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The map label for this gene is pmrD

Identifier: 194737998

GI number: 194737998

Start: 2417220

End: 2417477

Strand: Reverse

Name: pmrD

Synonym: SeSA_A2532

Alternate gene names: 194737998

Gene position: 2417477-2417220 (Counterclockwise)

Preceding gene: 194734141

Following gene: 194735663

Centisome position: 51.34

GC content: 48.06

Gene sequence:

>258_bases
ATGGAATGGTTGGTTAAGAAATCGCATTATGTCAAAAAGAGGGCGTGCCATGTTCTGGTGCTGTGCGATAGCGGCGGTTC
GCTAAAAATGATCGCCGAGGCGAATTCCATGATATTACTGAGTCCCGGCGATATCCTGTCGCCTTTACAGGATGCGCAGT
ATTGTATTAATCGGGAAAAACACCAGACCTTAAAAATCGTTGATGCACGCTGTTATTCCTGCGACGAATGGCAGCGGTTG
ACGCGCAAGCCTTCATGA

Upstream 100 bases:

>100_bases
TAATGTTAGGTTAATATACAACCATTCCATCGCTATTGCCGTTTTGTTTATCCGTTGATGTGTAACGTGTTATGAACAAT
CAGCGTGAAACGGGGGCGCT

Downstream 100 bases:

>100_bases
TCTGGCGGGCAGAAAAATCAGCATTACCCCCGCCATAATACACAATACGCCGAGCATCGCTTTTAGGCTGAAGGCGCCTT
GCAAACCGGGTAACAGCATT

Product: signal transduction protein PmrD

Products: NA

Alternate protein names: BasR post-transcriptional activator; Polymyxin resistance protein pmrD

Number of amino acids: Translated: 85; Mature: 85

Protein sequence:

>85_residues
MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREKHQTLKIVDARCYSCDEWQRL
TRKPS

Sequences:

>Translated_85_residues
MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREKHQTLKIVDARCYSCDEWQRL
TRKPS
>Mature_85_residues
MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREKHQTLKIVDARCYSCDEWQRL
TRKPS

Specific function: Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pmrD family

Homologues:

Organism=Escherichia coli, GI87082076, Length=79, Percent_Identity=59.4936708860759, Blast_Score=96, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PMRD_SALTY (P37589)

Other databases:

- EMBL:   U02281
- EMBL:   AY775359
- EMBL:   AE006468
- EMBL:   AF036677
- RefSeq:   NP_461246.1
- ProteinModelPortal:   P37589
- SMR:   P37589
- GeneID:   1253826
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2304
- HOGENOM:   HBG467151
- OMA:   NTMEWLV
- ProtClustDB:   PRK15450
- BioCyc:   STYP99287:STM2304-MONOMER
- InterPro:   IPR020146
- ProDom:   PD028730

Pfam domain/function: PF11183 PmrD

EC number: NA

Molecular weight: Translated: 9750; Mature: 9750

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
9.4 %Cys+Met (Translated Protein)
5.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
9.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREK
CCCCCCCHHHHHHCCEEEEEEECCCCCEEEEECCCCEEEECCCHHCCHHHHHHHHHCCCC
HQTLKIVDARCYSCDEWQRLTRKPS
CCEEEEEECCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MEWLVKKSHYVKKRACHVLVLCDSGGSLKMIAEANSMILLSPGDILSPLQDAQYCINREK
CCCCCCCHHHHHHCCEEEEEEECCCCCEEEEECCCCEEEECCCHHCCHHHHHHHHHCCCC
HQTLKIVDARCYSCDEWQRLTRKPS
CCEEEEEECCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8206837; 11677609; 9570402