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The map label for this gene is fumC [H]

Identifier: 195952869

GI number: 195952869

Start: 434748

End: 436142

Strand: Direct

Name: fumC [H]

Synonym: HY04AAS1_0494

Alternate gene names: 195952869

Gene position: 434748-436142 (Clockwise)

Preceding gene: 195952866

Following gene: 195952870

Centisome position: 27.88

GC content: 38.57

Gene sequence:

>1395_bases
ATGGAGTATAGGATTGAAAGAGATACCATGGGCGAAGTAAAAGTCCCAGCCGATAAGTACTGGGGAGCTCAAACTCAAAG
ATCTTTAATGTATTTTAACATTTCAAACGATATAATGCCTATTGAAACAATAAAGGCTTTGGCTCTCATCAAAAAAGCAG
CAGCTATTGTAAACAACGAACTTGGAAAACTAGATGATTATAGAAAAGATCTCATTGTAAGAGTAGTAGATGAGATATTA
GAAGGCAAACTAGATGAACATTTTCCTTTAAAAGTATGGCAAACTGGTTCTGGAACCCAAAGCAATATGAATGTAAATGA
GGTAATAGCAAATAGAGCGGCTGAGCTAGCGGGTAAACCCTTAGGCTCTAAAGACCCAATACATCCAAACGATCATGTTA
ACATGTCTCAGTCTTCCAACGATACATTCCCAACTGCTATGCATATATCTGCAGTACAAATCCTTCAAGATAAGCTCATA
CCATCTATAGAGTATCTAAGAGATGCTTTAAAGGAAAAAGCCGAAGAATTTAAGGATATTGTAAAAATAGGAAGGACTCA
TCTTCAAGATGCTGTACCAATGACCCTTGGACAAGAATTTGGTGGGTATGTGCATCAGTTAGACACTGCCCTTGAGCGTA
TAAAGTTGGTGTTACCGGAGTTAAAAGAAATAGGTATAGGTGCAACAGCAGTAGGCACAGGTCTAAACGCTACAAAAGGT
TTTGATAAAAGGATGGTAGAGGTTTTATCAGAGCTTACCGGTATAGATTTTAAATTGTCTAGAAACAAGTTTGCGTTTTT
AAGTTCTCACGATCCTTTTGTGATGGCAAGCGGTGCTATGAAATCTTTAGCGGCGGCTTTGATGAAGATAGCCAACGATA
TAAGATGGCTTGGCTCTGGTCCAAGAGCTGGCATAGGAGAACTCATACTCCCAGCCAATGAACCTGGTTCTTCAATAATG
CCAGGGAAGGTTAATCCCACACAATCAGAAGCTATGACGATGGTTTGTGTGCAGGTGATGGGAAACGATACGGTTATAGG
CTTTGCCGACTCCCAAGGTAATTTTGAACTAAACGTGTTTAATCCAGTGATTATATTTAACTTTTTAAACTCTGCAAAAC
TTCTATCTGATGCTATGAGATCATTTGCCGATCACATGGTAAAGGGTATAAAACCAAACCTAAAGAAAATAAACTCTTAT
GTGCAAGAGTCTCTTATGCTTGTGACAGCACTTAATCCTTACATTGGTTATGATAACGCTGCAAAAATAGCCAAAACTGC
CTATGAAAAAGATATATCTTTAAAGCAAGCTGCAATAGAGCTTGGCATACTTACAGAAGAGGAGTTTGATAAATACGTAA
GACCGGAGAAGATGGCAAAACCCCATGAAGATTGA

Upstream 100 bases:

>100_bases
CTATATCGTTTATGCAACATGATATGTATCAATTTATATGAAAGATACTTTGTATATGGCTTTTGATATATAATATTAAA
AAGCTTTATAGGAGTGTAGT

Downstream 100 bases:

>100_bases
ATCTTTGATGTTTTTAGAATCAACAGACAGAACATATTTTTGGCATCCATTTACCCAAATGAAGGTTTATGAAGAAGAAG
GGGGCATTATATTTGAAAAA

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MEYRIERDTMGEVKVPADKYWGAQTQRSLMYFNISNDIMPIETIKALALIKKAAAIVNNELGKLDDYRKDLIVRVVDEIL
EGKLDEHFPLKVWQTGSGTQSNMNVNEVIANRAAELAGKPLGSKDPIHPNDHVNMSQSSNDTFPTAMHISAVQILQDKLI
PSIEYLRDALKEKAEEFKDIVKIGRTHLQDAVPMTLGQEFGGYVHQLDTALERIKLVLPELKEIGIGATAVGTGLNATKG
FDKRMVEVLSELTGIDFKLSRNKFAFLSSHDPFVMASGAMKSLAAALMKIANDIRWLGSGPRAGIGELILPANEPGSSIM
PGKVNPTQSEAMTMVCVQVMGNDTVIGFADSQGNFELNVFNPVIIFNFLNSAKLLSDAMRSFADHMVKGIKPNLKKINSY
VQESLMLVTALNPYIGYDNAAKIAKTAYEKDISLKQAAIELGILTEEEFDKYVRPEKMAKPHED

Sequences:

>Translated_464_residues
MEYRIERDTMGEVKVPADKYWGAQTQRSLMYFNISNDIMPIETIKALALIKKAAAIVNNELGKLDDYRKDLIVRVVDEIL
EGKLDEHFPLKVWQTGSGTQSNMNVNEVIANRAAELAGKPLGSKDPIHPNDHVNMSQSSNDTFPTAMHISAVQILQDKLI
PSIEYLRDALKEKAEEFKDIVKIGRTHLQDAVPMTLGQEFGGYVHQLDTALERIKLVLPELKEIGIGATAVGTGLNATKG
FDKRMVEVLSELTGIDFKLSRNKFAFLSSHDPFVMASGAMKSLAAALMKIANDIRWLGSGPRAGIGELILPANEPGSSIM
PGKVNPTQSEAMTMVCVQVMGNDTVIGFADSQGNFELNVFNPVIIFNFLNSAKLLSDAMRSFADHMVKGIKPNLKKINSY
VQESLMLVTALNPYIGYDNAAKIAKTAYEKDISLKQAAIELGILTEEEFDKYVRPEKMAKPHED
>Mature_464_residues
MEYRIERDTMGEVKVPADKYWGAQTQRSLMYFNISNDIMPIETIKALALIKKAAAIVNNELGKLDDYRKDLIVRVVDEIL
EGKLDEHFPLKVWQTGSGTQSNMNVNEVIANRAAELAGKPLGSKDPIHPNDHVNMSQSSNDTFPTAMHISAVQILQDKLI
PSIEYLRDALKEKAEEFKDIVKIGRTHLQDAVPMTLGQEFGGYVHQLDTALERIKLVLPELKEIGIGATAVGTGLNATKG
FDKRMVEVLSELTGIDFKLSRNKFAFLSSHDPFVMASGAMKSLAAALMKIANDIRWLGSGPRAGIGELILPANEPGSSIM
PGKVNPTQSEAMTMVCVQVMGNDTVIGFADSQGNFELNVFNPVIIFNFLNSAKLLSDAMRSFADHMVKGIKPNLKKINSY
VQESLMLVTALNPYIGYDNAAKIAKTAYEKDISLKQAAIELGILTEEEFDKYVRPEKMAKPHED

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=59.4360086767896, Blast_Score=552, Evalue=1e-157,
Organism=Escherichia coli, GI1787896, Length=455, Percent_Identity=57.3626373626374, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=41.4316702819957, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=60.4347826086956, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=59.0214067278288, Blast_Score=405, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.1344902386117, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=58.0993520518359, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=58.0993520518359, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=55.5075593952484, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=55.4838709677419, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=49.3506493506493, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51244; Mature: 51244

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTMGEVKVPADKYWGAQTQRSLMYFNISNDIMPIETIKALALIKKAAAIVNNE
CCEEECCCCCCCEECCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LGKLDDYRKDLIVRVVDEILEGKLDEHFPLKVWQTGSGTQSNMNVNEVIANRAAELAGKP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
LGSKDPIHPNDHVNMSQSSNDTFPTAMHISAVQILQDKLIPSIEYLRDALKEKAEEFKDI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDAVPMTLGQEFGGYVHQLDTALERIKLVLPELKEIGIGATAVGTGLNATKG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
FDKRMVEVLSELTGIDFKLSRNKFAFLSSHDPFVMASGAMKSLAAALMKIANDIRWLGSG
HHHHHHHHHHHHCCCCEEECCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
PRAGIGELILPANEPGSSIMPGKVNPTQSEAMTMVCVQVMGNDTVIGFADSQGNFELNVF
CCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
NPVIIFNFLNSAKLLSDAMRSFADHMVKGIKPNLKKINSYVQESLMLVTALNPYIGYDNA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
AKIAKTAYEKDISLKQAAIELGILTEEEFDKYVRPEKMAKPHED
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MEYRIERDTMGEVKVPADKYWGAQTQRSLMYFNISNDIMPIETIKALALIKKAAAIVNNE
CCEEECCCCCCCEECCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LGKLDDYRKDLIVRVVDEILEGKLDEHFPLKVWQTGSGTQSNMNVNEVIANRAAELAGKP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
LGSKDPIHPNDHVNMSQSSNDTFPTAMHISAVQILQDKLIPSIEYLRDALKEKAEEFKDI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDAVPMTLGQEFGGYVHQLDTALERIKLVLPELKEIGIGATAVGTGLNATKG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
FDKRMVEVLSELTGIDFKLSRNKFAFLSSHDPFVMASGAMKSLAAALMKIANDIRWLGSG
HHHHHHHHHHHHCCCCEEECCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
PRAGIGELILPANEPGSSIMPGKVNPTQSEAMTMVCVQVMGNDTVIGFADSQGNFELNVF
CCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEE
NPVIIFNFLNSAKLLSDAMRSFADHMVKGIKPNLKKINSYVQESLMLVTALNPYIGYDNA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
AKIAKTAYEKDISLKQAAIELGILTEEEFDKYVRPEKMAKPHED
HHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]