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The map label for this gene is mtlD [H]

Identifier: 194735630

GI number: 194735630

Start: 3756878

End: 3758026

Strand: Direct

Name: mtlD [H]

Synonym: SeSA_A3886

Alternate gene names: 194735630

Gene position: 3756878-3758026 (Clockwise)

Preceding gene: 194737376

Following gene: 194735117

Centisome position: 79.78

GC content: 54.13

Gene sequence:

>1149_bases
ATGAAAGCATTACATTTTGGCGCAGGTAATATCGGTCGTGGCTTTATCGGCAAACTGCTGGCTGACGCGGGGATACAACT
GACGTTTGCGGATGTAAACCAGGTCGTACTCGATGCCCTGAATGCCCGTCATAGCTATCAGGTTCATGTTGTGGGTGAAA
ATGAGCAGGTGGATACCGTTTCCGGCGTCAACGCTGTCAGCAGCATCGGCGATGATGTTGTCGACCTGATTGCCCACGTT
GATTTAATCACTACTGCCGTGGGTCCGGTTGTGCTTGAGCGTATCGCTCCGGCCATCGCTAAAGGGCTGGTAAAACGTAA
GGCGCAGGGCGTGGATGCCCCGCTGAATATCATCGCCTGTGAAAATATGGTGCGCGGCACCACACAGCTCAAAGGTCATG
TGATGAACGCGCTGGCGGATGGCGATAAAGCCTGGGTTGAACAGCACGTCGGTTTTGTCGATTCCGCCGTTGACCGTATT
GTGCCGCCATCTGCTTCCGCCACCCATGACCCGCTGGAAGTGACGGTAGAAACCTTCAGCGAGTGGATCGTCGATAAAAC
CCAGTTTAAAGGCGCGTTGCCGACCATTCCGGGGATGGAGTTAACGGATAACCTGATGGCATTTGTCGAACGTAAACTCT
TCACGCTGAACACAGGTCATGCTATAACCGCGTACCTCGGCAAATTAGCCGGTCATCAAACCATTCGCGACGCCATTCTC
GATGAGAGTATTCGCGCGGTGGTTAAAGGCGCGATGGAAGAAAGCGGCGCGGTGCTGATCAAACGCTACGGTTTTGACGC
CGACAAACATGCGGCATACATTCAGAAAATCCTCGGTCGTTTTGAAAACCCGTATCTGAAAGATGATGTTGAGCGCGTTG
GACGTCAGCCGCTACGCAAACTCAGCGCGGGCGACCGTCTGATCAAACCGCTGCTTGGCACCCTGGAATATGGTCTGCCG
CATGTGAATCTGGTCAAAGGGATCGCGGCGGCGATGCATTTCCGTAGTGAAGAAGATCCGCAGGCACAGGAACTGGCCGC
GCTGATTGACGAAAAAGGTCCACAGGCCGCTCTGGCGCAAATTTCCGGGCTGGATGCCAATAGCGATGTGGTGGCGGAGG
CGGTTAACGCTTATAACGCGACCAAATGA

Upstream 100 bases:

>100_bases
AATATGAAGGCGATATCCTCTCCCTTGTGGAGAGGGTTAGGTTGAGGGAAAAGCCTCACCCCAGCCCTCTCGGGTAAAAA
CATTAATGAAGGTTAATACT

Downstream 100 bases:

>100_bases
CGCAGAACCCGGCGCAGGTTAGCCTGCGCCCAAATAACAGATTGTCAGATATGCAGGCAATAATGGAACAAACCCAGGCC
TTTGAAAATCGTGTGCTTGA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDDVVDLIAHV
DLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIACENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRI
VPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HVNLVKGIAAAMHFRSEEDPQAQELAALIDEKGPQAALAQISGLDANSDVVAEAVNAYNATK

Sequences:

>Translated_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDDVVDLIAHV
DLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIACENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRI
VPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HVNLVKGIAAAMHFRSEEDPQAQELAALIDEKGPQAALAQISGLDANSDVVAEAVNAYNATK
>Mature_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDDVVDLIAHV
DLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIACENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRI
VPPSASATHDPLEVTVETFSEWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HVNLVKGIAAAMHFRSEEDPQAQELAALIDEKGPQAALAQISGLDANSDVVAEAVNAYNATK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=92.6701570680628, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=267, Percent_Identity=28.4644194756554, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788497, Length=231, Percent_Identity=26.8398268398268, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790779, Length=259, Percent_Identity=27.7992277992278, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324401, Length=235, Percent_Identity=28.5106382978723, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=235, Percent_Identity=28.5106382978723, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 40938; Mature: 40938

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
SGVNAVSSIGDDVVDLIAHVDLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRIVPPSASATHDPLEVTVETFS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
EWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHVNLVKGIAAAMHFRSEEDPQAQELAALIDEKGPQAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHH
ISGLDANSDVVAEAVNAYNATK
HHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
SGVNAVSSIGDDVVDLIAHVDLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRIVPPSASATHDPLEVTVETFS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
EWIVDKTQFKGALPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHVNLVKGIAAAMHFRSEEDPQAQELAALIDEKGPQAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHH
ISGLDANSDVVAEAVNAYNATK
HHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA