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The map label for this gene is melR [H]

Identifier: 194735145

GI number: 194735145

Start: 4431785

End: 4432675

Strand: Reverse

Name: melR [H]

Synonym: SeSA_A4552

Alternate gene names: 194735145

Gene position: 4432675-4431785 (Counterclockwise)

Preceding gene: 194734207

Following gene: 194735658

Centisome position: 94.13

GC content: 51.85

Gene sequence:

>891_bases
ATGTGCAACGGCGATGAAAAGCAAACCCGTAGCCCGCTGTCGCTCTATTCCGAATATCAACGACTGGACGTTGAGCTGAG
GCCACCGCACAGAATGGCCAGCAGTCACTGGCATGGGCAAGTAGAAGTGAATGTTCCGTTTGACGGCGATGTGGAGTATT
TAATCAACAATGAAGTCGTGCAGATAAAGCAGGGACATATCACCCTGTTTTGGGCCTGTACGCCACACCAGCTTACCCGC
CCCGGCAACTGCCGCCAGATGGCGATTTTCAGTTTGCCGATGCACCTGTTTCTCTCCTGGCCGCTGGATCGCGATCTTAT
CAACCACGTCACGCACGGGATGGTGGTCAAATCACTGGCGACCCAGCAGCTTAGCACCTTTGAAGTGTTGCGCTGGCAGC
AGGAAACAAGCAGCCCGAATGAGCAAATTCGCCAGTTGGCGATCGATGAAATCGGCTTGATGCTTAAACGCTTTAGCCTT
TCCGGCTGGCAGCCCATTTTGCTCAATAAAACATCACGCACCCACAAGAATAGCGTCTCACGCCATGCGCAGTTTTACGT
AAGCCAGATGCTGGGATTTATTGCCGATAACTACGATCAGGCGCTCACCATTAACGACGTCGCGGAGCATGTCAAACTCA
ATGCTAATTACGCGATGGGAATATTCCAGCGGGTTATGCAATTGACGATGAAGCAGTACATCACGGCGATGCGCATCAAT
CACGTACGTGCCTTATTGAGCGATACTGACAAAACGATCCTCGATGTCGCTCTGACTGCCGGGTTCCGATCCAGCAGCCG
TTTTTACAGTACTTTTAGCAAATTTGTCGGCATGTCTCCGCAACAATATCGCAAGCTAAGCCAGCAACGACGCCAGACGA
TGCCCGGCTAA

Upstream 100 bases:

>100_bases
CCCGGTTTCCTCCCGGCTAAAGGGGCATAATTCTGATAATTCAGGAAATGGAGTGACGATGAGTACGCAAGCAATATCCC
TCCTCCCGCCCGACCCGCAC

Downstream 100 bases:

>100_bases
AGCCGGATACCACTATCAGCCAAAAAAATAATTCACCTGTCGATAAACGGCAGGTGAAATCGCTCGATATCAATAATTAA
CCCATTGTTTATTAAACAAT

Product: DNA-binding transcriptional regulator MelR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGHITLFWACTPHQLTR
PGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSL
SGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRIN
HVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG

Sequences:

>Translated_296_residues
MCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGHITLFWACTPHQLTR
PGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSL
SGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRIN
HVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG
>Mature_296_residues
MCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGHITLFWACTPHQLTR
PGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSL
SGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRIN
HVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=296, Percent_Identity=88.8513513513514, Blast_Score=563, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 34189; Mature: 34189

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVV
CCCCCCHHCCCHHHHHHHHHHCCCEECCCHHHHCCCCCCEEEEECCCCCCCCEEECCCEE
QIKQGHITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLA
EEECCCEEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSLSGWQPILLNKTSRTHKNSVS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
RHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRIN
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVV
CCCCCCHHCCCHHHHHHHHHHCCCEECCCHHHHCCCCCCEEEEECCCCCCCCEEECCCEE
QIKQGHITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLA
EEECCCEEEEEEECCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSLSGWQPILLNKTSRTHKNSVS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
RHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRIN
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]