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The map label for this gene is gnd [H]

Identifier: 194737009

GI number: 194737009

Start: 2178639

End: 2180045

Strand: Reverse

Name: gnd [H]

Synonym: SeSA_A2309

Alternate gene names: 194737009

Gene position: 2180045-2178639 (Counterclockwise)

Preceding gene: 194734817

Following gene: 194735251

Centisome position: 46.29

GC content: 51.88

Gene sequence:

>1407_bases
ATGTCCAAGCAACAGATCGGCGTCGTCGGTATGGCAGTGATGGGGCGCAACCTCGCGCTCAACATCGAAAGCCGTGGTTA
TACCGTCTCCGTTTTCAACCGCTCCCGTGAAAAGACCGAAGAAGTGATTGCCGAGAATCCCGGCAAAAAGCTGGTGCCTT
ATTATACGGTGAAAGAGTTTGTTGAATCCCTCGAAACGCCTCGTCGTATCCTGTTAATGGTGAAAGCGGGCGCAGGTACT
GATGCAGCTATCGATTCGCTGAAACCGTATCTGGAAAAAGGCGATATCATTATTGATGGCGGTAACACCTTCTTCCAGGA
CACAATCCGTCGCAATCGCGAGCTGTCTGCGGAAGGTTTTAACTTTATCGGTACCGGTGTTTCCGGTGGTGAAGAGGGCG
CGCTGAAAGGGCCATCTATCATGCCTGGCGGTCAGAAAGATGCCTATGAACTGGTGGCGCCGATCCTGACGAAGATTGCT
GCCGTGGCGGAAGATGGCGAACCGTGCGTGACCTATATCGGCGCCGATGGTGCTGGTCACTACGTCAAGATGGTCCATAA
TGGTATTGAATATGGCGATATGCAGCTTATCGCTGAAGCTTACTCCTTGCTGAAAGGCGGCCTGAACCTCAGCAATGAAG
AGTTGGCGAACACTTTTACTGAGTGGAATAACGGCGAGCTGAGCAGCTATCTGATCGACATCACTAAAGACATCTTCACT
AAAAAAGATGAAGACGGAAACTACCTGGTGGATGTCATTCTTGATGAAGCCGCCAACAAAGGGACCGGTAAATGGACCAG
CCAGAGCGCGCTGGATCTGGGTGAACCGCTGTCGCTGATTACCGAATCCGTCTTTGCGCGTTACATCTCTTCGTTGAAAG
CGCAACGTGTTGCCGCATCTAAAGTGCTCTCCGGGCCGAAAGCGCAGCCGGCAGGCGACAAAGCGGAATTTATCGAGAAA
GTGCGTCGCGCGCTGTATCTTGGCAAGATCGTCTCTTATGCGCAGGGCTTCTCGCAGCTACGCGCCGCGTCTGATGAATA
TCACTGGGATCTTAACTACGGCGAGATTGCTAAGATTTTCCGTGCGGGCTGTATCATTCGCGCTCAGTTCCTGCAGAAAA
TCACCGATGCTTACGCAGAAAACGCCGGTATTGCCAATTTGCTGTTAGCGCCTTACTTCAAGAAAATTGCTGATGAGTAC
CAGCAGGCGCTGCGTGATGTTGTGGCTTACGCGGTGCAGAACGGCATTCCGGTGCCGACATTCTCTGCGGCAGTGGCCTA
CTATGACAGCTATCGCGCCGCAGTACTGCCAGCTAACTTAATTCAGGCGCAGCGTGACTACTTTGGTGCGCACACCTATA
AACGTACTGATAAAGAAGGCATTTTCCATACCGAATGGTTGGAGTAA

Upstream 100 bases:

>100_bases
ATCGCTACCTTAATATCATATCTTTGAGTTAACATACTATTCACCTTTAACCTGCCATGACCGTTTGTGGCAGGGTTTCC
ACACCTGACAGGAGTATGTA

Downstream 100 bases:

>100_bases
TTTCTGCAAAAATGTTTAAGCCCGGTTTAATACCGGGCTTTTTTTTATCTCTATTCTTATTGATTTATCGCTTTTACTTA
ATATTAACTTAATAATCTGT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGT
DAAIDSLKPYLEKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELANTFTEWNNGELSSYLIDITKDIFT
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKAQRVAASKVLSGPKAQPAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASDEYHWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENAGIANLLLAPYFKKIADEY
QQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDKEGIFHTEWLE

Sequences:

>Translated_468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGT
DAAIDSLKPYLEKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIA
AVAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELANTFTEWNNGELSSYLIDITKDIFT
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKAQRVAASKVLSGPKAQPAGDKAEFIEK
VRRALYLGKIVSYAQGFSQLRAASDEYHWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENAGIANLLLAPYFKKIADEY
QQALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDKEGIFHTEWLE
>Mature_467_residues
SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTD
AAIDSLKPYLEKGDIIIDGGNTFFQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIAA
VAEDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELANTFTEWNNGELSSYLIDITKDIFTK
KDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKAQRVAASKVLSGPKAQPAGDKAEFIEKV
RRALYLGKIVSYAQGFSQLRAASDEYHWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENAGIANLLLAPYFKKIADEYQ
QALRDVVAYAVQNGIPVPTFSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDKEGIFHTEWLE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=53.091684434968, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=96.5811965811966, Blast_Score=929, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=50.3184713375796, Blast_Score=486, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=49.4553376906318, Blast_Score=458, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=50.2212389380531, Blast_Score=445, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=52.0169851380042, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51338; Mature: 51207

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVKEF
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDAAIDSLKPYLEKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELANTFTEWNNGELSSYLIDITKDIFT
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKAQRVAAS
CCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPKAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASDEYHWDLNYGEIAKIF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
RAGCIIRAQFLQKITDAYAENAGIANLLLAPYFKKIADEYQQALRDVVAYAVQNGIPVPT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDKEGIFHTEWLE
HHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAENPGKKLVPYYTVKEF
CCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VESLETPRRILLMVKAGAGTDAAIDSLKPYLEKGDIIIDGGNTFFQDTIRRNRELSAEGF
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKDAYELVAPILTKIAAVAEDGEPCVTYIGADGAGH
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
YVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELANTFTEWNNGELSSYLIDITKDIFT
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
KKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLITESVFARYISSLKAQRVAAS
CCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KVLSGPKAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQLRAASDEYHWDLNYGEIAKIF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
RAGCIIRAQFLQKITDAYAENAGIANLLLAPYFKKIADEYQQALRDVVAYAVQNGIPVPT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRTDKEGIFHTEWLE
HHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]