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The map label for this gene is nuoL [H]

Identifier: 194737362

GI number: 194737362

Start: 2430760

End: 2432595

Strand: Reverse

Name: nuoL [H]

Synonym: SeSA_A2546

Alternate gene names: 194737362

Gene position: 2432595-2430760 (Counterclockwise)

Preceding gene: 194737469

Following gene: 194736746

Centisome position: 51.66

GC content: 58.06

Gene sequence:

>1836_bases
ATGCTTGCCTTAACCATTATTCTGCCATTGATTGGCTTTGTACTGCTGGCGTTCTCTCGCGGACGCTGGTCGGAAAATCT
CTCCGCGACCATTGGCGTGGGCTCCGTTGGTCTGGCGGCGTTGGTGACAGCGTTTGTCGGGATGGATTTCTTCGCCAACG
GCAAACAGGCGTTCAGCCAGCCGCTGTGGACGTGGATGTCGGTCGGTAACTTCAACATCGGTTTTAACCTGGTGCTGGAC
GGCCTGTCGCTGACCATGCTCTCTGTGGTCACCGGCGTCGGCTTCCTGATCCACATGTTCGCGTCCTGGTACATGCGTGG
AGAAGAGGGTTACTCCCGCTTCTTCGCTTATACCAACCTGTTTATCGCCAGCATGGTTGTTCTGGTGCTGTCCGATAACC
TGCTGTTGATGTACCTCGGCTGGGAAGGCGTGGGCCTGTGCTCTTATCTGTTGATCGGCTTCTATTACAGCGATCCGAAG
AATGGCGCAGCGGCAATGAAAGCCTTCGTGGTGACCCGTGTCGGTGACGTATTCCTCGCCTTCGCGCTGTTCATCCTCTA
CAACGAACTGGGCACGCTGAACTTCCGCGAAATGGTCGAGCTGGCGCCAGCGCACTTTGCTGACGGCAACAACATGCTGA
TGTGGGCGACGCTGATGCTGCTGGGCGGCGCGGTCGGTAAATCTGCGCAGCTTCCGTTGCAGACCTGGCTTGCCGACGCG
ATGGCCGGCCCGACGCCGGTCTCCGCGCTGATCCACGCCGCTACCATGGTGACCGCCGGTGTCTACCTGATCGCTCGTAC
CCATGGTTTGTTCCTGATGACCCCGGAAATTCTGCATCTGGTGGGCATTATCGGGGCGATTACGTTGGTCATGGCGGGTT
TCGCCGCGCTGGTGCAGACCGACATTAAACGCGTGCTGGCCTATTCCACCATGAGCCAGATTGGCTACATGTTCCTGGCG
CTCGGCGTACAGGCGTGGGATGCGGCAATTTTTCATCTGATGACCCATGCGTTCTTCAAAGCGCTGCTGTTCCTGGCGTC
CGGCTCGGTAATTCTGGCCTGCCATCACGAACAGAACATCTTTAAGATGGGCGGTCTGCGTAAGTCCATTCCGCTGGTGT
ATGCCTGCTTCCTGGTGGGGGGCGCGGCGCTGTCGGCGCTGCCGCTGGTCACTGCGGGCTTCTTCAGTAAGGATGAGATC
CTGGCCGGGGCGATGGCGAACGGTCATATCAATCTGATGGTGGCGGGTCTGGTCGGCGCGTTCATGACCTCCCTGTACAC
CTTCCGGATGATTTTCATCGTCTTCCACGGTAAAGAACAAATTCACGCTCATGCAGGGAAGGGGATTACCCACCATCTGC
CGCTGATTGTCCTGATGATTCTGTCTACCTTTGTTGGCGCGCTGATTGTGCCGCCATTGCAGGGGGTGCTGCCGCAGACA
ACTGAACTGGCGCATGGTCGCGTCATGACGCTGGAAATTACCTCTGGCGTAGTGGCGATTGCCGGCATCCTGATTGCCGC
ATGGCTGTGGCTGGGTAAACGCACGCTGGTGACGTCGATCGCCAACAGCGCGCCGGGCCGTCTGCTGGGGACCTGGTGGT
ATAACGCCTGGGGCTTTGACTGGCTGTACGACAAAGTATTCGTCAAGCCATTCCTCGGTATCGCCTGGCTGCTGAAGCGC
GACCCGCTTAATGCGTTGATGAACATTCCGGCTATCCTTTCCCGTTTTGCAGGCAAAGGCCTGGTACTGAGCGAGAACGG
TTATTTGCGCTGGTATGTGGCATCCATGAGCATCGGCGCGGTTGTGGTGCTGGCGCTGCTGATGGTACTGCGTTGA

Upstream 100 bases:

>100_bases
CGGCTGCGGAAGCGAGTATTGGACTTGCGCTGTTGCTGCAACTCCATCGCCGTCGCCAGAACCTGAACATCGATTCAGTA
AGTGAGATGCGTGGATGAAC

Downstream 100 bases:

>100_bases
TCGTAAAGTGAATTTTATCCAAATTCGTTGAAAATCAGGCCTCTGTCAGAGGCCTTAAAAAGGAATAAAAATCGCCATGT
TACTACCCTGGCTAATATTG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLVLD
GLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPK
NGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLADA
MAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMFLA
LGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEI
LAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLPQT
TELAHGRVMTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGRLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLLKR
DPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR

Sequences:

>Translated_611_residues
MLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLVLD
GLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPK
NGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLADA
MAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMFLA
LGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEI
LAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLPQT
TELAHGRVMTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGRLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLLKR
DPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR
>Mature_611_residues
MLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQPLWTWMSVGNFNIGFNLVLD
GLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPK
NGAAAMKAFVVTRVGDVFLAFALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLADA
MAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQTDIKRVLAYSTMSQIGYMFLA
LGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNIFKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEI
LAGAMANGHINLMVAGLVGAFMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLPQT
TELAHGRVMTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGRLLGTWWYNAWGFDWLYDKVFVKPFLGIAWLLKR
DPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGAVVVLALLMVLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=381, Percent_Identity=39.1076115485564, Blast_Score=252, Evalue=8e-67,
Organism=Escherichia coli, GI1788614, Length=599, Percent_Identity=94.6577629382304, Blast_Score=1152, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=415, Percent_Identity=34.2168674698795, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788827, Length=471, Percent_Identity=28.0254777070064, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788831, Length=362, Percent_Identity=28.7292817679558, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788613, Length=481, Percent_Identity=25.7796257796258, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI2367154, Length=289, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=399, Percent_Identity=24.812030075188, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66217; Mature: 66217

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQ
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHH
PLWTWMSVGNFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPKNGAAAMKAFVVTRVGDVFLA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
FALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLADA
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQT
HCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
FKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEILAGAMANGHINLMVAGLVGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHH
FMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLPQT
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TELAHGRVMTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGRLLGTWWYNAWGFD
HHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHCCCCHH
WLYDKVFVKPFLGIAWLLKRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHHHH
VVVLALLMVLR
HHHHHHHHHHC
>Mature Secondary Structure
MLALTIILPLIGFVLLAFSRGRWSENLSATIGVGSVGLAALVTAFVGMDFFANGKQAFSQ
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHH
PLWTWMSVGNFNIGFNLVLDGLSLTMLSVVTGVGFLIHMFASWYMRGEEGYSRFFAYTNL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FIASMVVLVLSDNLLLMYLGWEGVGLCSYLLIGFYYSDPKNGAAAMKAFVVTRVGDVFLA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
FALFILYNELGTLNFREMVELAPAHFADGNNMLMWATLMLLGGAVGKSAQLPLQTWLADA
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MAGPTPVSALIHAATMVTAGVYLIARTHGLFLMTPEILHLVGIIGAITLVMAGFAALVQT
HCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLASGSVILACHHEQNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
FKMGGLRKSIPLVYACFLVGGAALSALPLVTAGFFSKDEILAGAMANGHINLMVAGLVGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHH
FMTSLYTFRMIFIVFHGKEQIHAHAGKGITHHLPLIVLMILSTFVGALIVPPLQGVLPQT
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TELAHGRVMTLEITSGVVAIAGILIAAWLWLGKRTLVTSIANSAPGRLLGTWWYNAWGFD
HHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEHHHCCCCHH
WLYDKVFVKPFLGIAWLLKRDPLNALMNIPAILSRFAGKGLVLSENGYLRWYVASMSIGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEHHHHHH
VVVLALLMVLR
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]