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The map label for this gene is serS [H]

Identifier: 194735850

GI number: 194735850

Start: 1052302

End: 1053594

Strand: Direct

Name: serS [H]

Synonym: SeSA_A1077

Alternate gene names: 194735850

Gene position: 1052302-1053594 (Clockwise)

Preceding gene: 194734760

Following gene: 194738277

Centisome position: 22.35

GC content: 53.67

Gene sequence:

>1293_bases
ATGCTCGATCCCAATCTGCTGCGTAATGAGCCAGACGCAGTCGCTGAAAAACTGGCACGCCGGGGCTTTAAGCTGGATGT
AGATAAGCTGCGCGCTCTTGAAGAGCGTCGTAAAGTTTTGCAGGTCAACACGGAAAACCTGCAGGCGGAGCGTAATTCTC
GATCGAAATCCATCGGCCAGGCGAAAGCGCGCGGGGAAGATATCGAGCCTTTACGCCTGGAAGTGAATAAACTGGGCGAA
GAGCTGGATGCGGCGAAAGCCGAGCTGGATACCTTGCTGGCGGAGATCCGCAATATCGCGCTGACCATCCCAAACCTGCC
TGCGGATGAAGTGCCGGTAGGTAAAGATGAAAACGACAACGTTGAAGTCAGCCGCTGGGGTACCCCGCGTGAGTTTGATT
TTGAAATCCGCGATCACGTCACCTTAGGGGAAATGCACTCCGGCCTCGACTTTGCCGCCGCGGTTAAGCTGACCGGCTCC
CGTTTTGTAGTGATGAAAGGACAGATTGCGCGTATGCATCGCGCATTGTCGCAGTTCATGTTGGATCTGCATACGGAACA
GCACGGCTATAGCGAAAACTACGTGCCGTATCTGGTTAACCACGACACGCTGTATGGCACCGGTCAACTGCCGAAATTCG
CAGGCGATTTGTTCCATACCCGTCCGCTGGAAGAAGAAGCAGACAGCAGCAACTATGCTTTGATCCCGACGGCGGAGGTT
CCGCTGACCAATCTGGTACGCGATGAAATCATCGACGAAGATCAGCTGCCAATTAAAATGACGGCGCATACGCCTTGTTT
CCGTTCTGAAGCAGGTTCTTATGGTCGTGATACCCGTGGCCTGATTCGTATGCATCAGTTTGACAAAGTGGAAATGGTGC
AGATCGTTCGCCCGGAAGATTCTATGGCTGCGTTGGAAGAGATGACCGGTCACGCGGAAAAAGTGCTCCAGCTACTGGGA
CTGCCGTACCGTAAAATTATTCTGTGCACTGGTGATATGGGCTTCGGCGCCTGCAAAACCTATGACCTCGAAGTCTGGGT
TCCGGCGCAGAATACCTACCGCGAGATCTCTTCCTGCTCTAACGTCTGGGACTTCCAGGCGCGTCGTATGCAGGCACGCT
GTCGCAGCAAGTCCGACAAAAAGACCCGTCTGGTCCATACCCTGAATGGTTCTGGTCTGGCGGTAGGTCGTACCCTGGTG
GCCGTGATGGAAAACTATCAGCAGGCTGATGGTCGCATTGAAGTGCCGGAAGTATTACGTCCGTACATGAACGAACTGGA
ATATATCGGCTAA

Upstream 100 bases:

>100_bases
GTCGCTATTACGTAAACGTGGTTTACGTTCATCAATACAATCAGAGGCGATCATCAATTGATCGCGTTTCCTTTTATTAT
TCGATAAGCACAGGATAAGC

Downstream 100 bases:

>100_bases
TCCTCGCTTTCTCTTCTTCTAAAAAGCGCCTTCGGGCGCTTTTTTTATGCCAGTTTGATACCGGACAATAATCCCTACCC
TATTAGGGGTAATACTGATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDTLLAEIRNIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNELEYIG

Sequences:

>Translated_430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDTLLAEIRNIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNELEYIG
>Mature_430_residues
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGE
ELDAAKAELDTLLAEIRNIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGS
RFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
PLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLG
LPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLV
AVMENYQQADGRIEVPEVLRPYMNELEYIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=375, Percent_Identity=35.2, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI8923421, Length=344, Percent_Identity=30.2325581395349, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI225579074, Length=344, Percent_Identity=30.2325581395349, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=97.2093023255814, Blast_Score=868, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=437, Percent_Identity=31.1212814645309, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=335, Percent_Identity=30.7462686567164, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321799, Length=414, Percent_Identity=30.1932367149758, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320226, Length=395, Percent_Identity=30.6329113924051, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24581334, Length=469, Percent_Identity=31.7697228144989, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17737985, Length=272, Percent_Identity=35.6617647058824, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48652; Mature: 48652

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEELDAAKAELDTLLAEIRNIALTIPNLPADEVPVGKDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
VEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCHHHCCEEHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
HHHHHHCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCCCCCHHCCCCCEEEEECCCC
PLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMNELEYIG
HHHHHHHCCC
>Mature Secondary Structure
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQ
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHH
AKARGEDIEPLRLEVNKLGEELDAAKAELDTLLAEIRNIALTIPNLPADEVPVGKDENDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
VEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCHHHCCEEHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEV
HHHHHHCCCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCCCCCHHCCCCCEEEEECCCC
PLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
CHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCH
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCS
HHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHH
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHH
PYMNELEYIG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA