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The map label for this gene is bioA [H]

Identifier: 195952870

GI number: 195952870

Start: 436132

End: 437466

Strand: Direct

Name: bioA [H]

Synonym: HY04AAS1_0495

Alternate gene names: 195952870

Gene position: 436132-437466 (Clockwise)

Preceding gene: 195952869

Following gene: 195952871

Centisome position: 27.97

GC content: 36.25

Gene sequence:

>1335_bases
ATGAAGATTGAATCTTTGATGTTTTTAGAATCAACAGACAGAACATATTTTTGGCATCCATTTACCCAAATGAAGGTTTA
TGAAGAAGAAGGGGGCATTATATTTGAAAAAGGGGAAGGAGTTTATCTATACGATATTTATGGAAACAAATATATAGATG
CTATATCCTCTTTGTGGTGCAATATCCACGGACACAATCACCCAAAACTAAACCAAGCCCTTATAAACCAGCTCAACAAA
GTGGCTCATACCACAACACTTGGAAACTCCAACGTACCGGCTATTATGTTGGCTAAAAAACTTGTGGACATAACACCTTC
TTGCCTTGAAAGGGTTTTTTACTCTGAAGACGGCGCTGAGGCTATGGAAATAGCTATTAAGCTTAGTTATCATTACTTTA
AAAACTTAGACCAAGAAAGACCTTATTTTATAAGTTTTGAAGGGGCTTATCACGGTGATACCATAGGAAGTGTAAGTGTT
GGTAGTGTTTCTTTGTTTCACGATACTTATAAGCCTTTACTTTTTAAAACCTACAAACTCCCATCTCCATATCATTTTAC
AAAAACTAGTAGCACTGAAGAGCTTCTTGATATGCTTGAAAAGCTTTTAAAGGATATACATGATAAAACCTCAGCTATAG
TTATGGAATCTGGTATGCAAGCAGCTTCTGGATTCTTAGTGTATCCTAAGGGTTTTATGAAAAGCGTTTATGAAATGGCT
AAGCATTACGGTGTTCTTTTTATAGCCGATGAAGTGGCCACTGGTTTTGGTAGGACCGGTAGCATGTTTTATGTAGAACA
AGAGGATATATGTCCAGATTTTATGGCTCTTGGTAAAGGTATAACCGGTGGTTATATGCCTTTGGCAGCCACACTTACCA
CAAAAGAAATATACGATGCTTTTTTAGGTGAGTATGAAGAACTAAAACACTTTTTCCATGGCCATACATACACTGGCAAC
AATCTAGCATGCGCAGTGGCTCTTAAGAATATAGAGATCTTTGAAGAAGAAAACGTATTGGGGCTTTTAAAAGAAAAAAT
AGAATATCTTGAAAAACGTCTAAAAGAGTTTGAATCTTTAAAACACGTTAAAGAGACAAGACAGCTTGGATTTATGGCTG
CCATTGAACTAGCCAAAGACAAGAAAAAGCCCTATGAACTAAAAGAACGAATAGGTTTTAAAGTGGCAAATTACGCTAAG
AAAAAAGGTGTATTTTTAAGACCTCTTGGAAACAACATGATACTTGTGATGCCCCTTTCTATAGGCTTTGAAGAGATGGA
TAAGGTTTTAGATGTTTTGCATGAGTCCATAAAAGTTGTAACGGAGAGCCTATGA

Upstream 100 bases:

>100_bases
GAAAAAGATATATCTTTAAAGCAAGCTGCAATAGAGCTTGGCATACTTACAGAAGAGGAGTTTGATAAATACGTAAGACC
GGAGAAGATGGCAAAACCCC

Downstream 100 bases:

>100_bases
AATATTTTCTTTTAAAAACAGAACCAAGCTCTTATTCTTACGATATGCTTGAAAAAGAAGGTAAAACCGTTTGGGACGGG
GTTAAAAATCCCTTAGCTCA

Product: class III aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKIESLMFLESTDRTYFWHPFTQMKVYEEEGGIIFEKGEGVYLYDIYGNKYIDAISSLWCNIHGHNHPKLNQALINQLNK
VAHTTTLGNSNVPAIMLAKKLVDITPSCLERVFYSEDGAEAMEIAIKLSYHYFKNLDQERPYFISFEGAYHGDTIGSVSV
GSVSLFHDTYKPLLFKTYKLPSPYHFTKTSSTEELLDMLEKLLKDIHDKTSAIVMESGMQAASGFLVYPKGFMKSVYEMA
KHYGVLFIADEVATGFGRTGSMFYVEQEDICPDFMALGKGITGGYMPLAATLTTKEIYDAFLGEYEELKHFFHGHTYTGN
NLACAVALKNIEIFEEENVLGLLKEKIEYLEKRLKEFESLKHVKETRQLGFMAAIELAKDKKKPYELKERIGFKVANYAK
KKGVFLRPLGNNMILVMPLSIGFEEMDKVLDVLHESIKVVTESL

Sequences:

>Translated_444_residues
MKIESLMFLESTDRTYFWHPFTQMKVYEEEGGIIFEKGEGVYLYDIYGNKYIDAISSLWCNIHGHNHPKLNQALINQLNK
VAHTTTLGNSNVPAIMLAKKLVDITPSCLERVFYSEDGAEAMEIAIKLSYHYFKNLDQERPYFISFEGAYHGDTIGSVSV
GSVSLFHDTYKPLLFKTYKLPSPYHFTKTSSTEELLDMLEKLLKDIHDKTSAIVMESGMQAASGFLVYPKGFMKSVYEMA
KHYGVLFIADEVATGFGRTGSMFYVEQEDICPDFMALGKGITGGYMPLAATLTTKEIYDAFLGEYEELKHFFHGHTYTGN
NLACAVALKNIEIFEEENVLGLLKEKIEYLEKRLKEFESLKHVKETRQLGFMAAIELAKDKKKPYELKERIGFKVANYAK
KKGVFLRPLGNNMILVMPLSIGFEEMDKVLDVLHESIKVVTESL
>Mature_444_residues
MKIESLMFLESTDRTYFWHPFTQMKVYEEEGGIIFEKGEGVYLYDIYGNKYIDAISSLWCNIHGHNHPKLNQALINQLNK
VAHTTTLGNSNVPAIMLAKKLVDITPSCLERVFYSEDGAEAMEIAIKLSYHYFKNLDQERPYFISFEGAYHGDTIGSVSV
GSVSLFHDTYKPLLFKTYKLPSPYHFTKTSSTEELLDMLEKLLKDIHDKTSAIVMESGMQAASGFLVYPKGFMKSVYEMA
KHYGVLFIADEVATGFGRTGSMFYVEQEDICPDFMALGKGITGGYMPLAATLTTKEIYDAFLGEYEELKHFFHGHTYTGN
NLACAVALKNIEIFEEENVLGLLKEKIEYLEKRLKEFESLKHVKETRQLGFMAAIELAKDKKKPYELKERIGFKVANYAK
KKGVFLRPLGNNMILVMPLSIGFEEMDKVLDVLHESIKVVTESL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=374, Percent_Identity=31.5508021390374, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI37574042, Length=456, Percent_Identity=29.3859649122807, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4557809, Length=411, Percent_Identity=27.7372262773723, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI226442705, Length=455, Percent_Identity=28.7912087912088, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442709, Length=410, Percent_Identity=30, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=27.5229357798165, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI24119277, Length=389, Percent_Identity=24.6786632390745, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786991, Length=443, Percent_Identity=31.6027088036117, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI145693181, Length=422, Percent_Identity=28.9099526066351, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=30.1745635910224, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787560, Length=414, Percent_Identity=29.7101449275362, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=28.3333333333333, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789759, Length=358, Percent_Identity=30.1675977653631, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=341, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=29.8440979955457, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=27.7647058823529, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71992977, Length=386, Percent_Identity=26.9430051813472, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=328, Percent_Identity=27.7439024390244, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=387, Percent_Identity=24.031007751938, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=479, Percent_Identity=29.4363256784969, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=25, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=430, Percent_Identity=24.4186046511628, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161085790, Length=437, Percent_Identity=29.5194508009153, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574759, Length=443, Percent_Identity=29.5711060948081, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=27.0334928229665, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=26.463700234192, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50529; Mature: 50529

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIESLMFLESTDRTYFWHPFTQMKVYEEEGGIIFEKGEGVYLYDIYGNKYIDAISSLWC
CCCCCEEEEECCCCEEEECCCHHEEEEECCCCEEEECCCCEEEEEECCCHHHHHHHHHEE
NIHGHNHPKLNQALINQLNKVAHTTTLGNSNVPAIMLAKKLVDITPSCLERVFYSEDGAE
ECCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
AMEIAIKLSYHYFKNLDQERPYFISFEGAYHGDTIGSVSVGSVSLFHDTYKPLLFKTYKL
EEEEEEEEEHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCEEEEHHHHHHHHHEEEECC
PSPYHFTKTSSTEELLDMLEKLLKDIHDKTSAIVMESGMQAASGFLVYPKGFMKSVYEMA
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECHHHHHHHHHHH
KHYGVLFIADEVATGFGRTGSMFYVEQEDICPDFMALGKGITGGYMPLAATLTTKEIYDA
HHCCEEEEEHHHHHCCCCCCCEEEEECHHCCHHHHHHCCCCCCCCCHHEEHHHHHHHHHH
FLGEYEELKHFFHGHTYTGNNLACAVALKNIEIFEEENVLGLLKEKIEYLEKRLKEFESL
HHCCHHHHHHHHCCCCCCCCCEEEEEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
KHVKETRQLGFMAAIELAKDKKKPYELKERIGFKVANYAKKKGVFLRPLGNNMILVMPLS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCEEEEECCCCEEEEEECC
IGFEEMDKVLDVLHESIKVVTESL
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIESLMFLESTDRTYFWHPFTQMKVYEEEGGIIFEKGEGVYLYDIYGNKYIDAISSLWC
CCCCCEEEEECCCCEEEECCCHHEEEEECCCCEEEECCCCEEEEEECCCHHHHHHHHHEE
NIHGHNHPKLNQALINQLNKVAHTTTLGNSNVPAIMLAKKLVDITPSCLERVFYSEDGAE
ECCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
AMEIAIKLSYHYFKNLDQERPYFISFEGAYHGDTIGSVSVGSVSLFHDTYKPLLFKTYKL
EEEEEEEEEHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCEEEEHHHHHHHHHEEEECC
PSPYHFTKTSSTEELLDMLEKLLKDIHDKTSAIVMESGMQAASGFLVYPKGFMKSVYEMA
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEECHHHHHHHHHHH
KHYGVLFIADEVATGFGRTGSMFYVEQEDICPDFMALGKGITGGYMPLAATLTTKEIYDA
HHCCEEEEEHHHHHCCCCCCCEEEEECHHCCHHHHHHCCCCCCCCCHHEEHHHHHHHHHH
FLGEYEELKHFFHGHTYTGNNLACAVALKNIEIFEEENVLGLLKEKIEYLEKRLKEFESL
HHCCHHHHHHHHCCCCCCCCCEEEEEEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
KHVKETRQLGFMAAIELAKDKKKPYELKERIGFKVANYAKKKGVFLRPLGNNMILVMPLS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCEEEEECCCCEEEEEECC
IGFEEMDKVLDVLHESIKVVTESL
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]