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The map label for this gene is ilvC

Identifier: 195952445

GI number: 195952445

Start: 61362

End: 62363

Strand: Direct

Name: ilvC

Synonym: HY04AAS1_0065

Alternate gene names: 195952445

Gene position: 61362-62363 (Clockwise)

Preceding gene: 195952444

Following gene: 195952446

Centisome position: 3.93

GC content: 39.72

Gene sequence:

>1002_bases
ATGGCGAAAATTTACTACGACGAAGATGCATCTTTGGGTATCTTGGCTATGAAAACTGTAGCCATAGTGGGTTATGGTTC
TCAAGGACACGCTCATGCTTTAAATCTAAGAGACAGTGGTATTAGGGTTATAGTGGCTTTAGACGATAAAAGTCCTCATA
GAAAAACTGCTATGGAAGATGGTTTTAGCGTATATACCACCTCTAGAGCAACTCAAGAGGCCGATGTGATAATGATATTA
ACACCAGACACGGTTCAACCAGCTGTATATAAAGAATGCATAGAACCTAATTTAACACCTGGAAAAGCTATAGCCTTTGC
CCATGGTTTTAACATACATTTTGGTCAAATAGTGCCACCAAAAGATATAGATGTATTTATGGTGGCTCCAAAAGGACCAG
GCCATTTGGTAAGATGGATGTACGAAGAGGGAAAAGGAGTACCAGCTCTTATATCTATACATCAAGATGCTACAGGTTCT
TGTAGAGATATAGCCTTAGCTTATGCAAAAGGCATAGGTGCTACAAGGGCTGGGGTTATAGAAACCACGTTTAGAGAAGA
AACGGAAACAGACTTATTTGGTGAGCAAGCGGTGCTTTGTGGTGGTGCTACAGCCCTTATAAAAGCTGGTTTTGAAACGC
TTGTAGAGGCCGGTTATCAACCAGAGATGGCTTATTTTGAATGTCTTCATGAGTTAAAGCTAATAGTAGACCTCATATAC
CAACACGGCATAGCTGGTATGAGATATTCTATATCAGATACCGCAAAATATGGCGATGTAACAAGAGGTGATAGAGTATA
CGAAGCTGTCAAACCTCTTATGAAACAGATGCTCAAAGAAATTCAAGATGGTGAGTTTGCCAGAGAATGGATATTGGAAA
ATCAAGCCAACAGACCAGTTTACAACGCTCTTTTAAATAAGGATAAAGAACATTTGGTGGAAAAAGTTGGTAAAGAGCTA
AGACAGATGATGCCGTGGCTATCTGGTAAAGAGTTAAAATGA

Upstream 100 bases:

>100_bases
TAAGATAAGCCAAAGCTTATAGAAAAATAACAATTTTTCATAGCACAAACAATCTCAATAGGTTAAAATAAAAGATATTA
GCTATTTGGAGGTAAAATAA

Downstream 100 bases:

>100_bases
ATCTTACCAAAAAACGTTATAAACTAAAAAAGTTTTACGCTCCCATGGGGCATGTGTTTGTAAAGATGCACATGTCCCCA
AACGTAATAACCCTTTTGTC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MAKIYYDEDASLGILAMKTVAIVGYGSQGHAHALNLRDSGIRVIVALDDKSPHRKTAMEDGFSVYTTSRATQEADVIMIL
TPDTVQPAVYKECIEPNLTPGKAIAFAHGFNIHFGQIVPPKDIDVFMVAPKGPGHLVRWMYEEGKGVPALISIHQDATGS
CRDIALAYAKGIGATRAGVIETTFREETETDLFGEQAVLCGGATALIKAGFETLVEAGYQPEMAYFECLHELKLIVDLIY
QHGIAGMRYSISDTAKYGDVTRGDRVYEAVKPLMKQMLKEIQDGEFAREWILENQANRPVYNALLNKDKEHLVEKVGKEL
RQMMPWLSGKELK

Sequences:

>Translated_333_residues
MAKIYYDEDASLGILAMKTVAIVGYGSQGHAHALNLRDSGIRVIVALDDKSPHRKTAMEDGFSVYTTSRATQEADVIMIL
TPDTVQPAVYKECIEPNLTPGKAIAFAHGFNIHFGQIVPPKDIDVFMVAPKGPGHLVRWMYEEGKGVPALISIHQDATGS
CRDIALAYAKGIGATRAGVIETTFREETETDLFGEQAVLCGGATALIKAGFETLVEAGYQPEMAYFECLHELKLIVDLIY
QHGIAGMRYSISDTAKYGDVTRGDRVYEAVKPLMKQMLKEIQDGEFAREWILENQANRPVYNALLNKDKEHLVEKVGKEL
RQMMPWLSGKELK
>Mature_332_residues
AKIYYDEDASLGILAMKTVAIVGYGSQGHAHALNLRDSGIRVIVALDDKSPHRKTAMEDGFSVYTTSRATQEADVIMILT
PDTVQPAVYKECIEPNLTPGKAIAFAHGFNIHFGQIVPPKDIDVFMVAPKGPGHLVRWMYEEGKGVPALISIHQDATGSC
RDIALAYAKGIGATRAGVIETTFREETETDLFGEQAVLCGGATALIKAGFETLVEAGYQPEMAYFECLHELKLIVDLIYQ
HGIAGMRYSISDTAKYGDVTRGDRVYEAVKPLMKQMLKEIQDGEFAREWILENQANRPVYNALLNKDKEHLVEKVGKELR
QMMPWLSGKELK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=328, Percent_Identity=36.280487804878, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=319, Percent_Identity=33.5423197492163, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HYDS0 (B4U6I9)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002120735.1
- ProteinModelPortal:   B4U6I9
- SMR:   B4U6I9
- GeneID:   6742848
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0065
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36838; Mature: 36707

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYYDEDASLGILAMKTVAIVGYGSQGHAHALNLRDSGIRVIVALDDKSPHRKTAMED
CCEEEECCCCCCCHHEEEEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHC
GFSVYTTSRATQEADVIMILTPDTVQPAVYKECIEPNLTPGKAIAFAHGFNIHFGQIVPP
CCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCC
KDIDVFMVAPKGPGHLVRWMYEEGKGVPALISIHQDATGSCRDIALAYAKGIGATRAGVI
CCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHH
ETTFREETETDLFGEQAVLCGGATALIKAGFETLVEAGYQPEMAYFECLHELKLIVDLIY
HHHHHCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QHGIAGMRYSISDTAKYGDVTRGDRVYEAVKPLMKQMLKEIQDGEFAREWILENQANRPV
HCCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
YNALLNKDKEHLVEKVGKELRQMMPWLSGKELK
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AKIYYDEDASLGILAMKTVAIVGYGSQGHAHALNLRDSGIRVIVALDDKSPHRKTAMED
CEEEECCCCCCCHHEEEEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHC
GFSVYTTSRATQEADVIMILTPDTVQPAVYKECIEPNLTPGKAIAFAHGFNIHFGQIVPP
CCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCC
KDIDVFMVAPKGPGHLVRWMYEEGKGVPALISIHQDATGSCRDIALAYAKGIGATRAGVI
CCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHH
ETTFREETETDLFGEQAVLCGGATALIKAGFETLVEAGYQPEMAYFECLHELKLIVDLIY
HHHHHCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QHGIAGMRYSISDTAKYGDVTRGDRVYEAVKPLMKQMLKEIQDGEFAREWILENQANRPV
HCCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
YNALLNKDKEHLVEKVGKELRQMMPWLSGKELK
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA