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The map label for this gene is rnc [H]

Identifier: 194733998

GI number: 194733998

Start: 2725933

End: 2726670

Strand: Reverse

Name: rnc [H]

Synonym: SeSA_A2824

Alternate gene names: 194733998

Gene position: 2726670-2725933 (Counterclockwise)

Preceding gene: 194737191

Following gene: 194737392

Centisome position: 57.9

GC content: 52.44

Gene sequence:

>738_bases
GTGTATCAGGTCTGTTTCGTGTGCTGGATTGTTGACGCATTCATTTATTGGTATCGCATGAACCCCATCGTAATTAATCG
GCTTCAACGGAAGCTGGGCTACACTTTTAATCATCAGGAGCTGTTGCAGCAGGCATTAACTCACCGCAGCGCCAGCAGTA
AACATAACGAACGCCTGGAATTTTTAGGCGATTCAATCCTGAGCTTCGTTATCGCTAACGCGCTTTATCACCGTTTCCCA
CGGGTGGATGAGGGAGATATGAGCCGTATGCGCGCCACGTTGGTACGTGGTAATACGCTGGCGGAATTAGCCCGTGAATT
TGATTTAGGCGAGTGCCTGCGTTTAGGGCCGGGCGAATTAAAAAGCGGCGGATTCCGTCGAGAGTCCATTCTGGCGGACA
CCGTGGAAGCGTTAATCGGCGGAGTATTTCTCGATAGCAATATCCAGACCGTCGAGCAGTTAATCCTTAACTGGTATAAA
ACTCGTCTGGATGAGATAAGTCCGGGCGATAAACAAAAAGATCCGAAAACGCGCTTGCAGGAGTATTTGCAGGGTCGCCA
TCTGCCGCTGCCATCTTACCTGGTTGTGCAGGTGCGCGGCGAGGCGCACGATCAGGAATTTACTATCCACTGCCAGGTCA
GCGGCCTGAGCGAACCGGTGGTTGGCACGGGTTCCAGCCGTCGTAAGGCGGAGCAGGCTGCCGCCGAACAGGCGCTGAAA
AAACTGGAGTTGGAATGA

Upstream 100 bases:

>100_bases
GAAGTTTTAGGTTGGCGCCGTTTGGTCGCCACGGCACACGAAACAGCGTTGGTTATAGACAACCTTCTTTCCACTGCAGC
GATGCGGCAGGACAGATGAC

Downstream 100 bases:

>100_bases
GCACTGACAAAACTTACTGCGGATTTATTGCCATCGTCGGGCGTCCGAACGTTGGCAAATCCACCTTGCTGAACAAACTG
CTTGGGCAGAAGATTTCGAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MYQVCFVCWIVDAFIYWYRMNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFP
RVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYK
TRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALK
KLELE

Sequences:

>Translated_245_residues
MYQVCFVCWIVDAFIYWYRMNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFP
RVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYK
TRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALK
KLELE
>Mature_245_residues
MYQVCFVCWIVDAFIYWYRMNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFP
RVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYK
TRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALK
KLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=97.3451327433628, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=28.921568627451, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=28.3842794759825, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27993; Mature: 27993

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVCFVCWIVDAFIYWYRMNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLE
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
FLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGEL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCC
KSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRLQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
EYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALK
HHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
KLELE
HHCCC
>Mature Secondary Structure
MYQVCFVCWIVDAFIYWYRMNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLE
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
FLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFDLGECLRLGPGEL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHCCCCCC
KSGGFRRESILADTVEALIGGVFLDSNIQTVEQLILNWYKTRLDEISPGDKQKDPKTRLQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
EYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALK
HHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
KLELE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA