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The map label for this gene is idnD [H]

Identifier: 194734309

GI number: 194734309

Start: 4604015

End: 4605046

Strand: Reverse

Name: idnD [H]

Synonym: SeSA_A4739

Alternate gene names: 194734309

Gene position: 4605046-4604015 (Counterclockwise)

Preceding gene: 194735349

Following gene: 194737794

Centisome position: 97.79

GC content: 49.81

Gene sequence:

>1032_bases
ATGGAAGTAAAAACTCAATCCTGCGTTGTTGCGGGTAAGCGTGCTGTTGCCGTTACGGAACAAAATATTGAATGGAATAA
TAAAGGAACACTCGTACAAATTACCCGAGGCGGCATTTGTGGGTCTGACTTACATTATTATCAGGAAGGCAAAGTCGGCA
ATTTTACAGTAAAAGCGCCAATGATTTTAGGTCATGAAGTGATTGGCAAAATCGTTCATAGCGACTCAGATTTATTACGT
GAAGGACAACCGGTAGCGATTAATCCATCGAAGCCTTGCGGTCATTGCAAATACTGTCTGCAGCATGAAGAAAACCACTG
TACTGAAATGCGTTTCTTTGGCAGCGCCATGTATTTTCCGCATGTCGATGGCGGTTTTACCCGATTTAAATCTGTCGATA
CCGTTCAGTGCATTCCCTGGCCGGAACAGGCAGACGAAAAAGCCATGGCCTTTGCCGAACCGCTGGCGGTTGCCATTCAT
GCGGCTCATGAGGCGGGCGATCTGCAAGGCAAACGCGTCTTTATCTCCGGCGTTGGCCCTATCGGCTGCCTGATTGTTAG
CGCGGTAAAAACGCTGGGCGCAGCGGAAGTGGTATGTGCTGATATCAGTACCCGTTCTCTCTCGCTGGCCCGGCAGATGG
GCGCGGATACGCTGGTAAACCCACAGCATGACTCTCTTGATGGCTGGAAAGCAGAAAAAGGGTATTTCGATATCAGTTTT
GAAGTCTCCGGGCATCCTTCCTCAATCTCAACGTGTCTGGAAGTCACACGGGCAAAAGGCGTGATGGTGCAGGTTGGCAT
GGGCGGCGCAGTCCCCAACTTCCCGATGATGATGGTAATAAGCAAAGAGATCTCCCTGAAAGGCTCTTTCCGCTTTACTA
CCGAATTTAATACTGCGGTTTCCTGGCTTGCCAACCGCGTTATCAATCCGCTGCCGTTACTGAGCGCGGAATATCCATTT
ACCGACCTGGAAGCGGCGCTGATCTTTGCCGGAGACAAAACACAGGCGGCAAAAGTTCAGCTCGTTTTCTGA

Upstream 100 bases:

>100_bases
TTGTAGTGTAACAATTTTCCAGCGTGACATAAGTCACAAATAATGACAAATAAAACCGCTTAAATGCGTTCAGGGTAACT
ACCTGACCAGTGAGGAATTT

Downstream 100 bases:

>100_bases
GAAAGTAAAATAAGGGACACTATCATGAACGATCTTTTTTCACTGGCAGGTAAAAATATCCTTATCACCGGAGCCGCTCA
GGGAATTGGTTATTTGCTGG

Product: L-idonate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSKPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKSVDTVQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRVFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDGWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF

Sequences:

>Translated_343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSKPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKSVDTVQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRVFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDGWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF
>Mature_343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSKPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKSVDTVQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRVFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDGWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=306, Percent_Identity=33.6601307189542, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1790718, Length=343, Percent_Identity=83.3819241982507, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1788073, Length=307, Percent_Identity=28.3387622149837, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787863, Length=344, Percent_Identity=27.0348837209302, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790045, Length=312, Percent_Identity=26.9230769230769, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=28.5285285285285, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI226510992, Length=300, Percent_Identity=30, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1786825, Length=217, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=24.3243243243243, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082125, Length=272, Percent_Identity=27.2058823529412, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=25.1497005988024, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=321, Percent_Identity=35.202492211838, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17562878, Length=324, Percent_Identity=33.641975308642, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322619, Length=304, Percent_Identity=32.5657894736842, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319955, Length=308, Percent_Identity=32.4675324675325, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323099, Length=335, Percent_Identity=30.4477611940298, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319258, Length=309, Percent_Identity=26.537216828479, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=295, Percent_Identity=24.7457627118644, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=271, Percent_Identity=26.1992619926199, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=316, Percent_Identity=31.3291139240506, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17137530, Length=312, Percent_Identity=30.1282051282051, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37139; Mature: 37139

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAP
CCCCCCHHEEECCEEEEEEECCCEECCCCCEEEEECCCCCCCCCEEEECCCCCCEEEECC
MILGHEVIGKIVHSDSDLLREGQPVAINPSKPCGHCKYCLQHEENHCTEMRFFGSAMYFP
HHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRFKSVDTVQCIPWPEQADEKAMAFAEPLAVAIHAAHEAGDLQGKRVFISGVGP
CCCCCHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEHHCCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDGWKAEKGYFDISF
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEE
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAV
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECEEECCCEEEEEEHHHHH
SWLANRVINPLPLLSAEYPFTDLEAALIFAGDKTQAAKVQLVF
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAP
CCCCCCHHEEECCEEEEEEECCCEECCCCCEEEEECCCCCCCCCEEEECCCCCCEEEECC
MILGHEVIGKIVHSDSDLLREGQPVAINPSKPCGHCKYCLQHEENHCTEMRFFGSAMYFP
HHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRFKSVDTVQCIPWPEQADEKAMAFAEPLAVAIHAAHEAGDLQGKRVFISGVGP
CCCCCHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHEEEEEHHCCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDGWKAEKGYFDISF
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEE
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAV
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECEEECCCEEEEEEHHHHH
SWLANRVINPLPLLSAEYPFTDLEAALIFAGDKTQAAKVQLVF
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]