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The map label for this gene is gltP [H]

Identifier: 194734663

GI number: 194734663

Start: 4413587

End: 4414897

Strand: Direct

Name: gltP [H]

Synonym: SeSA_A4537

Alternate gene names: 194734663

Gene position: 4413587-4414897 (Clockwise)

Preceding gene: 194738127

Following gene: 194735683

Centisome position: 93.73

GC content: 54.16

Gene sequence:

>1311_bases
ATGAAAAATTTGAAAGTCAGCCTGGCCTGGCAAATTTTGCTGGCTATGGTGCTGGGCATTCTGTTGGGCAGCTATCTGCA
TTATCACAGTGACAGTCGTGAATGGCTGATTGCCAACCTGCTGTCGCCTGCTGGCGATATCTTTATCCACCTGATTAAAA
TGATCGTCGTGCCGATCGTGATCTCGACTCTGATTGTCGGCATCGCCGGCGTTGGCGATGCGAAACAGCTAGGCCGTATC
GGCGCCAAAACCATTCTCTATTTTGAACTGATCACCACGGTGGCGATTATCCTCGGCATTACGCTGGCGAATGTCTTTCA
GCCAGGCTCAGGCATTGATATGTCGCAACTGGCGACCGTCGATATTTCGAAATACCAGAACACCACGGCGGAAGTACAAA
GTCATGCGCATGGGCTGATGGGGACAATACTGTCGCTGGTGCCGACCAATATCATCGCATCGATGGCCAAAGGGGATATG
CTGCCAATTATCTTTTTCTCGGTCCTGTTTGGGCTGGGGTTGTCGTCCCTGCCGGCAACGCACCGCGAACCGCTGGTGAC
GGTATTTCGTTCCATCTCTGAAACCATGTTTAAAGTCACCCATATGGTGATGCGCTATGCGCCAGTAGGCGTTTTTGCGC
TGATCGCCGTCACGGTAGCGAATTTTGGTTTCGCGTCGCTGTGGCCGCTGGCGAAACTGGTGCTGCTGGTACACTTTGCC
ATTATCTTCTTTGCGCTGGTGGTGCTGGGCATCGTGGCGCGCCTGTGCGGGTTAAGTATCTGGATTCTGATTCGCATTCT
GAAAGATGAATTGATTCTGGCGTACTCGACCGCCAGCTCCGAGAGTGTGCTGCCGCGCATTATCGAGAAGATGGAAGCTT
ACGGCGCGCCAGCCTCTATCACCAGTTTCGTGGTGCCGACCGGGTACTCATTTAACCTCGACGGCTCCACGTTATACCAG
AGCATCGCCGCCATTTTTATCGCGCAGCTATACGGTATCGACCTGTCGCTGTGGCAGGAAATTGTACTGGTGCTGACGCT
GATGGTGACGTCGAAAGGGATTGCCGGCGTGCCAGGCGTTTCCTTCGTGGTGTTACTGGCGACGCTGGGCAGCGTGGGCA
TTCCGCTGGAAGGGCTGGCGTTTATCGCCGGTGTCGACCGTATCCTCGACATGGCGCGTACTGCGCTAAATGTGGTGGGG
AATGCGCTGGCGGTGCTGGTGATTGCCAAGTGGGAACACAAGTTTGACCGTAAAAAAGCGCTGGCCTATGAGCGCGACGT
ACTGGGGAAATTTGATAAGACCGCCCAATAA

Upstream 100 bases:

>100_bases
AAACTCTACAAACCAACGCAACACAAATCATACCCTTTCAGTATGTATTGCTCTCATGCTTTCGGCGGAGAGCAACGCTT
CATCGAGGAAGTCTGTTGTT

Downstream 100 bases:

>100_bases
CGGATTGCCGGATGGCGCTTTGCTTATCCGGCCTACAGAGAAAGAAAATGTAGGCCGGATAAGGCGTTCACGCCGCCATC
CGACAACCTGCTCCGGGTTG

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKNLKVSLAWQILLAMVLGILLGSYLHYHSDSREWLIANLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVGDAKQLGRI
GAKTILYFELITTVAIILGITLANVFQPGSGIDMSQLATVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIIASMAKGDM
LPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFASLWPLAKLVLLVHFA
IIFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIDLSLWQEIVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWEHKFDRKKALAYERDVLGKFDKTAQ

Sequences:

>Translated_436_residues
MKNLKVSLAWQILLAMVLGILLGSYLHYHSDSREWLIANLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVGDAKQLGRI
GAKTILYFELITTVAIILGITLANVFQPGSGIDMSQLATVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIIASMAKGDM
LPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFASLWPLAKLVLLVHFA
IIFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIDLSLWQEIVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWEHKFDRKKALAYERDVLGKFDKTAQ
>Mature_436_residues
MKNLKVSLAWQILLAMVLGILLGSYLHYHSDSREWLIANLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVGDAKQLGRI
GAKTILYFELITTVAIILGITLANVFQPGSGIDMSQLATVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIIASMAKGDM
LPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALIAVTVANFGFASLWPLAKLVLLVHFA
IIFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIDLSLWQEIVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWEHKFDRKKALAYERDVLGKFDKTAQ

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=466, Percent_Identity=26.6094420600858, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI169790839, Length=454, Percent_Identity=26.8722466960352, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI194239697, Length=467, Percent_Identity=26.338329764454, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI66773030, Length=470, Percent_Identity=28.0851063829787, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI21314632, Length=421, Percent_Identity=25.6532066508314, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4827012, Length=425, Percent_Identity=29.1764705882353, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI5032093, Length=409, Percent_Identity=27.1393643031785, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=28.7769784172662, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI223468564, Length=278, Percent_Identity=28.7769784172662, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI262359914, Length=395, Percent_Identity=25.3164556962025, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI301601644, Length=184, Percent_Identity=30.9782608695652, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790514, Length=436, Percent_Identity=93.8073394495413, Blast_Score=826, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=40.3381642512077, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788024, Length=428, Percent_Identity=25.2336448598131, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=388, Percent_Identity=22.1649484536082, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71983106, Length=459, Percent_Identity=27.8867102396514, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=459, Percent_Identity=27.8867102396514, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=25.8373205741627, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=455, Percent_Identity=27.2527472527473, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=28.9760348583878, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=447, Percent_Identity=25.9507829977629, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=422, Percent_Identity=25.5924170616114, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24583025, Length=469, Percent_Identity=26.6524520255864, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17137668, Length=469, Percent_Identity=26.6524520255864, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24583023, Length=469, Percent_Identity=26.6524520255864, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI281360483, Length=457, Percent_Identity=27.1334792122538, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137666, Length=457, Percent_Identity=27.1334792122538, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281360481, Length=457, Percent_Identity=27.1334792122538, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47024; Mature: 47024

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]