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The map label for this gene is lldD [H]

Identifier: 194734323

GI number: 194734323

Start: 3767763

End: 3768953

Strand: Direct

Name: lldD [H]

Synonym: SeSA_A3895

Alternate gene names: 194734323

Gene position: 3767763-3768953 (Clockwise)

Preceding gene: 194735151

Following gene: 194734332

Centisome position: 80.01

GC content: 59.61

Gene sequence:

>1191_bases
ATGATTATTTCAGCAGCCAGCGATTATCGCGCCGCAGCTCAGCGCACGTTGCCTCCTTTCCTCTTCCACTACATCGACGG
CGGCGCGTATGCGGAATATACCCTGCGCCGAAATGTGGAAGACCTGTCGCAAGTCGCTCTGCGCCAGCGCGTGCTGAAAA
ATATGTCCGATTTAAGCCTGGAAACGACCCTGTTTAACGAAACGTTGTCGATGCCGGTGGCATTAGCGCCGGTAGGCCTG
TGCGGCATGTACGCCCGTCGCGGCGAAGTACAGGCCGCCGCCGCCGCAGACGCAAAGGGCATTCCGTTCACCCTTTCCAC
CGTCTCCGTCTGTCCGATTGAAGAAGTCGCCCCCACGCTTAAACGCCCCATGTGGTTTCAGCTCTACGTATTACGCGATC
GTGGTTTTATGCGCAACGCGCTTGAACGAGCAAAAGCGGCGGGCTGCTCCACGCTGGTCTTTACCGTGGATATGCCGACG
CCGGGCGCGCGCTACCGTGACGCCCACTCCGGGATGAGCGGCCCAAACGCGGCCATGCGCCGTTACTGGCAGGCGGTGAT
GCACCCTAAATGGGCGTGGGATGTCGGCCTGAACGGTCGCCCGCATGATTTAGGCAATATTTCCGCCTATCTGGGTAAAC
CGACCGGCCTTGAGGACTATATCGGCTGGCTGGCAAATAACTTCGATCCGTCCATCTCCTGGAAGGATCTGGAGTGGATA
CGCGAATTCTGGGACGGCCCAATGGTGATCAAAGGGATCCTCGATCCAGAAGATGCCCGCGATGCGGTACGTTTCGGCGC
TGACGGTATTGTGGTGTCGAATCACGGCGGCCGCCAGCTCGATGGCGTGCTCTCTTCCGCCCGCGCCCTGCCCGCCATTG
CCGATGCGGTGAAAGGTGATATCGCCATTCTGGCGGATAGCGGGATTCGTAACGGGCTGGATGTCGTGCGTATGATTGCG
TTGGGGGCCGATACCGTACTGCTGGGTCGGGCCTATCTCTACGCGCTGGCGACGGCAGGAAAAGCGGGTGTCGCCAACCT
GCTGGACCTGATCGAGAAAGAGATGAAAGTCGCCATGACCCTGACCGGCGCGAAATCCATTAGTGAAATCAGTGGCGATT
CACTGGTGCAGGAACTGGGGAGAAGTTTGCCCGCCGCGCTGGCGCCAATGAGCAAAGGCGATGCCGCCTGA

Upstream 100 bases:

>100_bases
TCCACACCACGATTAAACGATTTGATGAAGACCAGGCCCGCCAGGCGCGTATTACCCGCCTGCCCGGCGACCATAATGAG
ATGACCAGGGAGAATAAATC

Downstream 100 bases:

>100_bases
ACGCCTGGCGCGTGAGAGCCCGGTAAATTTCTGCTATTCTGCCCCCCGCATTTAAGGGGGCATCATGCTTAACATCGTAC
TCTTCGAACCAGAAATCCCG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGRSLPAALAPMSKGDAA

Sequences:

>Translated_396_residues
MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGRSLPAALAPMSKGDAA
>Mature_396_residues
MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGRSLPAALAPMSKGDAA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=366, Percent_Identity=33.6065573770492, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI54234014, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI7705393, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790033, Length=396, Percent_Identity=93.6868686868687, Blast_Score=761, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=34.7708894878706, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.7464788732394, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=28.2722513089005, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI78707188, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281363140, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI78707190, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42743; Mature: 42743

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LTGAKSISEISGDSLVQELGRSLPAALAPMSKGDAA
ECCCHHHHHHCHHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure
MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LTGAKSISEISGDSLVQELGRSLPAALAPMSKGDAA
ECCCHHHHHHCHHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA