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The map label for this gene is fabF [H]

Identifier: 195952886

GI number: 195952886

Start: 448662

End: 449903

Strand: Direct

Name: fabF [H]

Synonym: HY04AAS1_0511

Alternate gene names: 195952886

Gene position: 448662-449903 (Clockwise)

Preceding gene: 195952885

Following gene: 195952887

Centisome position: 28.77

GC content: 40.02

Gene sequence:

>1242_bases
ATGAGAAGAGTGGTTATAACAGGTATAGGTGTTGTATCACCTATAGGAAACAACGTAAATGATTTTTGGCAAAACCTTGT
GGCTGGGAAAAGCGGCATAGATACCATCTCTTCTTTTGATCCAGACAAATATGGTTTGACAGTTAAAATAGCTGCCGAAG
TGAAAAACTTCAACCCAGAAGATTATTTTGATAAAAAAGATGCCCAAAAACTTTCCGATTTTATAAAGTTTGCTTACGCA
GCCGCAATGGAAGCTATGAAAGATGCCAGTCTTGAAAATGCCAATATAGATAAAGATAGAGTTGGTGTGATAGTAGGTAC
AGGTATAGGTGGATTAAAAGATATAGAAGAACAAAATGAGACTTTAAACGAAAAGGGTGCAAGAAGGGTTTCTCCCTTCT
TCATACCTTACGGCATAGCAAATATGGCATCTGGGGTCATAGCCATAAAATATGGATTTAGAGGACCAAACTATTGCGTA
GTATCTGCTTGCGCCACTGGTAATCATTCTATAGGAGATGCTTTCAGGATTATACAAAGAGGTGATGCCGATATCATGAT
AGCTGGCGGTACAGAAAGTGCCATAACCCCACTCGGTATAGCTGGTTTTGCTTCGCTAAAAGCCCTGTCCACTAGAAACG
ATGAACCTCAAAAAGCCTCAAGGCCTTTTGATAGTCAAAGAGATGGCTTTGTAATGGGAGAAGGAGCTGGGATATTGATA
TTAGAGGAGTACGAACACGCTAAGAAAAGAGGAGCAAAGATATATGCTGAGATAAAAGGGTACGCAGCGACAGACGATGC
TTTCCACGTGACGGCTCCATGCACAGATGGAGAAGGCGCCGCTATGTGTATGAGATTGGCTTTAGAAGATGCCTCTTTAA
ACCCAGAAGATATAGATTATATAAACGCTCACGGCACTTCAACACCTCTAAACGATAAGATAGAAACCTTGGCGATAAAG
AAGATTTTTAAAGATCACGCTTATAAGCTAAAGATGAGTTCCAATAAATCCATGATTGGGCATCTATTGGGAGCTGCATC
AGCGGTAGAGGCGGTAGCATCTGTTAAAACTATTGAAACTGGCATAATACCACCCACTATAAACCTCGAAAATCCGGATC
CTGAATGCGATTTGGATTATGTGCCAAACAAAGCTATAAACTACGATGTGAAAAACATTTTGTCAAATTCTTTTGGTTTT
GGAGGCACAAACGCCTGTATAATACTTAGCAAAGTTGATTAA

Upstream 100 bases:

>100_bases
TGAGCTTTGAAGAAGAGTTTAACATAGAAATACCAGACGAAGACGCTGAAAAGATAAAGACTGTCGGTGATGTTATAAAC
TATCTAAATGAAAAGTTAAA

Downstream 100 bases:

>100_bases
AAACACAATTAAATGGATAGTTTTGAGCTTTTAGAAGAAAAAATAGGTTATAGATTTAAGGATAAAAATTTAGTAAAGAA
AGCTTTTACACATATATCTT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MRRVVITGIGVVSPIGNNVNDFWQNLVAGKSGIDTISSFDPDKYGLTVKIAAEVKNFNPEDYFDKKDAQKLSDFIKFAYA
AAMEAMKDASLENANIDKDRVGVIVGTGIGGLKDIEEQNETLNEKGARRVSPFFIPYGIANMASGVIAIKYGFRGPNYCV
VSACATGNHSIGDAFRIIQRGDADIMIAGGTESAITPLGIAGFASLKALSTRNDEPQKASRPFDSQRDGFVMGEGAGILI
LEEYEHAKKRGAKIYAEIKGYAATDDAFHVTAPCTDGEGAAMCMRLALEDASLNPEDIDYINAHGTSTPLNDKIETLAIK
KIFKDHAYKLKMSSNKSMIGHLLGAASAVEAVASVKTIETGIIPPTINLENPDPECDLDYVPNKAINYDVKNILSNSFGF
GGTNACIILSKVD

Sequences:

>Translated_413_residues
MRRVVITGIGVVSPIGNNVNDFWQNLVAGKSGIDTISSFDPDKYGLTVKIAAEVKNFNPEDYFDKKDAQKLSDFIKFAYA
AAMEAMKDASLENANIDKDRVGVIVGTGIGGLKDIEEQNETLNEKGARRVSPFFIPYGIANMASGVIAIKYGFRGPNYCV
VSACATGNHSIGDAFRIIQRGDADIMIAGGTESAITPLGIAGFASLKALSTRNDEPQKASRPFDSQRDGFVMGEGAGILI
LEEYEHAKKRGAKIYAEIKGYAATDDAFHVTAPCTDGEGAAMCMRLALEDASLNPEDIDYINAHGTSTPLNDKIETLAIK
KIFKDHAYKLKMSSNKSMIGHLLGAASAVEAVASVKTIETGIIPPTINLENPDPECDLDYVPNKAINYDVKNILSNSFGF
GGTNACIILSKVD
>Mature_413_residues
MRRVVITGIGVVSPIGNNVNDFWQNLVAGKSGIDTISSFDPDKYGLTVKIAAEVKNFNPEDYFDKKDAQKLSDFIKFAYA
AAMEAMKDASLENANIDKDRVGVIVGTGIGGLKDIEEQNETLNEKGARRVSPFFIPYGIANMASGVIAIKYGFRGPNYCV
VSACATGNHSIGDAFRIIQRGDADIMIAGGTESAITPLGIAGFASLKALSTRNDEPQKASRPFDSQRDGFVMGEGAGILI
LEEYEHAKKRGAKIYAEIKGYAATDDAFHVTAPCTDGEGAAMCMRLALEDASLNPEDIDYINAHGTSTPLNDKIETLAIK
KIFKDHAYKLKMSSNKSMIGHLLGAASAVEAVASVKTIETGIIPPTINLENPDPECDLDYVPNKAINYDVKNILSNSFGF
GGTNACIILSKVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=47.9713603818616, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI223972627, Length=153, Percent_Identity=52.9411764705882, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=27.5058275058275, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=51.9417475728155, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=39.5180722891566, Blast_Score=271, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=38.8489208633094, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=41.6666666666667, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=428, Percent_Identity=25, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=416, Percent_Identity=26.4423076923077, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=39.1891891891892, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=44.6300715990453, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=26.5258215962441, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19920632, Length=426, Percent_Identity=26.5258215962441, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=25.4672897196262, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44283; Mature: 44283

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGIGVVSPIGNNVNDFWQNLVAGKSGIDTISSFDPDKYGLTVKIAAEVKNFNPE
CCEEEEECCCEECCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCH
DYFDKKDAQKLSDFIKFAYAAAMEAMKDASLENANIDKDRVGVIVGTGIGGLKDIEEQNE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
TLNEKGARRVSPFFIPYGIANMASGVIAIKYGFRGPNYCVVSACATGNHSIGDAFRIIQR
HHHHCCCCCCCCEEECCCHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHC
GDADIMIAGGTESAITPLGIAGFASLKALSTRNDEPQKASRPFDSQRDGFVMGEGAGILI
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKKRGAKIYAEIKGYAATDDAFHVTAPCTDGEGAAMCMRLALEDASLNPEDIDY
ECCHHHHHHCCCEEEEEEECEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCE
INAHGTSTPLNDKIETLAIKKIFKDHAYKLKMSSNKSMIGHLLGAASAVEAVASVKTIET
EECCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIIPPTINLENPDPECDLDYVPNKAINYDVKNILSNSFGFGGTNACIILSKVD
CCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRRVVITGIGVVSPIGNNVNDFWQNLVAGKSGIDTISSFDPDKYGLTVKIAAEVKNFNPE
CCEEEEECCCEECCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEEEEECCCCCH
DYFDKKDAQKLSDFIKFAYAAAMEAMKDASLENANIDKDRVGVIVGTGIGGLKDIEEQNE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
TLNEKGARRVSPFFIPYGIANMASGVIAIKYGFRGPNYCVVSACATGNHSIGDAFRIIQR
HHHHCCCCCCCCEEECCCHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHC
GDADIMIAGGTESAITPLGIAGFASLKALSTRNDEPQKASRPFDSQRDGFVMGEGAGILI
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKKRGAKIYAEIKGYAATDDAFHVTAPCTDGEGAAMCMRLALEDASLNPEDIDY
ECCHHHHHHCCCEEEEEEECEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCE
INAHGTSTPLNDKIETLAIKKIFKDHAYKLKMSSNKSMIGHLLGAASAVEAVASVKTIET
EECCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIIPPTINLENPDPECDLDYVPNKAINYDVKNILSNSFGFGGTNACIILSKVD
CCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]