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The map label for this gene is nupC [H]

Identifier: 194735794

GI number: 194735794

Start: 2527984

End: 2529186

Strand: Direct

Name: nupC [H]

Synonym: SeSA_A2643

Alternate gene names: 194735794

Gene position: 2527984-2529186 (Clockwise)

Preceding gene: 194736081

Following gene: 194737057

Centisome position: 53.68

GC content: 51.12

Gene sequence:

>1203_bases
ATGGACCGCGTCCTTCATTTTGTCCTGGCGCTTGCCGTTGTTGCGGTACTCGCACTGCTGGTTAGCAGTGACCGTAAAAA
AATTCGCATTCGTTATGTCATTCAGTTACTTGTTATCGAAGTGCTACTGGCCTGGTTCTTCCTGAACTCTGATGTTGGCC
TTGGCTTCGTAAAAGGTTTCTCCGAGATGTTTGAAAAACTGCTCGGATTTGCCAACGAAGGGACAAACTTCGTCTTCGGC
AGTATGAACGATCAAGGTTTGGCGTTCTTCTTCCTGAAAGTATTGTGCCCGATTGTCTTTATTTCCGCGTTGATCGGTAT
TCTCCAGCATATCCGTGTTCTGCCAGTGGTCATCCGCGCTATTGGTTTCCTGCTGTCCAAAGTAAACGGTATGGGCAAAC
TGGAATCTTTTAACGCCGTCAGCTCGCTGATCCTCGGCCAGTCTGAGAACTTTATCGCTTATAAAGATATCCTCGGCAAA
ATGTCCCGTAACCGCATGTACACCATGGCTGCAACGGCGATGTCGACCGTTTCCATGTCTATTGTGGGCGCGTATATGAC
CATGCTGGACCCTAAATATGTGGTCGCAGCGCTGGTTCTGAACATGTTCAGCACCTTTATCGTACTGTCGCTGATCAACC
CCTATACCGTTGATGCCAGCGAAGAAAATATTCAGATGTCGAACCTGCATGAAGGCCAAAGTTTCTTCGAAATGCTGGGC
GAGTACATTCTGGCAGGTTTTAAAGTGGCGATTATCGTCGCGGCGATGCTGATCGGCTTCATCGCGCTGATCGCGGCCCT
GAACGCCCTGTTCGCCACCGTGACCGGCTGGTTTGGTTACAGCATCTCCTTCCAGGGCATCCTGGGCTACATCTTCTACC
CGGTTGCATGGGTAATGGGTGTGCCGTCCAGCGAAGCGCTGCAGGTGGGCAGTATCATGGCGACCAAACTGGTTTCCAAC
GAATTCGTGGCGATGATGGATCTGCAGAAAATTGCCGCCACTCTCTCTCCGCGTGCAGAAGGTATCCTGTCCGTCTTCCT
GGTATCCTTCGCGAACTTCTCTTCCATCGGTATTATTGCGGGCGCGATTAAAGGCCTGAACGAAGAGCAAGGCAACGTGG
TTTCCCGTTTTGGTCTGAAACTGGTTTACGGTTCTACGCTGGTGAGCGTACTGTCCGCCTCTATCGCGGCGCTGGTACTG
TAA

Upstream 100 bases:

>100_bases
TCACAGGTCCTTATTATAGTGTGTGTTGGATCTCGTTTTCTTTACGGCTGTTGCATAGAATGTGCACGAAAATTAAACCT
GCCTCATATTTGGAGCAAAT

Downstream 100 bases:

>100_bases
GTCTGCGTTTAATGTAAAAACCGGGGAGCTATCCCCGGTTTTTTTTATGCCGCTTATTTGCCTAACGGGCGCGGGCGGCC
AATCAGATATCCCTGCAAAC

Product: nucleoside transporter NupC

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDRVLHFVLALAVVAVLALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFG
SMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVVIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGK
MSRNRMYTMAATAMSTVSMSIVGAYMTMLDPKYVVAALVLNMFSTFIVLSLINPYTVDASEENIQMSNLHEGQSFFEMLG
EYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPSSEALQVGSIMATKLVSN
EFVAMMDLQKIAATLSPRAEGILSVFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL

Sequences:

>Translated_400_residues
MDRVLHFVLALAVVAVLALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFG
SMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVVIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGK
MSRNRMYTMAATAMSTVSMSIVGAYMTMLDPKYVVAALVLNMFSTFIVLSLINPYTVDASEENIQMSNLHEGQSFFEMLG
EYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPSSEALQVGSIMATKLVSN
EFVAMMDLQKIAATLSPRAEGILSVFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL
>Mature_400_residues
MDRVLHFVLALAVVAVLALLVSSDRKKIRIRYVIQLLVIEVLLAWFFLNSDVGLGFVKGFSEMFEKLLGFANEGTNFVFG
SMNDQGLAFFFLKVLCPIVFISALIGILQHIRVLPVVIRAIGFLLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGK
MSRNRMYTMAATAMSTVSMSIVGAYMTMLDPKYVVAALVLNMFSTFIVLSLINPYTVDASEENIQMSNLHEGQSFFEMLG
EYILAGFKVAIIVAAMLIGFIALIAALNALFATVTGWFGYSISFQGILGYIFYPVAWVMGVPSSEALQVGSIMATKLVSN
EFVAMMDLQKIAATLSPRAEGILSVFLVSFANFSSIGIIAGAIKGLNEEQGNVVSRFGLKLVYGSTLVSVLSASIAALVL

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=394, Percent_Identity=26.3959390862944, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI11545853, Length=406, Percent_Identity=24.1379310344828, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI227116277, Length=403, Percent_Identity=22.8287841191067, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1788737, Length=400, Percent_Identity=97.75, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI1788485, Length=413, Percent_Identity=31.7191283292978, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788488, Length=413, Percent_Identity=30.7506053268765, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560276, Length=394, Percent_Identity=25.1269035532995, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71991794, Length=392, Percent_Identity=25.5102040816327, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45552517, Length=391, Percent_Identity=25.8312020460358, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552519, Length=391, Percent_Identity=25.8312020460358, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921868, Length=391, Percent_Identity=25.8312020460358, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281360430, Length=344, Percent_Identity=24.1279069767442, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43381; Mature: 43381

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]