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The map label for this gene is sixA [H]

Identifier: 194736282

GI number: 194736282

Start: 2500118

End: 2500603

Strand: Reverse

Name: sixA [H]

Synonym: SeSA_A2616

Alternate gene names: 194736282

Gene position: 2500603-2500118 (Counterclockwise)

Preceding gene: 194735469

Following gene: 194736067

Centisome position: 53.1

GC content: 55.14

Gene sequence:

>486_bases
ATGCAAGTTTTTATCATGCGTCACGGCGACGCAGCCCTCGATGCCGCCAGTGATTCGGTTCGTCCCTTGACCCCTTGTGG
GTGTGACGAGTCTCGCCTGATGGCGAACTGGCTGAAAGGTCAAAAAGTGGATATCGAACGTGTTCTGGTGAGTCCGTTTC
TTCGGGCCGAACAGACGTTAGATGTGGTCGGCGATTGTATGAATCTGCCGGCTCAGGTGGATGTCCTGCCGGAGCTAACG
CCCTGTGGCGATGTCGGTCTGGTCAGCGCCTACCTCCAGGCGCTGGCCAATGAAGAGATCGGATCGGTGCTGGTGATCTC
TCACTTACCTCTGGTCGGATACCTGGTATCTGAGCTTTGTCCGGGCGAAACGCCGCCGATGTTCACGACGTCCGCAATTG
CCAACGTTACGCTTGATGAAAGCGGCAAGGGGACATTCAACTGGCAAATGAGTCCCTGCAATCTGAAAATGGCGAAAGCG
ATTTAA

Upstream 100 bases:

>100_bases
GAATGGATAAGGCACAATGCCGGCCACCGCATTTTTGCCGCAGCCAATAGGGGCATGTGGTAAGCGTGTTGGTGAAACTG
GTTAACAAAAGCGGTGCAAT

Downstream 100 bases:

>100_bases
TCTTTGCTGCCTGATGGCGCTTCGCTTATCAGGCCTACGACAGCGTTGGCTGTTCGTAGGCTGGATAAGGCGCTTGCGCC
GCCATCCGGCAATTCCGCAT

Product: phosphohistidine phosphatase

Products: NA

Alternate protein names: RX6 [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MQVFIMRHGDAALDAASDSVRPLTPCGCDESRLMANWLKGQKVDIERVLVSPFLRAEQTLDVVGDCMNLPAQVDVLPELT
PCGDVGLVSAYLQALANEEIGSVLVISHLPLVGYLVSELCPGETPPMFTTSAIANVTLDESGKGTFNWQMSPCNLKMAKA
I

Sequences:

>Translated_161_residues
MQVFIMRHGDAALDAASDSVRPLTPCGCDESRLMANWLKGQKVDIERVLVSPFLRAEQTLDVVGDCMNLPAQVDVLPELT
PCGDVGLVSAYLQALANEEIGSVLVISHLPLVGYLVSELCPGETPPMFTTSAIANVTLDESGKGTFNWQMSPCNLKMAKA
I
>Mature_161_residues
MQVFIMRHGDAALDAASDSVRPLTPCGCDESRLMANWLKGQKVDIERVLVSPFLRAEQTLDVVGDCMNLPAQVDVLPELT
PCGDVGLVSAYLQALANEEIGSVLVISHLPLVGYLVSELCPGETPPMFTTSAIANVTLDESGKGTFNWQMSPCNLKMAKA
I

Specific function: Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His- Asp phosphorelay [H]

COG id: COG2062

COG function: function code T; Phosphohistidine phosphatase SixA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sixA phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788681, Length=161, Percent_Identity=89.4409937888199, Blast_Score=300, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR004449 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: 3.1.3.- [C]

Molecular weight: Translated: 17291; Mature: 17291

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVFIMRHGDAALDAASDSVRPLTPCGCDESRLMANWLKGQKVDIERVLVSPFLRAEQTL
CEEEEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DVVGDCMNLPAQVDVLPELTPCGDVGLVSAYLQALANEEIGSVLVISHLPLVGYLVSELC
HHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHCCHHHHHHHHHC
PGETPPMFTTSAIANVTLDESGKGTFNWQMSPCNLKMAKAI
CCCCCCCEEHHHHEEEEECCCCCCEEEEEECCCCEECCCCC
>Mature Secondary Structure
MQVFIMRHGDAALDAASDSVRPLTPCGCDESRLMANWLKGQKVDIERVLVSPFLRAEQTL
CEEEEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DVVGDCMNLPAQVDVLPELTPCGDVGLVSAYLQALANEEIGSVLVISHLPLVGYLVSELC
HHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHHCCHHHHHHHHHC
PGETPPMFTTSAIANVTLDESGKGTFNWQMSPCNLKMAKAI
CCCCCCCEEHHHHEEEEECCCCCCEEEEEECCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9489669; 9205837; 9278503 [H]