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The map label for this gene is bioF [H]

Identifier: 194734987

GI number: 194734987

Start: 917338

End: 918495

Strand: Direct

Name: bioF [H]

Synonym: SeSA_A0945

Alternate gene names: 194734987

Gene position: 917338-918495 (Clockwise)

Preceding gene: 194737665

Following gene: 194737115

Centisome position: 19.48

GC content: 60.19

Gene sequence:

>1158_bases
ATGAGTTGGCAACAACGCGTCGACGATGCGCTGACGGCGCGTCGGGCGACGGATACGTTGCGCCGCCGCTATGTGGTGTC
GCAGGGCGCCGGACGCTGGCTGGTAGCTAACGGGCGACAGTATCTTAACTTCTCCAGCAATGATTACCTCGGCTTAAGTC
AACACCCGCAGATTATTCGCGCCTGGCAACAGGCAGCGATGCGTTTTGGCGTCGGCAGCGGCGGGTCGGGTCATATCAGC
GGTTATTCCGTGGCGCACCAGGCGTTAGAGGAGGAACTGGCGCAATGGTTAGGATATCCACGCGCGCTACTGTTTATCTC
TGGCTTTGCGGCGAATCAGGCGGTCATTACCGCCTTAATGAAAAAAAATGACCGGATTGTGGCCGACAGGTTGAGTCATG
CTTCCCTGCTGGAGGCCGCTAATCTGAGTCCGGCGCAGCTTCGCCGCTTTATCCATAACGATACGCAGCATCTGTCGCGT
TTACTGCAATCGCCCTGCGTGGGTCAGCAACTGGTGGTGACAGAAGGTGTATACAGCATGGACGGCGACAGCGCGCCGCT
GGCGGAAATCCAGCACATTGCCCGCAGGCATCATGCCTGGCTGTTGGTTGATGATGCGCACGGCATCGGCGTGACTGGCG
ATGAGGGGCGGGGCACCTGCTGGCAACGGGGGGTGAAGCCTGAGTTGCTGGTAGTGACTTTCGGTAAGGGGTTTGGCGTC
AGCGGCGCAGCGGTGCTCTGCTCGGAAAGCGTCGCGGATTATCTGCTGCAATTTGCCCGCCATCTGGTTTACAGCACCAG
TATGCCGCCCGCCCAGGCGCAGGCGTTAAGCGCCTCGCTGGCGGTGATCCGTAGCGATGAAGGTGGTGAACGGCGCGAAA
AACTCGCCGCTCTGGTTCAGCGCTTTCGGGCCGGCGTTAACGCGTCCCGATTTACGCTACTGAATGCCCATAGCGCCATC
CAGCCGTTAATCGTGGGCGATAACAGCCATGCATTGCGCCTGGCGGAGGCGCTACGTCAACAAGGATGCTGGGCGACGGC
GATTCGTCCGCCGACGGTGCCTGTCGGTACGGCGCGCCTGCGCTTAACGTTAACGCAGGCGCATGAAGCGTGCGATATAG
ACCGTCTGCTGGAGGTGCTGCATGGCGCAGGTGAATAA

Upstream 100 bases:

>100_bases
AGCAGACCAGGGTGCTGGCGGGCGATAACGAGCAGCAGCAACGTCTGGAGCAGACGCTGATGACGCCTGACACCGATGAT
TATTACAACGCGGCAGCCTT

Downstream 100 bases:

>100_bases
GCAGGCTATTGCGGCGGCGTTTGGCCGGGCCGCATCGCAATATGAACAACACGCCTCTTTGCAGCAACACAGCGCGGATG
CGCTACTGACGCTGTTGGCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAAMRFGVGSGGSGHIS
GYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSR
LLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQRFRAGVNASRFTLLNAHSAI
QPLIVGDNSHALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE

Sequences:

>Translated_385_residues
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAAMRFGVGSGGSGHIS
GYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSR
LLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQRFRAGVNASRFTLLNAHSAI
QPLIVGDNSHALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE
>Mature_384_residues
SWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAAMRFGVGSGGSGHISG
YSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRL
LQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGVS
GAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQRFRAGVNASRFTLLNAHSAIQ
PLIVGDNSHALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=33.4190231362468, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=35.2272727272727, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI83977442, Length=395, Percent_Identity=30.379746835443, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI83977444, Length=395, Percent_Identity=30.379746835443, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI83977440, Length=395, Percent_Identity=30.379746835443, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=30.327868852459, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4502025, Length=389, Percent_Identity=31.1053984575836, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI40316939, Length=389, Percent_Identity=31.1053984575836, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=29.7814207650273, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI5454084, Length=278, Percent_Identity=25.5395683453237, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786993, Length=384, Percent_Identity=79.9479166666667, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=34.1968911917098, Blast_Score=208, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=30.8483290488432, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=384, Percent_Identity=28.6458333333333, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=28.021978021978, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=28.021978021978, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=295, Percent_Identity=26.7796610169492, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=26.7796610169492, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320267, Length=408, Percent_Identity=26.9607843137255, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320438, Length=400, Percent_Identity=27.25, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=219, Percent_Identity=30.1369863013699, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24662918, Length=372, Percent_Identity=30.3763440860215, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137420, Length=382, Percent_Identity=30.3664921465969, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=26.7015706806283, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653280, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653276, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653278, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41954; Mature: 41823

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHH
AWQQAAMRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALM
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHH
KKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSM
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCC
DGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCC
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
RFRAGVNASRFTLLNAHSAIQPLIVGDNSHALRLAEALRQQGCWATAIRPPTVPVGTARL
HHHCCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEEE
RLTLTQAHEACDIDRLLEVLHGAGE
EEEEHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHH
AWQQAAMRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALM
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHH
KKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSM
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCC
DGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCC
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHH
RFRAGVNASRFTLLNAHSAIQPLIVGDNSHALRLAEALRQQGCWATAIRPPTVPVGTARL
HHHCCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEEE
RLTLTQAHEACDIDRLLEVLHGAGE
EEEEHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA