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The map label for this gene is lpxD [H]

Identifier: 195952580

GI number: 195952580

Start: 176922

End: 177896

Strand: Direct

Name: lpxD [H]

Synonym: HY04AAS1_0200

Alternate gene names: 195952580

Gene position: 176922-177896 (Clockwise)

Preceding gene: 195952579

Following gene: 195952590

Centisome position: 11.34

GC content: 36.31

Gene sequence:

>975_bases
ATGAAATTATCTGAAATAGCCTCCTTGCTTGGGGGCATTTCAAGCTATACCGTTGATATAGATGTTGTTGGCGTTAGTTC
TGTTTTATCTCAAAAGCCAAATACCATAGTGTTTGTAGATGAAAAACATAAAGATATAGATTTCAAACAAGACATTGCTT
ACCTATCTGATATAGATTTACAAGCGCCAAACTTTATAAAGGTGCAAAATTTAAAGTATGCAATGGCTATAGTCCTTGAT
ACTTTTTATAAAAGCGAAAAACCAAAAGGTATATCGGACAAAGCTTTTATAGAAGAGAGTGTACATATTGACAAAGACGT
TTATATAGGGCCCTTTTCTTATATAGGCAAAAACGTAAGCTTAGGAGAAGGAGTGCTAATATATCCTTTTACTTACGTGG
GAGACAACACCATTATAGGGGATAACAGCATTTTGTATAGCGGAGTTCATATATACAAAAATACCGTTATAGGTAAAAAT
GTAATAATACATTCAGGGGCTGTAATAGGAGCGGATGGATTTGGATACGCTATAGGACCAGAAGGTATAAAAAAGCTAAA
TCATATAGGAAACGTTATCATAGAAGATAATGTAGAGATAGGGGCAAACACCACTATAGATAGGTCGCTTCTTGATAGCA
CAATCATAGGTAAATCTACAAAGATAGACAACCTTGTAATGGTAGGACACAATTGTAAGATAGGGCAAAACTGCTTTTTG
GTATCTCAAGTGGGGCTTTCGGGTAGCGTCAATATAGGGGATAATTCAATACTTGCTGGACAAGTGGGAGTTGCAGATCA
CGTAAACATAGGCTCAAACGTACAAGTAGCAGCCAAATCGGGCGTTGCCTACGATCTTCCTTCTAACAACACTTACGGTG
CAAACCTACCATCTATAGAATGGAACAAGTGGAAAAGAATTTACGTATCTTTGTTAAAACTTCCAGATGCCTTAAAGAAG
CTAAACAAACTTTAA

Upstream 100 bases:

>100_bases
CTCATAGCTTAGAAGGCGTCTTTGATTGCAATCAAATGCTATATACTGGTAATCTTGATATAACACCATCTATTATAAAA
GCCTTAGATAGCGCACACAA

Downstream 100 bases:

>100_bases
AACCAGTTTGCTCTTTGTATATCAAAAACTCTTTTTAAAGCGTAAAAGCTCATAAATACATATATCACTACAAAAAATAA
GGGATTCATATTTATTTTGG

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKLSEIASLLGGISSYTVDIDVVGVSSVLSQKPNTIVFVDEKHKDIDFKQDIAYLSDIDLQAPNFIKVQNLKYAMAIVLD
TFYKSEKPKGISDKAFIEESVHIDKDVYIGPFSYIGKNVSLGEGVLIYPFTYVGDNTIIGDNSILYSGVHIYKNTVIGKN
VIIHSGAVIGADGFGYAIGPEGIKKLNHIGNVIIEDNVEIGANTTIDRSLLDSTIIGKSTKIDNLVMVGHNCKIGQNCFL
VSQVGLSGSVNIGDNSILAGQVGVADHVNIGSNVQVAAKSGVAYDLPSNNTYGANLPSIEWNKWKRIYVSLLKLPDALKK
LNKL

Sequences:

>Translated_324_residues
MKLSEIASLLGGISSYTVDIDVVGVSSVLSQKPNTIVFVDEKHKDIDFKQDIAYLSDIDLQAPNFIKVQNLKYAMAIVLD
TFYKSEKPKGISDKAFIEESVHIDKDVYIGPFSYIGKNVSLGEGVLIYPFTYVGDNTIIGDNSILYSGVHIYKNTVIGKN
VIIHSGAVIGADGFGYAIGPEGIKKLNHIGNVIIEDNVEIGANTTIDRSLLDSTIIGKSTKIDNLVMVGHNCKIGQNCFL
VSQVGLSGSVNIGDNSILAGQVGVADHVNIGSNVQVAAKSGVAYDLPSNNTYGANLPSIEWNKWKRIYVSLLKLPDALKK
LNKL
>Mature_324_residues
MKLSEIASLLGGISSYTVDIDVVGVSSVLSQKPNTIVFVDEKHKDIDFKQDIAYLSDIDLQAPNFIKVQNLKYAMAIVLD
TFYKSEKPKGISDKAFIEESVHIDKDVYIGPFSYIGKNVSLGEGVLIYPFTYVGDNTIIGDNSILYSGVHIYKNTVIGKN
VIIHSGAVIGADGFGYAIGPEGIKKLNHIGNVIIEDNVEIGANTTIDRSLLDSTIIGKSTKIDNLVMVGHNCKIGQNCFL
VSQVGLSGSVNIGDNSILAGQVGVADHVNIGSNVQVAAKSGVAYDLPSNNTYGANLPSIEWNKWKRIYVSLLKLPDALKK
LNKL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=333, Percent_Identity=34.2342342342342, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786378, Length=227, Percent_Identity=28.1938325991189, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: 2.3.1.-

Molecular weight: Translated: 34963; Mature: 34963

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSEIASLLGGISSYTVDIDVVGVSSVLSQKPNTIVFVDEKHKDIDFKQDIAYLSDIDL
CCHHHHHHHHCCCCEEEEEEEEEEHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
QAPNFIKVQNLKYAMAIVLDTFYKSEKPKGISDKAFIEESVHIDKDVYIGPFSYIGKNVS
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHCCCCC
LGEGVLIYPFTYVGDNTIIGDNSILYSGVHIYKNTVIGKNVIIHSGAVIGADGFGYAIGP
CCCCEEEEEEEEECCCEEECCCCEEECCEEEEECEECCCEEEEECCEEEECCCCCEEECH
EGIKKLNHIGNVIIEDNVEIGANTTIDRSLLDSTIIGKSTKIDNLVMVGHNCKIGQNCFL
HHHHHHHHHCCEEEECCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEE
VSQVGLSGSVNIGDNSILAGQVGVADHVNIGSNVQVAAKSGVAYDLPSNNTYGANLPSIE
EEECCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCC
WNKWKRIYVSLLKLPDALKKLNKL
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLSEIASLLGGISSYTVDIDVVGVSSVLSQKPNTIVFVDEKHKDIDFKQDIAYLSDIDL
CCHHHHHHHHCCCCEEEEEEEEEEHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
QAPNFIKVQNLKYAMAIVLDTFYKSEKPKGISDKAFIEESVHIDKDVYIGPFSYIGKNVS
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEECCHHHHCCCCC
LGEGVLIYPFTYVGDNTIIGDNSILYSGVHIYKNTVIGKNVIIHSGAVIGADGFGYAIGP
CCCCEEEEEEEEECCCEEECCCCEEECCEEEEECEECCCEEEEECCEEEECCCCCEEECH
EGIKKLNHIGNVIIEDNVEIGANTTIDRSLLDSTIIGKSTKIDNLVMVGHNCKIGQNCFL
HHHHHHHHHCCEEEECCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEE
VSQVGLSGSVNIGDNSILAGQVGVADHVNIGSNVQVAAKSGVAYDLPSNNTYGANLPSIE
EEECCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCC
WNKWKRIYVSLLKLPDALKKLNKL
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]