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The map label for this gene is ltaE [H]

Identifier: 194737433

GI number: 194737433

Start: 1019469

End: 1020470

Strand: Reverse

Name: ltaE [H]

Synonym: SeSA_A1051

Alternate gene names: 194737433

Gene position: 1020470-1019469 (Counterclockwise)

Preceding gene: 194737868

Following gene: 194736876

Centisome position: 21.67

GC content: 59.58

Gene sequence:

>1002_bases
ATGATTGATTTACGCAGTGATACCGTTACCCGACCGGGCCGCGCCATGCTCGAGGCGATGATGACCGCCCCGGTCGGGGA
CGACGTATACGGCGATGACCCTACCGTTAACGCCCTTCAGCGCTACGCCGCCGACCTTTCCGGTAAAGAAGCGGCGCTTT
TTTTACCCACCGGCACCCAGGCCAATCTGGTCGCGCTACTTAGCCATTGTGAACGCGGCGAAGAGTATATCGTCGGTCAA
GGCGCGCATAATTATCTCTATGAAGCTGGCGGCGCTGCGGTGCTCGGCAGCATTCAGCCGCAGCCCATCGACGCCGCCGC
GGACGGTACACTGCCGCTGGAGAACGTGGCGGCGAAGATTAAAGCGGATGACATCCACTTCGCGCGCACGCGCTTGCTCA
GTCTGGAAAATACGCATAACGGGAAAGTGCTGCCGCGCGCGTATCTGAAAGACGCCTGGACATTTACCCGCGAACGTGGA
CTGGCGCTGCACGTTGACGGCGCCCGAATTTTTAACGCGGTGGTTGCCTACGGCTGTGAGTTAAAAGAGATTACGCAGTA
TTGCGACTCTTTTACCATCTGCCTGTCAAAAGGTCTCGGAACGCCGGTCGGTTCGCTGCTGGTCGGCAACCGCGATTACA
TTAAACGCGCGACGCGCTGGCGTAAAATGGTCGGCGGCGGAATGCGTCAGGCCGGGATTCTGGCAGCGGCCGGACTGTAT
GCGCTGAAGCATAACGTGGCGCGTCTGCAAGAGGACCATGATAACGCCGCCTGGCTGGCGCAGCAGCTTCGGGAAGCAGG
TGCGGAGGTCATGCGCCACGAAACGAATATGCTGTTTGTTCGCGTTGGCGAAGCACAGGCCGCCGCGCTTGGCGACTATT
TACGGGAACGGAATATCCTGATTAACGCCGCGCCGATTGTGCGTCTGGTGACGCATCTGGATGTCTCTCGCGAACAGCTT
GCCGACGTCGTCGCCCACTGGCGCGCCTTTTTAGCCCGCTAA

Upstream 100 bases:

>100_bases
CCATTATTAGCGGCCGCGGCGATGAAGTGATCGAACTGGCGAAAACGAACTGGCTAAGGTAAAACAGTGCACATCACCTT
TTAAAATCCAGGGATGTGCC

Downstream 100 bases:

>100_bases
GGAGAGCAACGTGGCGCAACGCATTCTGGTTCTCGGCGCCAGCGGCTATATCGGCCAGCACCTGGTCTGTGCGCTAAGTC
AGCAAGGGCATCAGGTGCGG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDLRSDTVTRPGRAMLEAMMTAPVGDDVYGDDPTVNALQRYAADLSGKEAALFLPTGTQANLVALLSHCERGEEYIVGQ
GAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLENVAAKIKADDIHFARTRLLSLENTHNGKVLPRAYLKDAWTFTRERG
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRATRWRKMVGGGMRQAGILAAAGLY
ALKHNVARLQEDHDNAAWLAQQLREAGAEVMRHETNMLFVRVGEAQAAALGDYLRERNILINAAPIVRLVTHLDVSREQL
ADVVAHWRAFLAR

Sequences:

>Translated_333_residues
MIDLRSDTVTRPGRAMLEAMMTAPVGDDVYGDDPTVNALQRYAADLSGKEAALFLPTGTQANLVALLSHCERGEEYIVGQ
GAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLENVAAKIKADDIHFARTRLLSLENTHNGKVLPRAYLKDAWTFTRERG
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRATRWRKMVGGGMRQAGILAAAGLY
ALKHNVARLQEDHDNAAWLAQQLREAGAEVMRHETNMLFVRVGEAQAAALGDYLRERNILINAAPIVRLVTHLDVSREQL
ADVVAHWRAFLAR
>Mature_333_residues
MIDLRSDTVTRPGRAMLEAMMTAPVGDDVYGDDPTVNALQRYAADLSGKEAALFLPTGTQANLVALLSHCERGEEYIVGQ
GAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLENVAAKIKADDIHFARTRLLSLENTHNGKVLPRAYLKDAWTFTRERG
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRATRWRKMVGGGMRQAGILAAAGLY
ALKHNVARLQEDHDNAAWLAQQLREAGAEVMRHETNMLFVRVGEAQAAALGDYLRERNILINAAPIVRLVTHLDVSREQL
ADVVAHWRAFLAR

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=333, Percent_Identity=89.1891891891892, Blast_Score=623, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.3294797687861, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.3294797687861, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.3294797687861, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6320789, Length=327, Percent_Identity=37.6146788990826, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355439, Length=305, Percent_Identity=44.2622950819672, Blast_Score=247, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36342; Mature: 36342

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRSDTVTRPGRAMLEAMMTAPVGDDVYGDDPTVNALQRYAADLSGKEAALFLPTGTQ
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCC
ANLVALLSHCERGEEYIVGQGAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLENVAAKI
HHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHH
KADDIHFARTRLLSLENTHNGKVLPRAYLKDAWTFTRERGLALHVDGARIFNAVVAYGCE
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
LKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRATRWRKMVGGGMRQAGILAAAGLY
HHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALKHNVARLQEDHDNAAWLAQQLREAGAEVMRHETNMLFVRVGEAQAAALGDYLRERNIL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCEE
INAAPIVRLVTHLDVSREQLADVVAHWRAFLAR
EEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDLRSDTVTRPGRAMLEAMMTAPVGDDVYGDDPTVNALQRYAADLSGKEAALFLPTGTQ
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCC
ANLVALLSHCERGEEYIVGQGAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLENVAAKI
HHHHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHH
KADDIHFARTRLLSLENTHNGKVLPRAYLKDAWTFTRERGLALHVDGARIFNAVVAYGCE
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
LKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRATRWRKMVGGGMRQAGILAAAGLY
HHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALKHNVARLQEDHDNAAWLAQQLREAGAEVMRHETNMLFVRVGEAQAAALGDYLRERNIL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCEE
INAAPIVRLVTHLDVSREQLADVVAHWRAFLAR
EEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]