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The map label for this gene is lysA [H]

Identifier: 195952897

GI number: 195952897

Start: 459282

End: 460544

Strand: Direct

Name: lysA [H]

Synonym: HY04AAS1_0522

Alternate gene names: 195952897

Gene position: 459282-460544 (Clockwise)

Preceding gene: 195952896

Following gene: 195952898

Centisome position: 29.45

GC content: 35.55

Gene sequence:

>1263_bases
ATGCTAAAAGATTACAACAAGTATTTAGATTACAAAGAAGATAAGTTATTTTTAGAAAATGTGGATTTAGAAGAGCTGGC
TAAAGAATTTGGGACACCTCTTTATGTGTATTCGGCTTCTTACATAAAAGATAAAGCTAAAGCCTACAAAGAGGCGTTCA
AAGATACCGATTTTCACTACGCTTTGAAGGCAAATGGAAATTTAAGCATTATAAAGCTTTTAAAAGATGAGGGTTTTGGG
GCTGACATAGTTTCTGGTGGTGAGCTTAGAAAAGCTATAAAAGCCGGGATAGAGGCTTCTAAGATAGTTTATGCAGGTGT
TGGTAAAACTATGGAAGAGTTAAAAGCTGCCGTTGAAGCCGAGATTAAAATGTTCAACGTAGAATCGTCGATAGAACTCG
ATATATTAAACGATATAGCAAAAAATCTTGGGAAAAAAGCCAACGTAGCAATAAGAGTAAATCCTGACGTAGACCCTAAA
ACCCATCCTTATATATCCACTGGTATGAAAAAAAGCAAATTTGGAGTTGATATAAAAACTGCTTACAAAGAGTATCAGTA
TGCTAAAAGCCTAAAACACCTTAATGTAATAGGTATACACTGTCACATAGGTTCCCAGCTTTTGGATGTATCACCCTATA
TAGAAGCTTCTGAGAAAGTAAGAGAGCTTTACGACAAGCTTGTAAAAGATGGGTTTGATATTAAGTATATAGATATGGGA
GGAGGCTTAGGTATAAAGTATAAACCCGAAGAGCAGGAACCACATCCTAAAGATTTAAAAGAAGCTTTGTATCCGGCTTT
TAAAGATATAAAAGCAAGGCTTTGTTTAGAACCCGGCAGATCGATGGTAGGCAACGCTGGTATCTTGATAACAGAAGTGC
AATTTTTAAAAGATAAAGGTCATAAACATTTTGTAATAGTAGATGCTGGCATGAATGACCTTATAAGGCCCTCCATATAC
GGGGCTTATCACCATATAGTCCCTACTCACAACAAATATAAAGAAGATTTTATTAAAACTGATATAGTAGGACCAATATG
TGAAACTGGAGACTTTTTAGCTCAAGACAGAGAAATACATAAAGTAGACAGAGGAGATTATCTTGCAGTATTAAGCGCCG
GTGCTTACGGATTTTCTATGTCAAGCCATTATAATATAAGGCCAAGAGCGGCAGAAGTGCTTATAGAAAATGGGAAATAT
AGGCTTATAAGAAGCAGGGAAACTTACGATTATATAGATTACGATGAAGCTATTTTTTTATGA

Upstream 100 bases:

>100_bases
ACGATTTTCTAAAAGCTCAAAAATTAAAACCTTTTATATCCATATCTCATGAGAAGGAGTTTTCTGTAGCAGTTTGTTAT
ATCACAAAAGAGGAGAGAAT

Downstream 100 bases:

>100_bases
TGTTATAATAGTAGGGTGGGTGAAGATATGGAATTTAGAGATAATCTAAGGATACTAGCGGAAGCTATAGAAAGGGAGTC
CGTTCTAATACATAGATCAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLKDYNKYLDYKEDKLFLENVDLEELAKEFGTPLYVYSASYIKDKAKAYKEAFKDTDFHYALKANGNLSIIKLLKDEGFG
ADIVSGGELRKAIKAGIEASKIVYAGVGKTMEELKAAVEAEIKMFNVESSIELDILNDIAKNLGKKANVAIRVNPDVDPK
THPYISTGMKKSKFGVDIKTAYKEYQYAKSLKHLNVIGIHCHIGSQLLDVSPYIEASEKVRELYDKLVKDGFDIKYIDMG
GGLGIKYKPEEQEPHPKDLKEALYPAFKDIKARLCLEPGRSMVGNAGILITEVQFLKDKGHKHFVIVDAGMNDLIRPSIY
GAYHHIVPTHNKYKEDFIKTDIVGPICETGDFLAQDREIHKVDRGDYLAVLSAGAYGFSMSSHYNIRPRAAEVLIENGKY
RLIRSRETYDYIDYDEAIFL

Sequences:

>Translated_420_residues
MLKDYNKYLDYKEDKLFLENVDLEELAKEFGTPLYVYSASYIKDKAKAYKEAFKDTDFHYALKANGNLSIIKLLKDEGFG
ADIVSGGELRKAIKAGIEASKIVYAGVGKTMEELKAAVEAEIKMFNVESSIELDILNDIAKNLGKKANVAIRVNPDVDPK
THPYISTGMKKSKFGVDIKTAYKEYQYAKSLKHLNVIGIHCHIGSQLLDVSPYIEASEKVRELYDKLVKDGFDIKYIDMG
GGLGIKYKPEEQEPHPKDLKEALYPAFKDIKARLCLEPGRSMVGNAGILITEVQFLKDKGHKHFVIVDAGMNDLIRPSIY
GAYHHIVPTHNKYKEDFIKTDIVGPICETGDFLAQDREIHKVDRGDYLAVLSAGAYGFSMSSHYNIRPRAAEVLIENGKY
RLIRSRETYDYIDYDEAIFL
>Mature_420_residues
MLKDYNKYLDYKEDKLFLENVDLEELAKEFGTPLYVYSASYIKDKAKAYKEAFKDTDFHYALKANGNLSIIKLLKDEGFG
ADIVSGGELRKAIKAGIEASKIVYAGVGKTMEELKAAVEAEIKMFNVESSIELDILNDIAKNLGKKANVAIRVNPDVDPK
THPYISTGMKKSKFGVDIKTAYKEYQYAKSLKHLNVIGIHCHIGSQLLDVSPYIEASEKVRELYDKLVKDGFDIKYIDMG
GGLGIKYKPEEQEPHPKDLKEALYPAFKDIKARLCLEPGRSMVGNAGILITEVQFLKDKGHKHFVIVDAGMNDLIRPSIY
GAYHHIVPTHNKYKEDFIKTDIVGPICETGDFLAQDREIHKVDRGDYLAVLSAGAYGFSMSSHYNIRPRAAEVLIENGKY
RLIRSRETYDYIDYDEAIFL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=24.3386243386243, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI22538418, Length=354, Percent_Identity=24.2937853107345, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361583, Length=354, Percent_Identity=24.2937853107345, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI16506287, Length=350, Percent_Identity=23.4285714285714, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=424, Percent_Identity=34.6698113207547, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17562780, Length=403, Percent_Identity=27.2952853598015, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24586472, Length=387, Percent_Identity=23.5142118863049, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=382, Percent_Identity=23.2984293193717, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47440; Mature: 47440

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDYNKYLDYKEDKLFLENVDLEELAKEFGTPLYVYSASYIKDKAKAYKEAFKDTDFHY
CCCCCHHHCCCCCCEEEEECCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCEEE
ALKANGNLSIIKLLKDEGFGADIVSGGELRKAIKAGIEASKIVYAGVGKTMEELKAAVEA
EEECCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
EIKMFNVESSIELDILNDIAKNLGKKANVAIRVNPDVDPKTHPYISTGMKKSKFGVDIKT
HEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCHHCCCCHHH
AYKEYQYAKSLKHLNVIGIHCHIGSQLLDVSPYIEASEKVRELYDKLVKDGFDIKYIDMG
HHHHHHHHHHHCCCEEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLGIKYKPEEQEPHPKDLKEALYPAFKDIKARLCLEPGRSMVGNAGILITEVQFLKDKG
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHHCCC
HKHFVIVDAGMNDLIRPSIYGAYHHIVPTHNKYKEDFIKTDIVGPICETGDFLAQDREIH
CEEEEEEECCCCCCCCCHHHCCHHEECCCCCHHHHHHHHHHCCCCHHCCCHHHHCCCHHH
KVDRGDYLAVLSAGAYGFSMSSHYNIRPRAAEVLIENGKYRLIRSRETYDYIDYDEAIFL
HCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHEEECCCEEEEECCCCCCCCCCCCEEEC
>Mature Secondary Structure
MLKDYNKYLDYKEDKLFLENVDLEELAKEFGTPLYVYSASYIKDKAKAYKEAFKDTDFHY
CCCCCHHHCCCCCCEEEEECCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCEEE
ALKANGNLSIIKLLKDEGFGADIVSGGELRKAIKAGIEASKIVYAGVGKTMEELKAAVEA
EEECCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
EIKMFNVESSIELDILNDIAKNLGKKANVAIRVNPDVDPKTHPYISTGMKKSKFGVDIKT
HEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCHHCCCCHHH
AYKEYQYAKSLKHLNVIGIHCHIGSQLLDVSPYIEASEKVRELYDKLVKDGFDIKYIDMG
HHHHHHHHHHHCCCEEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLGIKYKPEEQEPHPKDLKEALYPAFKDIKARLCLEPGRSMVGNAGILITEVQFLKDKG
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHHCCC
HKHFVIVDAGMNDLIRPSIYGAYHHIVPTHNKYKEDFIKTDIVGPICETGDFLAQDREIH
CEEEEEEECCCCCCCCCHHHCCHHEECCCCCHHHHHHHHHHCCCCHHCCCHHHHCCCHHH
KVDRGDYLAVLSAGAYGFSMSSHYNIRPRAAEVLIENGKYRLIRSRETYDYIDYDEAIFL
HCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHEEECCCEEEEECCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]