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The map label for this gene is mrdA [H]

Identifier: 195952756

GI number: 195952756

Start: 332692

End: 334452

Strand: Direct

Name: mrdA [H]

Synonym: HY04AAS1_0378

Alternate gene names: 195952756

Gene position: 332692-334452 (Clockwise)

Preceding gene: 195952755

Following gene: 195952757

Centisome position: 21.33

GC content: 34.58

Gene sequence:

>1761_bases
ATGAAGAAAAATTACATTGTTTTTGCGCTTTTAATATTATTAGCTTATATTGCAATAGGTGCTAGATTATTTTATTTACA
GATAATAAAAGGAGATAAGTATTACAAAGAGTCTAAACGAAATTATACCAGGCTTCAAATACTTTATCCTCCAAGAGGTG
CTATAGAAAGTTCAGATGGCACAAAGCTTGCCTATGACGTTCCCACCTACGATTTTTATATAGATCCTCAAGAAATATCT
GAAAATAAAGATTTATCGAAAGAGATAGAAAGATTTAAAAACATGTTTGGTATAGATATAACTAATATTATCAAAGTAAA
TAAAAATTCTATAACACCTATAAAAATTATGGATAACCTAAGCACTCAACAGCTGGAAACATTTTATGCAAATTCTTATA
AATTTCCAGGTATTTTTGTTGGCATAGTACCAAAAAGGATATACCCTTATGGAGATGAATACGCTCATATATTAGGTTAT
GTAGGTTTGCCATCTCAGAAAGATCTAAAAGAATATCAGATAGGTCCTCAAAGCCTTGTAGGGAAAGCTGGTATTGAAAA
ACGATTCAACAAATATCTTATAGGTGAGCTCGGTTATAAAAAAATAATGGTGAATGCTTTAGGAAAAGAGCTATACACTA
TTGATAAAGAATTACCCGTACAGGGTGATACAGTGGTACTTACTATAAACTCTCAGATTCAAGATATAGTGCATAATGTG
TTTTTAAACTCTGGTCAGAAAGTGGGTGCAGTTATAGTTATGAATGCTCATAGCGGTGAAATATTAGCATTGGATAGTTT
TCCTGAATACAATCCAAACGATGTATATAAAGACTGGAATAAGATTATAAACAATTCTCTGAGGCCCTTTTTAAATAGAG
CCACTGAGGCCATATATCCACCCGGTTCTGTTTTTAAGGTGCCTATTGCAATAGCCGCCTTAAAATACGGTGTTATAACT
CCATCTTCCACCCTTGATTGCTCTGGGTACATTAAAGTAGGTAATCACATTTTTTACAATTGGCTTAGATACGATACAGG
GTATCAGACAATAGTTCAAGCTATACAAAACTCTTGTGATACGTTCTTTTATCAACTTGGTATGAAGCTCGGTCAAAGGA
AGATATACCAAATAGAAAAAGACTTTGGATATGGCTCTAGTATACCTTTTGAACTTTACAACTCTCCTGGGTTTTTACCT
ACTAAAAGCTGGAAACTAAAGAAATTTCATCAGCCTTGGTATGAAGGCGATACGGTTAACATGAGTATAGGTCAAGGTTA
TGTATTGGTGACTCTTCTTCAGCAAGTTACTATGATGGAGGGTATAGCAAACAACGGCGTGATATATCAACCCACCTTGC
TAAAAGATATCAAAACTCCAGATGGAAAGATTGTATTTGAGAATCACCGTAAGGTTTACAAATACGTAAGAGCTCCTTTA
GAAGACTATTCGGTAGTTAAAAAAGGTTTAAGGGAAGTGGTTGTAAAGGGTACTGGTACAAATGCATTTTCTACTATTGT
AGATATAGCAGGTAAAACTGGTACAGCTCAGGTGGTCTTTGGAAAACACGTAGGACCAAACAGCCCATGGAAATATCAAC
CGGATGCCTGGTTTGTGGGTTTTGCACCGTATAGAGATCCTAAGTATGTGGTGGGTGTTATAGTAGAGCATGGTATTGAA
GGAAATCTCACGGCTGCTCCTATTGTAAAAAGGATATTGGAACAAATATATATAAAAGGTATAAATAGAGAAATAAACTA
A

Upstream 100 bases:

>100_bases
TGAAGTACCATTATATTGATTTTGGATTTTTAAGTTTTTTCATGTCAATTTTTATAGATTGTATAATATTTTTTGTGTTA
GATAGGTTTTATAAAAATGT

Downstream 100 bases:

>100_bases
CTTTATATGCTATAATATTTTTTGTGAGAAAATTAACGTTAATTTTTGTTGTTATATCTAGTATTTTGCTATTTTCTTGT
GAAAAGCCAGTAAACCCAAG

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MKKNYIVFALLILLAYIAIGARLFYLQIIKGDKYYKESKRNYTRLQILYPPRGAIESSDGTKLAYDVPTYDFYIDPQEIS
ENKDLSKEIERFKNMFGIDITNIIKVNKNSITPIKIMDNLSTQQLETFYANSYKFPGIFVGIVPKRIYPYGDEYAHILGY
VGLPSQKDLKEYQIGPQSLVGKAGIEKRFNKYLIGELGYKKIMVNALGKELYTIDKELPVQGDTVVLTINSQIQDIVHNV
FLNSGQKVGAVIVMNAHSGEILALDSFPEYNPNDVYKDWNKIINNSLRPFLNRATEAIYPPGSVFKVPIAIAALKYGVIT
PSSTLDCSGYIKVGNHIFYNWLRYDTGYQTIVQAIQNSCDTFFYQLGMKLGQRKIYQIEKDFGYGSSIPFELYNSPGFLP
TKSWKLKKFHQPWYEGDTVNMSIGQGYVLVTLLQQVTMMEGIANNGVIYQPTLLKDIKTPDGKIVFENHRKVYKYVRAPL
EDYSVVKKGLREVVVKGTGTNAFSTIVDIAGKTGTAQVVFGKHVGPNSPWKYQPDAWFVGFAPYRDPKYVVGVIVEHGIE
GNLTAAPIVKRILEQIYIKGINREIN

Sequences:

>Translated_586_residues
MKKNYIVFALLILLAYIAIGARLFYLQIIKGDKYYKESKRNYTRLQILYPPRGAIESSDGTKLAYDVPTYDFYIDPQEIS
ENKDLSKEIERFKNMFGIDITNIIKVNKNSITPIKIMDNLSTQQLETFYANSYKFPGIFVGIVPKRIYPYGDEYAHILGY
VGLPSQKDLKEYQIGPQSLVGKAGIEKRFNKYLIGELGYKKIMVNALGKELYTIDKELPVQGDTVVLTINSQIQDIVHNV
FLNSGQKVGAVIVMNAHSGEILALDSFPEYNPNDVYKDWNKIINNSLRPFLNRATEAIYPPGSVFKVPIAIAALKYGVIT
PSSTLDCSGYIKVGNHIFYNWLRYDTGYQTIVQAIQNSCDTFFYQLGMKLGQRKIYQIEKDFGYGSSIPFELYNSPGFLP
TKSWKLKKFHQPWYEGDTVNMSIGQGYVLVTLLQQVTMMEGIANNGVIYQPTLLKDIKTPDGKIVFENHRKVYKYVRAPL
EDYSVVKKGLREVVVKGTGTNAFSTIVDIAGKTGTAQVVFGKHVGPNSPWKYQPDAWFVGFAPYRDPKYVVGVIVEHGIE
GNLTAAPIVKRILEQIYIKGINREIN
>Mature_586_residues
MKKNYIVFALLILLAYIAIGARLFYLQIIKGDKYYKESKRNYTRLQILYPPRGAIESSDGTKLAYDVPTYDFYIDPQEIS
ENKDLSKEIERFKNMFGIDITNIIKVNKNSITPIKIMDNLSTQQLETFYANSYKFPGIFVGIVPKRIYPYGDEYAHILGY
VGLPSQKDLKEYQIGPQSLVGKAGIEKRFNKYLIGELGYKKIMVNALGKELYTIDKELPVQGDTVVLTINSQIQDIVHNV
FLNSGQKVGAVIVMNAHSGEILALDSFPEYNPNDVYKDWNKIINNSLRPFLNRATEAIYPPGSVFKVPIAIAALKYGVIT
PSSTLDCSGYIKVGNHIFYNWLRYDTGYQTIVQAIQNSCDTFFYQLGMKLGQRKIYQIEKDFGYGSSIPFELYNSPGFLP
TKSWKLKKFHQPWYEGDTVNMSIGQGYVLVTLLQQVTMMEGIANNGVIYQPTLLKDIKTPDGKIVFENHRKVYKYVRAPL
EDYSVVKKGLREVVVKGTGTNAFSTIVDIAGKTGTAQVVFGKHVGPNSPWKYQPDAWFVGFAPYRDPKYVVGVIVEHGIE
GNLTAAPIVKRILEQIYIKGINREIN

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=619, Percent_Identity=29.0791599353796, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1786272, Length=560, Percent_Identity=25, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66388; Mature: 66388

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNYIVFALLILLAYIAIGARLFYLQIIKGDKYYKESKRNYTRLQILYPPRGAIESSDG
CCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHCCCCEEEEEEECCCCCCCCCCC
TKLAYDVPTYDFYIDPQEISENKDLSKEIERFKNMFGIDITNIIKVNKNSITPIKIMDNL
CEEEEECCCEEEEECHHHHCCCCCHHHHHHHHHHHCCCCEEHEEEECCCCCCEEEEECCC
STQQLETFYANSYKFPGIFVGIVPKRIYPYGDEYAHILGYVGLPSQKDLKEYQIGPQSLV
CHHHHHHHHHCCCCCCEEEEEEECHHCCCCCCCHHHHHEECCCCCCCCHHHHCCCHHHHH
GKAGIEKRFNKYLIGELGYKKIMVNALGKELYTIDKELPVQGDTVVLTINSQIQDIVHNV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCCCCEEEEEECHHHHHHHHHH
FLNSGQKVGAVIVMNAHSGEILALDSFPEYNPNDVYKDWNKIINNSLRPFLNRATEAIYP
HHCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCC
PGSVFKVPIAIAALKYGVITPSSTLDCSGYIKVGNHIFYNWLRYDTGYQTIVQAIQNSCD
CCCEEEHHHHHHHHHHCEECCCCCCCCCCEEEECCEEEEEHHEECCCHHHHHHHHHHHHH
TFFYQLGMKLGQRKIYQIEKDFGYGSSIPFELYNSPGFLPTKSWKLKKFHQPWYEGDTVN
HHHHHHHHHHCCHHHEEEECCCCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCCEEE
MSIGQGYVLVTLLQQVTMMEGIANNGVIYQPTLLKDIKTPDGKIVFENHRKVYKYVRAPL
EECCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCEEEECCHHHHHHHHHCCH
EDYSVVKKGLREVVVKGTGTNAFSTIVDIAGKTGTAQVVFGKHVGPNSPWKYQPDAWFVG
HHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEE
FAPYRDPKYVVGVIVEHGIEGNLTAAPIVKRILEQIYIKGINREIN
ECCCCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKNYIVFALLILLAYIAIGARLFYLQIIKGDKYYKESKRNYTRLQILYPPRGAIESSDG
CCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHCCCCEEEEEEECCCCCCCCCCC
TKLAYDVPTYDFYIDPQEISENKDLSKEIERFKNMFGIDITNIIKVNKNSITPIKIMDNL
CEEEEECCCEEEEECHHHHCCCCCHHHHHHHHHHHCCCCEEHEEEECCCCCCEEEEECCC
STQQLETFYANSYKFPGIFVGIVPKRIYPYGDEYAHILGYVGLPSQKDLKEYQIGPQSLV
CHHHHHHHHHCCCCCCEEEEEEECHHCCCCCCCHHHHHEECCCCCCCCHHHHCCCHHHHH
GKAGIEKRFNKYLIGELGYKKIMVNALGKELYTIDKELPVQGDTVVLTINSQIQDIVHNV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCCCCEEEEEECHHHHHHHHHH
FLNSGQKVGAVIVMNAHSGEILALDSFPEYNPNDVYKDWNKIINNSLRPFLNRATEAIYP
HHCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCC
PGSVFKVPIAIAALKYGVITPSSTLDCSGYIKVGNHIFYNWLRYDTGYQTIVQAIQNSCD
CCCEEEHHHHHHHHHHCEECCCCCCCCCCEEEECCEEEEEHHEECCCHHHHHHHHHHHHH
TFFYQLGMKLGQRKIYQIEKDFGYGSSIPFELYNSPGFLPTKSWKLKKFHQPWYEGDTVN
HHHHHHHHHHCCHHHEEEECCCCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCCEEE
MSIGQGYVLVTLLQQVTMMEGIANNGVIYQPTLLKDIKTPDGKIVFENHRKVYKYVRAPL
EECCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCEEEECCHHHHHHHHHCCH
EDYSVVKKGLREVVVKGTGTNAFSTIVDIAGKTGTAQVVFGKHVGPNSPWKYQPDAWFVG
HHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEE
FAPYRDPKYVVGVIVEHGIEGNLTAAPIVKRILEQIYIKGINREIN
ECCCCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]