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The map label for this gene is tlyA [H]

Identifier: 195952821

GI number: 195952821

Start: 386724

End: 387464

Strand: Direct

Name: tlyA [H]

Synonym: HY04AAS1_0443

Alternate gene names: 195952821

Gene position: 386724-387464 (Clockwise)

Preceding gene: 195952820

Following gene: 195952822

Centisome position: 24.8

GC content: 33.06

Gene sequence:

>741_bases
GTGAAAAAAAGACTAGATCTATTGTTGGTGGAAAAGGGCTTGGTTTCTTCTCGTGAGAAAGCTCAAGCTTTTATAATGGA
GGGAAGGGTTTTTGTAAATGGTAAAGCTGTTTTAAAAGCTGGCACCCTTGTGCAAGAAGAAGATGGTATTGAGCTTTTAG
GAGAAGAAAAATTTGTATCAAGAGCAGGTTATAAGCTTGAAAACGCCATAAAAGAGTTTGATGTGGATGTGTCTGAGAAA
ATATGCCTTGATATAGGATCTTCTACGGGTGGGTTTACGGATTGTCTTCTTCAATACGGTGCAAAATTGGTTTATGCTGT
AGACGTAGGGCATCTTCAAATGCATGAAAAGCTAAGAAAAGATCCAAGGGTAATGTTGTTTGAAGATACAGACATAAGAG
TTTTTAAAAAGCCAGATGATATCGATTTTGATATTGTTACTGTAGATGTGTCTTTTATCTCTCTTAAGAAGATAGGAGAG
TATATTAAAAATCTTTGCTCTTATTATACAAAACTTCTTATGCTTGTAAAACCTCAATTTGAGCTTTCTCCAAAATATCT
AAAAAAAGGAATAGTAAAAGATGATAGTGCTAAAATGCTTGCTTTAGAAAGTGTCATATCTCATTTTGAATCTATAGGTT
TTGAGCTTTTAGCATATACAAAAGCAAGACCAAAAGGTACCAAAGGAAACGAAGAATTTTTTACTTATTTCATATTAAAG
GATTATAATAAGACAAAATGA

Upstream 100 bases:

>100_bases
TAGGTATATTTACCATCGTAGATAGAGAAGAAGGCGCCAAAGAAAATATAGAAAAGGAAGGTTTTAAATTTTATTCTGTG
TTTAAATTATTTGAGCTTTT

Downstream 100 bases:

>100_bases
AAAACATACTTTCTTTTTTAGGTTTTTTTATAGTTGTTGTATTTGTGCTTTTAGGAGTATATGTTTATAGCGTAAGTATT
GGGCTTCCGGACGTGAGAGC

Product: hemolysin A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKKRLDLLLVEKGLVSSREKAQAFIMEGRVFVNGKAVLKAGTLVQEEDGIELLGEEKFVSRAGYKLENAIKEFDVDVSEK
ICLDIGSSTGGFTDCLLQYGAKLVYAVDVGHLQMHEKLRKDPRVMLFEDTDIRVFKKPDDIDFDIVTVDVSFISLKKIGE
YIKNLCSYYTKLLMLVKPQFELSPKYLKKGIVKDDSAKMLALESVISHFESIGFELLAYTKARPKGTKGNEEFFTYFILK
DYNKTK

Sequences:

>Translated_246_residues
MKKRLDLLLVEKGLVSSREKAQAFIMEGRVFVNGKAVLKAGTLVQEEDGIELLGEEKFVSRAGYKLENAIKEFDVDVSEK
ICLDIGSSTGGFTDCLLQYGAKLVYAVDVGHLQMHEKLRKDPRVMLFEDTDIRVFKKPDDIDFDIVTVDVSFISLKKIGE
YIKNLCSYYTKLLMLVKPQFELSPKYLKKGIVKDDSAKMLALESVISHFESIGFELLAYTKARPKGTKGNEEFFTYFILK
DYNKTK
>Mature_246_residues
MKKRLDLLLVEKGLVSSREKAQAFIMEGRVFVNGKAVLKAGTLVQEEDGIELLGEEKFVSRAGYKLENAIKEFDVDVSEK
ICLDIGSSTGGFTDCLLQYGAKLVYAVDVGHLQMHEKLRKDPRVMLFEDTDIRVFKKPDDIDFDIVTVDVSFISLKKIGE
YIKNLCSYYTKLLMLVKPQFELSPKYLKKGIVKDDSAKMLALESVISHFESIGFELLAYTKARPKGTKGNEEFFTYFILK
DYNKTK

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1189

COG function: function code J; Predicted rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004538
- InterPro:   IPR002877
- InterPro:   IPR002942 [H]

Pfam domain/function: PF01728 FtsJ; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 27954; Mature: 27954

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLDLLLVEKGLVSSREKAQAFIMEGRVFVNGKAVLKAGTLVQEEDGIELLGEEKFVS
CCCCCEEEEECCCHHCCHHHHHHHHEECEEEECCCEEEEECCEEECCCCCEECCCHHHHH
RAGYKLENAIKEFDVDVSEKICLDIGSSTGGFTDCLLQYGAKLVYAVDVGHLQMHEKLRK
HCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCC
DPRVMLFEDTDIRVFKKPDDIDFDIVTVDVSFISLKKIGEYIKNLCSYYTKLLMLVKPQF
CCCEEEEECCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ELSPKYLKKGIVKDDSAKMLALESVISHFESIGFELLAYTKARPKGTKGNEEFFTYFILK
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCEEEEEEEE
DYNKTK
CCCCCC
>Mature Secondary Structure
MKKRLDLLLVEKGLVSSREKAQAFIMEGRVFVNGKAVLKAGTLVQEEDGIELLGEEKFVS
CCCCCEEEEECCCHHCCHHHHHHHHEECEEEECCCEEEEECCEEECCCCCEECCCHHHHH
RAGYKLENAIKEFDVDVSEKICLDIGSSTGGFTDCLLQYGAKLVYAVDVGHLQMHEKLRK
HCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCC
DPRVMLFEDTDIRVFKKPDDIDFDIVTVDVSFISLKKIGEYIKNLCSYYTKLLMLVKPQF
CCCEEEEECCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ELSPKYLKKGIVKDDSAKMLALESVISHFESIGFELLAYTKARPKGTKGNEEFFTYFILK
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCEEEEEEEE
DYNKTK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730486 [H]