| Definition | Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633 chromosome, complete genome. |
|---|---|
| Accession | NC_011094 |
| Length | 4,709,075 |
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The map label for this gene is sipA [H]
Identifier: 194735289
GI number: 194735289
Start: 2931884
End: 2933896
Strand: Reverse
Name: sipA [H]
Synonym: SeSA_A3035
Alternate gene names: 194735289
Gene position: 2933896-2931884 (Counterclockwise)
Preceding gene: 194735353
Following gene: 194734980
Centisome position: 62.3
GC content: 47.89
Gene sequence:
>2013_bases ATGCAGACCGAGATCAAAACGCAGGCCACGAATCTTGCGGCGAATCTTTCCGCAGTCAGAGAAAGTGCCACAGCGACGCT GTCAGGGGAAATTAAAGGCCCGCAACTGGAAGATTTTCCCGCGCTGATCAAACAGGCGAGTCTGGATGCGTTGTTTAAAT GCGGGAAAGACGCTGAGGCGTTAAAAGAAATTTTCACCAATTCAAATAATGTCGCCGGTAAGAAAGCGATAATGGAATTT GCCGGGCTCTTTCGTTCAGCGCTCAACGCCACCAGTGATTCTCCTGAGGCGAAGACGCTACTGATGAAGGTGGGGGCAGA GTATACCACGCAAATCATAAAAGATGGCCTGAAAGAAAAGTCAGCTTTTGGGCCATGGCTGCCAGAAACAAAGAAAGCGG AAGCGAAGCTGGAAAACCTGGAAAAGCAGCTGTTAGATATTATCAAAAATAACACTGGCGGTGAATTAAGTAAATTATCG ACGAATCTTGTTATGCAGGAGGTGATGCCCTATATTGCCAGCTGCATTGAACATAACTTTGGCTGTACGTTAGATCCGTT AACCCGTAGCAATCTTACGCAGCTTGTTGACGCCGCGGCGGCGAAGGCGGTTAAGGCGCTTGATATGTGCCACCAAAAAT TAACGCAAGAGCAGGGTACCAGCGTAGGACGGGAAGCCCGGCACCTTGAAATGCAAACGTTGATACCCCTGCTACTACGT AATGTTTTTGCACAAATTCCTGCAGATAAACTGCCTGACCCTAAAATTCCGGAACCTGCGGCTGGACCAGTACCTGATGG TGGGAAAAAAGCAGAACCTACGGGTATTAATATCAATATTAATATTGATAGCAGTAACCATAGCGTGGATAACAGTAAGC ATATTAACAATAGCCGAAGCCATGTCGATAATAGCCAGCGCCATATCGATAATAGCAACCATGATCATAGCCGGAAGACG ATTGATAATAGCCGAACATTTATTGATAACAGCCAACGCCATGGCGAGTCACACCATTCGACTAACAGCAGCAACGTAAG TCATAGTCATTCGCGTGTGGATTCGACTACGCATCAAACGGAGACGGCACACAGCGCCAGCACAGGGGCAATTGACCATG GCATCGCAGGTAAAATTGACATTACGGCTCATGCGACGGCAGAGGCTGTGACCAACGCTTCTTCCGAAAGTAAAGATGGA AAGGTGGTCACGTCAGAAAAGGGCACTACGGGTGAAACAACCTCTTTTGATGAAGTCGATGGCGTAACCAGCAAGAGCAT TATCGGCAAGCCGGTACAGGCCACGGTGCACGGCGTTGATGATAATAAACAGCAAAGCCAGACGGCAGAGATTGTGAATG TGAAGCCGCTTGCCAGTCAACTGGCTGGCGTCGAGAATGTTAAAATCGATACCTTACAATCAGACTCGACGGTAATTACA GGTAATAAAGCCGGTACGACCGATAATGATAATAGCCAGACAGATAAGACTGGCCCATTTTCTGGTTTGAAGTTTAAGCA AAATAGTTTCCTCTCAACAGTACCGAGCGTTACGAATATGCATTCAATGCATTTCAACGCCCGTGAGGCGTTTTTGGGTG TGATACGTAAAGCCCTGGAGCCGGATACCTCGACACCGTTCCCTGTACGCAGAGCGTTTGACGGCTTGCGTGCGGAAATA TTACCCAATGACACGATAAAGAGTGCAGCGTTGAAAGCGCAATGTAGCGATATTGACAAGCACCCAGCATTGAAAGCGAA AATGGAGACGCTCAAAGAGGTCATTACTCATCATCCACAAAAAGAAAAACTGGCTGAGATTGCATTGCAGTTTGCCAGAG AGGCGGGGTTGACCAGGCAAAAAGGGGAAACTGACTATGTGTTAAGTAATGTGCTGGACGGCCTTATCGGAGACGGTAGC TGGCGAGCTGGCCCGGCTTACGAGTCATACCTGAATAAACCTGGCGTGGATCGGGTTATTACTACCGTTGATGGCTTGCA CATGCAGCGTTAA
Upstream 100 bases:
>100_bases CAGCCTGGAAACCGCCAAAAGCTTCCTGCAAGGATAACAGAAGAGGATATTAATAATGGTTACAAGTGTAAGAACTCAGC CCCCCGTCATAATGCCAGGT
Downstream 100 bases:
>100_bases TTAACCGGGAAAGATGCGATGAATATGGATATTGAAGCAAGAGTCAAAAAAGTTATCACCTCCTGTATTGCCGTTGATGT TGATAGTATCAATGGTCAGA
Product: cell invasion protein SipA
Products: NA
Alternate protein names: Effector protein sipA [H]
Number of amino acids: Translated: 670; Mature: 670
Protein sequence:
>670_residues MQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEIFTNSNNVAGKKAIMEF AGLFRSALNATSDSPEAKTLLMKVGAEYTTQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLS TNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTQLVDAAAAKAVKALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLR NVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDHSRKT IDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDITAHATAEAVTNASSESKDG KVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKIDTLQSDSTVIT GNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFNAREAFLGVIRKALEPDTSTPFPVRRAFDGLRAEI LPNDTIKSAALKAQCSDIDKHPALKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGS WRAGPAYESYLNKPGVDRVITTVDGLHMQR
Sequences:
>Translated_670_residues MQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEIFTNSNNVAGKKAIMEF AGLFRSALNATSDSPEAKTLLMKVGAEYTTQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLS TNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTQLVDAAAAKAVKALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLR NVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDHSRKT IDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDITAHATAEAVTNASSESKDG KVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKIDTLQSDSTVIT GNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFNAREAFLGVIRKALEPDTSTPFPVRRAFDGLRAEI LPNDTIKSAALKAQCSDIDKHPALKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGS WRAGPAYESYLNKPGVDRVITTVDGLHMQR >Mature_670_residues MQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEIFTNSNNVAGKKAIMEF AGLFRSALNATSDSPEAKTLLMKVGAEYTTQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLS TNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTQLVDAAAAKAVKALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLR NVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDHSRKT IDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDITAHATAEAVTNASSESKDG KVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKIDTLQSDSTVIT GNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFNAREAFLGVIRKALEPDTSTPFPVRRAFDGLRAEI LPNDTIKSAALKAQCSDIDKHPALKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGS WRAGPAYESYLNKPGVDRVITTVDGLHMQR
Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates sipC activity; both are required for an efficient bacterial internalization [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) (By similarity) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the sipA/ipaA family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015138 - InterPro: IPR023224 - InterPro: IPR023225 [H]
Pfam domain/function: PF09052 SipA [H]
EC number: NA
Molecular weight: Translated: 72309; Mature: 72309
Theoretical pI: Translated: 6.75; Mature: 6.75
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEA CCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH LKEIFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTTQIIKDGLKEK HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH SAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNF CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC GCTLDPLTRSNLTQLVDAAAAKAVKALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLR CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH NVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRS HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHCCCCHH HVDNSQRHIDNSNHDHSRKTIDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQT HCCCHHHHCCCCCCCHHHHHHCCCHHHHCCCHHCCCHHCCCCCCCCCHHHHHHCCHHHHH ETAHSASTGAIDHGIAGKIDITAHATAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVD HHHCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHC GVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKIDTLQSDSTVIT CCCHHHHCCCCHHHEEECCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCEEEE GNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFNAREAFLGVIRKALE CCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHC PDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPALKAKMETLKEVITHHPQ CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC KEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVI HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHH TTVDGLHMQR HHHCCHHCCC >Mature Secondary Structure MQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEA CCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHH LKEIFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTTQIIKDGLKEK HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH SAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNF CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC GCTLDPLTRSNLTQLVDAAAAKAVKALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLR CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH NVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRS HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHCCCCHH HVDNSQRHIDNSNHDHSRKTIDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQT HCCCHHHHCCCCCCCHHHHHHCCCHHHHCCCHHCCCHHCCCCCCCCCHHHHHHCCHHHHH ETAHSASTGAIDHGIAGKIDITAHATAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVD HHHCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHC GVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKIDTLQSDSTVIT CCCHHHHCCCCHHHEEECCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCEEEE GNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFNAREAFLGVIRKALE CCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHC PDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPALKAKMETLKEVITHHPQ CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC KEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVI HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHH TTVDGLHMQR HHHCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA