EHHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEEEECCEEEEEEECCCCCCCEEEHHHH
NQALSAEFILNNHSKLEKDVYKVPDDIDQKVAKLKLDSMGIEIDILTPEQIAYMSSWEHG
HHHHEEEEEECCCHHHHHHHHCCCCHHHHHHHHEEHHHCCEEEEEECHHHHHHHCCCCCC
T
C
>Mature Secondary Structure
MNYDIKDINLAKQGKDRIEWAGIDMPVLKSIREEFAKTKPFHGITIGACLHVTTETANLM
CCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCEEE
ITLKEGGANVYLCASNPLSTQDDVAASLVKDYDIPVFAIKGEDNNTFYKHLRSILDKNPN
EEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCC
ILIDDGADLISTAHKEYEELTKKIFGAMEETTTGVIRLKAMAKDKALKFPVIAVNDALTK
EEEECCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEEECCCCCEECCEEEECHHHHH
HMFDNRYGTGQSTLDGILRATNRLIAGSTFVVAGYGWCGKGVAMRARGMGANVIVTEVDP
HHHCCCCCCCHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEECCCCCEEEEECCCH
LKALEARMDGFLVMPMEKAAPLGDIFVTVTGNTKVIRQEHFEVIKNGAIVSNSGHFDVEI
HHHHHHHCCCEEEEEHHHCCCCCEEEEEEECCCEEHHHHHHHHHHCCEEEECCCCEEEEE
DVRYLESVALEINERRPMVKEYIINTKSGKKRIYVLAEGRLVNLAAAEGHPASVMDMSFA
EHHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEEEECCEEEEEEECCCCCCCEEEHHHH
NQALSAEFILNNHSKLEKDVYKVPDDIDQKVAKLKLDSMGIEIDILTPEQIAYMSSWEHG
HHHHEEEEEECCCHHHHHHHHCCCCHHHHHHHHEEHHHCCEEEEEECHHHHHHHCCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]