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The map label for this gene is prs [H]

Identifier: 195952396

GI number: 195952396

Start: 16463

End: 17401

Strand: Direct

Name: prs [H]

Synonym: HY04AAS1_0016

Alternate gene names: 195952396

Gene position: 16463-17401 (Clockwise)

Preceding gene: 195952393

Following gene: 195952403

Centisome position: 1.06

GC content: 38.02

Gene sequence:

>939_bases
ATGGGTATACCGATTAAGCTTATTGCCGGTTCGTCAAATATGAAGTTAGCTCAAGAAATATCTGAATATCTTGATATACC
ATTATCAAAAACACTTCTTAGTAAATTTAGCGATGGTGAGATAAGAGTGCAGGTAGAAGAATCTATGAGAGGTGGAGATA
TATTTGTTATACAATCGTTATCGGCTCCTATAAACGATCACATTATGGAGCTTGTACTACTATTAGATGCTATTAAAAGA
GCGTCTGCTTATCGTATAACCGCTGTAATACCTTATTTTGCCTATGCAAGACAAGATAGAAAAGATAAACCACGTGTTCC
TATAAGCGCTAGAGTGCTGGCTGATATGATTACAACAGCGGGAGCCCAAAGGGCTGTGATAATGGATTTACACTCCCCTC
AAATTCAGGGCTTTTTTAATATACCAGTGGATAATCTCTTGGCTTTACCGGTGCTTTACGATTATATAAAATATAAAGTA
GATTCTCCCAACACTGTTATAGTATCCCCAGATGCTGGTGGTGCTGAAAGGGCAAGGCAGCTTGCCAATAAGCTTGGGTG
CAATATCGCCATCATATACAAAAGAAGACCAGAACCAAATAAAGCGGAAGTATTTGACGTTATAGGAAACGTAGAAGGCA
AAGATGCCATCATAATAGATGACATTATAGATACGGCAGGTACCTTGGTGGCTGCTACCAACATGCTTATAAACAAAGGA
GCAAAATCTGTTAGAGCGCTAACTACTCACGGTGTTTTATCTGGACCAGCATTAGAGCGTATAAACAACTCTATATTAGA
AGAGGTAGTATTAACCAACACCATATGCCAACAAGGTAAAGAATCTAGCAAAATAAACATAGTAAGCATAGCTCCAATAG
TAGGTGAAGCTATAAAGCGTATATATGAAAACTCTTCAGTGAGTTCTTTATTCGTATGA

Upstream 100 bases:

>100_bases
TACTCATATAAAAGTTTATTTACAATAACTTATCTCATAATCATAGAAATTTATTTGGTTTATAATACTAAAATCCTGAA
ACTTTTATAGGAGTTTAGAA

Downstream 100 bases:

>100_bases
TATAATATAAAACCCTTAGGATGGGTGGCCGAGTGGTCGAAGGCGCACCGCTGGAAACGGTGTGAAGGGTGATGAGCTCT
TCCGCGGGTTCGAATCCCGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MGIPIKLIAGSSNMKLAQEISEYLDIPLSKTLLSKFSDGEIRVQVEESMRGGDIFVIQSLSAPINDHIMELVLLLDAIKR
ASAYRITAVIPYFAYARQDRKDKPRVPISARVLADMITTAGAQRAVIMDLHSPQIQGFFNIPVDNLLALPVLYDYIKYKV
DSPNTVIVSPDAGGAERARQLANKLGCNIAIIYKRRPEPNKAEVFDVIGNVEGKDAIIIDDIIDTAGTLVAATNMLINKG
AKSVRALTTHGVLSGPALERINNSILEEVVLTNTICQQGKESSKINIVSIAPIVGEAIKRIYENSSVSSLFV

Sequences:

>Translated_312_residues
MGIPIKLIAGSSNMKLAQEISEYLDIPLSKTLLSKFSDGEIRVQVEESMRGGDIFVIQSLSAPINDHIMELVLLLDAIKR
ASAYRITAVIPYFAYARQDRKDKPRVPISARVLADMITTAGAQRAVIMDLHSPQIQGFFNIPVDNLLALPVLYDYIKYKV
DSPNTVIVSPDAGGAERARQLANKLGCNIAIIYKRRPEPNKAEVFDVIGNVEGKDAIIIDDIIDTAGTLVAATNMLINKG
AKSVRALTTHGVLSGPALERINNSILEEVVLTNTICQQGKESSKINIVSIAPIVGEAIKRIYENSSVSSLFV
>Mature_311_residues
GIPIKLIAGSSNMKLAQEISEYLDIPLSKTLLSKFSDGEIRVQVEESMRGGDIFVIQSLSAPINDHIMELVLLLDAIKRA
SAYRITAVIPYFAYARQDRKDKPRVPISARVLADMITTAGAQRAVIMDLHSPQIQGFFNIPVDNLLALPVLYDYIKYKVD
SPNTVIVSPDAGGAERARQLANKLGCNIAIIYKRRPEPNKAEVFDVIGNVEGKDAIIIDDIIDTAGTLVAATNMLINKGA
KSVRALTTHGVLSGPALERINNSILEEVVLTNTICQQGKESSKINIVSIAPIVGEAIKRIYENSSVSSLFV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=47.0967741935484, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=46.4516129032258, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=46.4516129032258, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=46.0063897763578, Blast_Score=290, Evalue=8e-79,
Organism=Homo sapiens, GI4506133, Length=337, Percent_Identity=38.2789317507418, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI194018537, Length=330, Percent_Identity=37.5757575757576, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=46.474358974359, Blast_Score=287, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=48.7096774193548, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=48.7096774193548, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=48.7096774193548, Blast_Score=296, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=48.3766233766234, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=34.6268656716418, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=47.2491909385113, Blast_Score=284, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=46.1290322580645, Blast_Score=279, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=46.4516129032258, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322667, Length=192, Percent_Identity=43.2291666666667, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=107, Percent_Identity=42.9906542056075, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=47.4193548387097, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=44.1441441441441, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=33.9943342776204, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=33.9943342776204, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=33.9943342776204, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=33.9943342776204, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=32.5268817204301, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=32.5268817204301, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45552010, Length=201, Percent_Identity=38.3084577114428, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33970; Mature: 33839

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPIKLIAGSSNMKLAQEISEYLDIPLSKTLLSKFSDGEIRVQVEESMRGGDIFVIQSL
CCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECC
SAPINDHIMELVLLLDAIKRASAYRITAVIPYFAYARQDRKDKPRVPISARVLADMITTA
CCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GAQRAVIMDLHSPQIQGFFNIPVDNLLALPVLYDYIKYKVDSPNTVIVSPDAGGAERARQ
CCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCHHHHHH
LANKLGCNIAIIYKRRPEPNKAEVFDVIGNVEGKDAIIIDDIIDTAGTLVAATNMLINKG
HHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
AKSVRALTTHGVLSGPALERINNSILEEVVLTNTICQQGKESSKINIVSIAPIVGEAIKR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHH
IYENSSVSSLFV
HHCCCCCCCCCC
>Mature Secondary Structure 
GIPIKLIAGSSNMKLAQEISEYLDIPLSKTLLSKFSDGEIRVQVEESMRGGDIFVIQSL
CCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECC
SAPINDHIMELVLLLDAIKRASAYRITAVIPYFAYARQDRKDKPRVPISARVLADMITTA
CCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GAQRAVIMDLHSPQIQGFFNIPVDNLLALPVLYDYIKYKVDSPNTVIVSPDAGGAERARQ
CCCEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCHHHHHH
LANKLGCNIAIIYKRRPEPNKAEVFDVIGNVEGKDAIIIDDIIDTAGTLVAATNMLINKG
HHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
AKSVRALTTHGVLSGPALERINNSILEEVVLTNTICQQGKESSKINIVSIAPIVGEAIKR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHH
IYENSSVSSLFV
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]