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The map label for this gene is msrA [H]

Identifier: 194736802

GI number: 194736802

Start: 4544147

End: 4544785

Strand: Reverse

Name: msrA [H]

Synonym: SeSA_A4676

Alternate gene names: 194736802

Gene position: 4544785-4544147 (Counterclockwise)

Preceding gene: 194735170

Following gene: 194736200

Centisome position: 96.51

GC content: 54.15

Gene sequence:

>639_bases
ATGAGTTTATTTGATAAAAAACATCTGGTTACTCAAGCAGATGCGTTACCAGGACGCAACACCCCGATGCCGATCGCCAC
TCTGCATGCGGTAAATGAACACTCTATGACCAATGTCCCTGCCGGGATGGAGATCGCCTACTTCGCTATGGGCTGTTTCT
GGGGCGTAGAACGTTTATTCTGGCAATTGCCCGGCGTATATAGCACCGCGGCAGGGTATGCGGGCGGTTACACGCCTAAT
CCAACCTACCGGGAAGTCTGCTCCGGGCAGACCGGTCATGCCGAAGCGGTACGGATAGTGTACGATCCTGCCGTTATCCG
TTATGAGCAGCTTTTACAGATTTTCTGGGAAAATCACGATCCAACGCAGGGGATGCAACAGGGTAACGATCACGGTACGC
AATACCGTTCTGCGATTTATCCCTTAACGCCGGAACAGAGTGCCGCTGCTCACGCCAGTCGCGAGCGCTTTCAGTCGGCA
ATGGCCGCCGCCGGAAACCATCGCCCTATTACCACGGAAATCACCCATGCGACGCCGTTTTACTACGCCGAAGATGAACA
CCAACAGTATCTGCACAAAAATCCATACGGTTACTGTGGGATTGGCGGGATCGGCGTTTGCCTGCCGCCTGACGCGTGA

Upstream 100 bases:

>100_bases
TTCTTATGGTTAAATCCAGATACATTAATGTTGTTATTGTGTGCAAAGATGCGTCTCGTTACAACCTTAACGCCAATTAA
CGCTTTCGGGAGAATAGCTC

Downstream 100 bases:

>100_bases
CGACGCTGGCGTAGGGGGAACTTGTCGGAGTTGAAAATGAACCCTCTGGCGACTTTACAGTAGCTTACGCTATACTAGCC
CTGAACTTATCGGCTCACTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPN
PTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQIFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQSAAAHASRERFQSA
MAAAGNHRPITTEITHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA

Sequences:

>Translated_212_residues
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPN
PTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQIFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQSAAAHASRERFQSA
MAAAGNHRPITTEITHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
>Mature_211_residues
SLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPNP
TYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQIFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQSAAAHASRERFQSAM
AAAGNHRPITTEITHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=203, Percent_Identity=58.6206896551724, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=60.2209944751381, Blast_Score=236, Evalue=9e-63,
Organism=Homo sapiens, GI208609993, Length=203, Percent_Identity=43.8423645320197, Blast_Score=166, Evalue=1e-41,
Organism=Escherichia coli, GI1790665, Length=212, Percent_Identity=87.7358490566038, Blast_Score=369, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=38, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=35.3293413173653, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=38.8235294117647, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=41.2587412587413, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=37.6470588235294, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23450; Mature: 23319

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLF
CCCCCCHHHHHHHHCCCCCCCCCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQIFWENHD
HHCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCC
PTQGMQQGNDHGTQYRSAIYPLTPEQSAAAHASRERFQSAMAAAGNHRPITTEITHATPF
CHHHHHCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
YYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
EEECHHHHHHHHCCCCCEECCCCCEEECCCCC
>Mature Secondary Structure 
SLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLF
CCCCCHHHHHHHHCCCCCCCCCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
WQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQIFWENHD
HHCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCC
PTQGMQQGNDHGTQYRSAIYPLTPEQSAAAHASRERFQSAMAAAGNHRPITTEITHATPF
CHHHHHCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
YYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
EEECHHHHHHHHCCCCCEECCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA