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The map label for this gene is sirC [H]

Identifier: 194737340

GI number: 194737340

Start: 4450792

End: 4451667

Strand: Reverse

Name: sirC [H]

Synonym: SeSA_A4570

Alternate gene names: 194737340

Gene position: 4451667-4450792 (Counterclockwise)

Preceding gene: 194736043

Following gene: 194737413

Centisome position: 94.53

GC content: 35.39

Gene sequence:

>876_bases
ATGCTAAAAGTATTTAATCCCTCACCTGTCCAGGTGGGGAGCATTGAATGTTTACAATCAGCGCAAAACTGGCAGAGGAA
ATCCTTATCACTTCAGGGATTAAATTTACTGCAGTCCGTGCTCATCAAGCTCACCACGGGTAAAATTTCAATTACGACAT
CGTCCGGGGAGTATATTACGGCATCAGGGCCAATGTTAATATTTTTAGCTAAAGATCAAACCATTCATATAACAATGGAA
GAGACTCATGAACAGTTAAATTATAATTTAATTGAATTAGATTCAGCGTCAATAAAAAATGCTTATAATTTTTTTCTGTA
TGAACATGCAGACTTTTCGGCCCCATTAACAAAACCGACGACAAAACATCTGTTAGCGCCAATAGAAACAGGCGTAGCAA
GAGTATTCAACCTCTTACACTCTTCAAATAAAAGCCAAAAACTATCCCAAGATAAAAAGGAATATTTAATAAGATTTCTA
CTTTCAGAGTTCATCTATGAACCCGAAGCATTTGCTCTCTTCAGAGAACTATCGCAAAATACATTAGCCGAAAACATTTA
TAATATTATTATAAGCGACATAAGTCGAAAATGGGCGCTCAAGGATATTTCTGACTCACTCTATATGAGTTGTTCCACAT
TAAAGAGGAAATTGAAACAAGAGAACACCTCATTCAGCGAAGTTTACCTTAATGCGCGAATGAATAAAGCGACAAAACTT
CTACGCAATAGTGAATATAATATTACCCGAGTGGCTTATATGTGTGGTTATGATAGTGCTTCTTATTTTACATGCGTTTT
TAAAAAACACTTCAAAACTACACCATCGGAATTTTTAGCGTTTTTATCTTCCTCTCGTCATCAATATGTTAATTGA

Upstream 100 bases:

>100_bases
TTAAGTTCGCAAATAATTATATAGCTATATATTAGTTTTTTTGAAATATTTTTCAGAATAATTTTTGATTTACACGCACA
TTTAATAAAAGGAAATTATC

Downstream 100 bases:

>100_bases
GATATCTGACAATGCAGTATAAGAACAAAGCAAAACATATTAATATAAGAGATGGGATTCTGTTGCTCGCTAAAAAATTC
GACCTAACATTGAGCGAGAA

Product: AraC family regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN

Sequences:

>Translated_291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
>Mature_291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN

Specific function: Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789933, Length=245, Percent_Identity=30.2040816326531, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786776, Length=190, Percent_Identity=33.1578947368421, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790557, Length=166, Percent_Identity=33.7349397590361, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786778, Length=198, Percent_Identity=33.8383838383838, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787776, Length=95, Percent_Identity=45.2631578947368, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789932, Length=118, Percent_Identity=36.4406779661017, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786758, Length=101, Percent_Identity=32.6732673267327, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 33303; Mature: 33303

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYIT
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCEEEEEECCCCEEE
ASGPMLIFLAKDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPT
ECCCEEEEEECCCEEEEEEHHHHHHHCCCEEEECCHHHHHHHEEEEEECCCCCCCCCCCC
TKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYIT
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCEEEEEECCCCEEE
ASGPMLIFLAKDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPT
ECCCEEEEEECCCEEEEEEHHHHHHHCCCEEEECCHHHHHHHEEEEEECCCCCCCCCCCC
TKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]