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The map label for this gene is rnc

Identifier: 195952887

GI number: 195952887

Start: 449916

End: 450614

Strand: Direct

Name: rnc

Synonym: HY04AAS1_0512

Alternate gene names: 195952887

Gene position: 449916-450614 (Clockwise)

Preceding gene: 195952886

Following gene: 195952888

Centisome position: 28.85

GC content: 32.62

Gene sequence:

>699_bases
ATGGATAGTTTTGAGCTTTTAGAAGAAAAAATAGGTTATAGATTTAAGGATAAAAATTTAGTAAAGAAAGCTTTTACACA
TATATCTTTTTCCAAAAGCTCAGAAAACTACGAAGTATTAGAATTTTTAGGGGATGCTCTCGTTAATTTTATGACCGTAA
ATATATTGGTGGAGGCTTTTCCAAATAAAAAGGAAGGTGAGCTCTCTCAATTGAAATCTTTTTTAATAAGCGAAGAGTTT
TTAGCTAGTCTCGCCAAATCTCTAAACTTTGAAAAATATATACTTATAAGTAAGGGTGAAGAGCTAAAGGGTTCTAACAA
AAACCCTTCTATTCTCTGCGATGTGTTTGAAGCTTTTTGGGCTGCTATATACATAGACAGTGGATACGATTGTAAGCTTA
CAAAAAGTTTGTTTGAGCATCATTTTAAAAGCCAAATACTTGAGATGGTAAACTCAAATAGCTTAAAGCAGGACTACAAA
ACAGCTTTACAGGAGATAACTCAAAAAAAGTGGAAAGAAAGACCTATATACAACGTCATAAGCGTAGAAGGTCCAGAGCA
TAGGAAAACCTTTACAGTTGAATGTCTATTTAAAGATCTAAGAACCACAGGAAAAGGCAACAGTAAAAAGTACGCGGAAC
AAGAGGCAGCAAAAAATATGCTTCAGATAATTCAAGATAATGAAAAGAAAAAAACTTGA

Upstream 100 bases:

>100_bases
TATAAACTACGATGTGAAAAACATTTTGTCAAATTCTTTTGGTTTTGGAGGCACAAACGCCTGTATAATACTTAGCAAAG
TTGATTAAAAACACAATTAA

Downstream 100 bases:

>100_bases
AGAAATTTTAAAAAAAATACCACCAAAAGCTTGGGATAAAATAATATCAAAAGAACCAGAATATTCTTACTTTAAAAATC
TTACGCCTTTTTATCATTTT

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MDSFELLEEKIGYRFKDKNLVKKAFTHISFSKSSENYEVLEFLGDALVNFMTVNILVEAFPNKKEGELSQLKSFLISEEF
LASLAKSLNFEKYILISKGEELKGSNKNPSILCDVFEAFWAAIYIDSGYDCKLTKSLFEHHFKSQILEMVNSNSLKQDYK
TALQEITQKKWKERPIYNVISVEGPEHRKTFTVECLFKDLRTTGKGNSKKYAEQEAAKNMLQIIQDNEKKKT

Sequences:

>Translated_232_residues
MDSFELLEEKIGYRFKDKNLVKKAFTHISFSKSSENYEVLEFLGDALVNFMTVNILVEAFPNKKEGELSQLKSFLISEEF
LASLAKSLNFEKYILISKGEELKGSNKNPSILCDVFEAFWAAIYIDSGYDCKLTKSLFEHHFKSQILEMVNSNSLKQDYK
TALQEITQKKWKERPIYNVISVEGPEHRKTFTVECLFKDLRTTGKGNSKKYAEQEAAKNMLQIIQDNEKKKT
>Mature_232_residues
MDSFELLEEKIGYRFKDKNLVKKAFTHISFSKSSENYEVLEFLGDALVNFMTVNILVEAFPNKKEGELSQLKSFLISEEF
LASLAKSLNFEKYILISKGEELKGSNKNPSILCDVFEAFWAAIYIDSGYDCKLTKSLFEHHFKSQILEMVNSNSLKQDYK
TALQEITQKKWKERPIYNVISVEGPEHRKTFTVECLFKDLRTTGKGNSKKYAEQEAAKNMLQIIQDNEKKKT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=30.2631578947368, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=30.2631578947368, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI29294649, Length=264, Percent_Identity=25.3787878787879, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI29294651, Length=264, Percent_Identity=25.3787878787879, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=31.5533980582524, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17552834, Length=267, Percent_Identity=28.4644194756554, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=218, Percent_Identity=27.0642201834862, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=218, Percent_Identity=27.0642201834862, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137682, Length=243, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17738129, Length=185, Percent_Identity=25.9459459459459, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_HYDS0 (B4U7T8)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121177.1
- ProteinModelPortal:   B4U7T8
- SMR:   B4U7T8
- GeneID:   6743308
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0512
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK2748388
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26830; Mature: 26830

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFELLEEKIGYRFKDKNLVKKAFTHISFSKSSENYEVLEFLGDALVNFMTVNILVEAF
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PNKKEGELSQLKSFLISEEFLASLAKSLNFEKYILISKGEELKGSNKNPSILCDVFEAFW
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
AAIYIDSGYDCKLTKSLFEHHFKSQILEMVNSNSLKQDYKTALQEITQKKWKERPIYNVI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
SVEGPEHRKTFTVECLFKDLRTTGKGNSKKYAEQEAAKNMLQIIQDNEKKKT
ECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDSFELLEEKIGYRFKDKNLVKKAFTHISFSKSSENYEVLEFLGDALVNFMTVNILVEAF
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PNKKEGELSQLKSFLISEEFLASLAKSLNFEKYILISKGEELKGSNKNPSILCDVFEAFW
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
AAIYIDSGYDCKLTKSLFEHHFKSQILEMVNSNSLKQDYKTALQEITQKKWKERPIYNVI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
SVEGPEHRKTFTVECLFKDLRTTGKGNSKKYAEQEAAKNMLQIIQDNEKKKT
ECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA