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The map label for this gene is adk

Identifier: 195952664

GI number: 195952664

Start: 251195

End: 251830

Strand: Direct

Name: adk

Synonym: HY04AAS1_0286

Alternate gene names: 195952664

Gene position: 251195-251830 (Clockwise)

Preceding gene: 195952663

Following gene: 195952665

Centisome position: 16.11

GC content: 35.85

Gene sequence:

>636_bases
ATGATTTTGGTGTTGTTGGGTCCTCCTGGTTCTGGTAAAGGTACGCAAGGGGCTCTTTTGAAAAGTGAGCTTAGTTTTGA
GCACATATCTACTGGTGATATGCTAAGAGCAGAAGTCTCTAAGAAATCTCCTCTTGGTCTAAAGGCTGAAGAGTATATGA
AGCAGGGACTTTTGGTGCCGGATGATTTAATTATAGCTATGATAAAAAATATTTTAACTGAGGCTCCTCATAAAAATTAT
GTTTTTGATGGGTTTCCAAGAAATGTAAATCAGGCAGAAGCTTTTGAAACAATGCTTAATACTATGAGGCTACAAGTGGA
TAAGGTGTTTTACTTTGATTTAGAGGATGATGTTATTATAAAACGTCTTTCTGGTAGAAGAGTATGTCCAAAGTGCGGTG
CCACTTACAATATTTATTATCAAAAGCCAAAGAATGATACTCTATGCGATAACGATGCCACACCTCTAATTCAAAGAGAT
GATGACAAGGAAGAGGTTATAGTAAATAGATTGAGAGTTTACAAAGAACAAACCTTCCCGCTCATAGAGTATTATAAATA
TAAAAACAAGCTTTTTGTAGTGTCTGCTGATGGTACTCAGGAAGAGGTCTTCGAAAAACTAAAAAGTATGTTATGA

Upstream 100 bases:

>100_bases
CCACCGCTCTTATAGTGGTTGGAGTAGCCTTAGATACTCTAAATCAAATAGATGCTCAAATAATAACTAAAAAGTATAAA
GCTTATACGAGGAAAAAGTG

Downstream 100 bases:

>100_bases
TAGAGCTTTATTCAAAATCTGAGATAGAAAAGATAAAAAAAGCTTGTCAAATAGTTAGTGATGTGCTAAAATATATAGCT
TCTATGGTAAAACCAGGAGT

Product: Nucleoside-triphosphate--adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MILVLLGPPGSGKGTQGALLKSELSFEHISTGDMLRAEVSKKSPLGLKAEEYMKQGLLVPDDLIIAMIKNILTEAPHKNY
VFDGFPRNVNQAEAFETMLNTMRLQVDKVFYFDLEDDVIIKRLSGRRVCPKCGATYNIYYQKPKNDTLCDNDATPLIQRD
DDKEEVIVNRLRVYKEQTFPLIEYYKYKNKLFVVSADGTQEEVFEKLKSML

Sequences:

>Translated_211_residues
MILVLLGPPGSGKGTQGALLKSELSFEHISTGDMLRAEVSKKSPLGLKAEEYMKQGLLVPDDLIIAMIKNILTEAPHKNY
VFDGFPRNVNQAEAFETMLNTMRLQVDKVFYFDLEDDVIIKRLSGRRVCPKCGATYNIYYQKPKNDTLCDNDATPLIQRD
DDKEEVIVNRLRVYKEQTFPLIEYYKYKNKLFVVSADGTQEEVFEKLKSML
>Mature_211_residues
MILVLLGPPGSGKGTQGALLKSELSFEHISTGDMLRAEVSKKSPLGLKAEEYMKQGLLVPDDLIIAMIKNILTEAPHKNY
VFDGFPRNVNQAEAFETMLNTMRLQVDKVFYFDLEDDVIIKRLSGRRVCPKCGATYNIYYQKPKNDTLCDNDATPLIQRD
DDKEEVIVNRLRVYKEQTFPLIEYYKYKNKLFVVSADGTQEEVFEKLKSML

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=39.5121951219512, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=39.5121951219512, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=35.8585858585859, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=34.6938775510204, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=34.6938775510204, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=34.6938775510204, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=34.6938775510204, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=31.6037735849057, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=29.3269230769231, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=29.3269230769231, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=26.5116279069767, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=40.3225806451613, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17552384, Length=195, Percent_Identity=37.4358974358974, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=29.6116504854369, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=30.0469483568075, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.4038461538462, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=186, Percent_Identity=38.7096774193548, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=38.423645320197, Blast_Score=128, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=29.9065420560748, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=41.1483253588517, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=38.8888888888889, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=38.8888888888889, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=29.2682926829268, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=29.2682926829268, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=26.0663507109005, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=26.0663507109005, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_HYDS0 (B4U765)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002120954.1
- ProteinModelPortal:   B4U765
- GeneID:   6743080
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0286
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24126; Mature: 24126

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVLLGPPGSGKGTQGALLKSELSFEHISTGDMLRAEVSKKSPLGLKAEEYMKQGLLVP
CEEEEECCCCCCCCCCCCHHHHHCCHHHCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCC
DDLIIAMIKNILTEAPHKNYVFDGFPRNVNQAEAFETMLNTMRLQVDKVFYFDLEDDVII
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCHHHH
KRLSGRRVCPKCGATYNIYYQKPKNDTLCDNDATPLIQRDDDKEEVIVNRLRVYKEQTFP
HHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCC
LIEYYKYKNKLFVVSADGTQEEVFEKLKSML
HHHHEEECCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MILVLLGPPGSGKGTQGALLKSELSFEHISTGDMLRAEVSKKSPLGLKAEEYMKQGLLVP
CEEEEECCCCCCCCCCCCHHHHHCCHHHCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCC
DDLIIAMIKNILTEAPHKNYVFDGFPRNVNQAEAFETMLNTMRLQVDKVFYFDLEDDVII
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCHHHH
KRLSGRRVCPKCGATYNIYYQKPKNDTLCDNDATPLIQRDDDKEEVIVNRLRVYKEQTFP
HHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCC
LIEYYKYKNKLFVVSADGTQEEVFEKLKSML
HHHHEEECCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA