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The map label for this gene is manA [H]

Identifier: 194735502

GI number: 194735502

Start: 1508263

End: 1509438

Strand: Reverse

Name: manA [H]

Synonym: SeSA_A1566

Alternate gene names: 194735502

Gene position: 1509438-1508263 (Counterclockwise)

Preceding gene: 194734192

Following gene: 194737139

Centisome position: 32.05

GC content: 54.17

Gene sequence:

>1176_bases
ATGCAAAAACTCATTAACTCAGTGCAAAACTATGCCTGGGGAAGTAAAACTGCGTTAACGGAACTTTATGGCATCGCCAA
TCCGCAGCAGCAGCCAATGGCTGAACTCTGGATGGGCGCGCATCCCAAAAGCAGCTCGCGAATCACCACCGCCAACGGCG
AAACCGTCTCCCTGCGTGACGCCATCGAAAAGAATAAAACCGCCATGCTGGGCGAAGCGGTAGCCAACCGTTTCGGCGAA
CTGCCGTTTCTGTTTAAAGTACTGTGCGCCGCGCAGCCGCTCTCTATTCAGGTACACCCGAATAAACGCAACTCCGAAAT
CGGTTTCGCGAAAGAAAATGCGGCGGGTATCCCCATGGATGCCGCAGAGCGGAACTATAAAGATCCTAACCATAAACCAG
AGCTGGTTTTTGCCCTGACGCCTTTTCTGGCGATGAACGCGTTCCGCGAATTTTCTGACATTGTCTCTTTACTGCAACCT
GTCGCCGGCGCGCATTCCGCTATCGCCCACTTTTTGCAGGCGCCAAACGCTGAACGTCTGAGCCAGCTTTTCGCCAGCCT
GTTGAATATGCAAGGCGAAGAAAAATCCCGCGCGTTAGCCGTACTCAAAGCGGCGCTTAACAGCCAGCAAGGCGAACCGT
GGCAAACGATCCGCGTGATTTCAGAGTATTATCCTGACGACAGCGGGCTTTTCTCTCCTTTGTTGCTGAATGTGATCAAA
CTGAATCCCGGCGAAGCGATGTTCCTGTTTGCCGAAACGCCTCACGCTTATCTGCAGGGCGTTGCGCTGGAAGTCATGGC
GAACTCCGATAACGTTCTGCGCGCTGGCCTTACGCCAAAATATATCGACATCCCTGAGCTGGTCGCGAACGTGAAGTTCG
AACCTAAGCCTGCCAGCGAGTTGCTGACTGCCCCGGTAAAAAGCGGCGCGGAGCTGGACTTCCCAATTCCGGTTGACGAT
TTTGCTTTTTCACTGCACGACCTGGCGCTTCAGGAGACGAGCATCGGCCAACACAGCGCCGCGATTCTGTTCTGCGTTGA
GGGTGAGGCGGTGTTACGTAAAGATGAACAGCGTCTGGTACTGAAGCCGGGTGAATCTGCCTTTATCGGCGCGGATGAGT
CTCCGGTTAACGCCAGCGGCACAGGCCGTTTAGCGCGTGTTTATAACAAGCTGTAG

Upstream 100 bases:

>100_bases
AACTGAGACAAGTACGACTTTTTACGCCCGGAGGTTACTTCATGCGGGTTTCTTGGTTTAATACCTCCCATTGATCTCCA
CATTGAAACAGGGCTTGATA

Downstream 100 bases:

>100_bases
CAACGTACTGAATTTTTTAACAACTCTTGCTAAGCTTATAACAGACGTAAAACTCCTCCAGGCGGTTTAATCCGCCTGGT
TTCATTTTTATGGACAATTG

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRDAIEKNKTAMLGEAVANRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQP
VAGAHSAIAHFLQAPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVIK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPASELLTAPVKSGAELDFPIPVDD
FAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL

Sequences:

>Translated_391_residues
MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRDAIEKNKTAMLGEAVANRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQP
VAGAHSAIAHFLQAPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVIK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPASELLTAPVKSGAELDFPIPVDD
FAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL
>Mature_391_residues
MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRDAIEKNKTAMLGEAVANRFGE
LPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQP
VAGAHSAIAHFLQAPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVIK
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPASELLTAPVKSGAELDFPIPVDD
FAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=407, Percent_Identity=34.8894348894349, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1787899, Length=391, Percent_Identity=86.1892583120205, Blast_Score=698, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997620, Length=403, Percent_Identity=32.0099255583127, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17557650, Length=403, Percent_Identity=27.0471464019851, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320839, Length=412, Percent_Identity=32.5242718446602, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI21356061, Length=403, Percent_Identity=31.7617866004963, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42607; Mature: 42607

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRD
CHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEHHH
AIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMD
HHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQPVAGAHSAIAHFLQAPNAERL
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
SQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVIK
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPASE
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCCCCHHHHHHCCCCCCCCHHH
LLTAPVKSGAELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCEEE
LKPGESAFIGADESPVNASGTGRLARVYNKL
ECCCCCEEECCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRITTANGETVSLRD
CHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEHHH
AIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRNSEIGFAKENAAGIPMD
HHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
AAERNYKDPNHKPELVFALTPFLAMNAFREFSDIVSLLQPVAGAHSAIAHFLQAPNAERL
HHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
SQLFASLLNMQGEEKSRALAVLKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVIK
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNPGEAMFLFAETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPASE
ECCCCEEEEEECCCHHHHCCEEEEEEECCCCEEEECCCCCCCCHHHHHHCCCCCCCCHHH
LLTAPVKSGAELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCEEE
LKPGESAFIGADESPVNASGTGRLARVYNKL
ECCCCCEEECCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]